Coronary atherosclerotic heart disease (CHD) is one of the common diseases of the cardiovascular system, and it is also a common disease that seriously endangers human health. Patients with CHD are usually combined with anxiety and depression. In recent years, a large number of studies have shown that the incidence of CHD combined with anxiety and depression is gradually increasing, which seriously affects the prognosis of the disease and the quality of life of patients. This article reviews the epidemiology, pathogenesis and treatment of traditional Chinese and Western medicine, and provides reference for clinical practice.

Zhenzhen Li, Dongmin Liu, Youquan Lu. Research progress of CHD combined with anxiety and depression in Chinese and Western medicine. Academic Journal of Medicine & Health Sciences (2023) Vol. 4, Issue 4: 48-54. https://doi.org/10.25236/AJMHS.2023.040408.

[1] Ma Liyuan, Wang Zengwu, Fan Jing, etc. Interpretation of the key points of China Cardiovascular Health and Disease Report 2021 [J].China General Practice, 2022, 25 (27) : 3331-3346.

[2] Hu Dayi. Integrated Management of Cardiovascular Diseases and Psychopsychological Disorders —Exploration of the Psycho-cardiology" Model [J]. Chinese Clinician, 2006 (05): 2-3.

[3] Stewart JC, Hawkins MA, Khambaty T, et al. Depression and Anxiety Screens as Predictors of 8-Year Incidence of Myocardial Infarction and Stroke in Primary Care Patients. Psychosom Med. 2016 Jun; 78(5):593-601.

[4] Gu G, Zhou Y, Zhang Y. et al. Increased prevalence of anxiety and depression symptoms in patients with coronary artery disease before and after percutaneous coronary intervention treatment. BMC Psychiatry. 2016 Jul 22; 16: 259.

[5] Zhu Jifang, Li Yuanqiong, Chen Chaorong, et al. Investigation of anxiety and depression status and influencing factors in patients with coronary heart disease. Laser Journal, 2014, 35 (9): 127-129.

[6] Li Xiaojing, Zhang Lan, Li Bin. Study on the diagnosis and treatment of depression and anxiety disorders in outpatients of Chengdu General Hospital [J]. Huaxi Medicine, 2011,26 (02) : 192-194.

[7] Taleb S. Inflammation in atherosclerosis. Arch Cardiovasc Dis. 2016 Dec; 109 (12): 708-715.

[8] Tayefi M, Shafiee M, Kazemi-Bajestani SMR. Depression and anxiety both associate with serum level of hs-CRP: A gender-stratified analysis in a population-based study. Psychoneuroendocrinology. 2017 Jul; 81: 63-69.

[9] Zhang Xiaolei, Zhao Yongfeng, Ren Yanchun, et al. The relationship between anxiety and depression and inflammatory response and vascular endothelial function in patients with coronary heart disease [J].Chinese Journal of Evidence-based Cardiovascular Medicine, 2018, 10 (02): 199-202.

[10] Yang Yibo, Song Chunli, Shi Yongfeng, et al. Research progress on the negative mechanism of mental and psychological diseases on cardiovascular [J]. China Laboratory Diagnostics, 2016, 20 (08): 1408-1410.

[11] Goldston K, Baillie AJ. Depression and coronary heart disease: a review of the epidemiological evidence, pharmacological mechanisms and management approaches. Clin Psychol Rev. 2008 Feb; 28 (2): 288-306.

[12] Shi Jinyu, Wang Chao, Huang Lexi, et al. Research progress in the treatment of coronary heart disease with anxiety and depression [J].World Chinese Medicine, 2022,17 (14) : 2087-2091.

[13] Huang Yu. Advances in research on the association between depression and coronary heart disease [J]. Electronic Journal of Integrated Traditional Chinese and Western Medicine Cardiovascular Disease, 2018, 6 (10): 22-23.

[14] Zhuang X, Xu H, Fang Z, Xu C, et al. Platelet serotonin and serotonin transporter as peripheral surrogates in depression and anxiety patients. Eur J Pharmacol. 2018 Sep 5; 834:213-220.

[15] Fan Xinbiao, Fu Huanjie, Qi Zhongwen, et al. 'Blood-Vein-Heart-Spirit' integrated view of syndrome differentiation and treatment of coronary heart disease with anxiety and depression [J].Chinese Journal of Traditional Chinese Medicine, 2022, 37 (10) : 5798-5801.

[16] Su Xiang, Zhao Mingfen. Analysis of distribution characteristics and influencing factors of TCM syndromes in patients with coronary heart disease complicated with anxiety and depression [J].Liaoning Journal of Traditional Chinese Medicine, 2021,48 (05) : 14-18.

[17] Chen Xiaohu, Zhu Xianhui, Chen Jiandong, et al. Expert Consensus on the Diagnosis and Treatment of Double Heart Diseases with Integrated Traditional Chinese and Western Medicine [J]. China General Practice, 2017,20 (14) : 1659-1662.

[18] Chao Tiantian, Zhang Dawu, Sun Jinghui, et al. Modern literature research on the distribution characteristics of TCM syndromes and syndrome elements in coronary heart disease with anxiety or depression [J].World Science and Technology-Modernization of Traditional Chinese Medicine, 2020,22 (05) : 1405-1411.

[19] Liu Yong. Clinical evaluation of influencing factors, syndrome characteristics and intervention of promoting blood circulation and removing blood stasis in coronary heart disease with depression [D]. Beijing: Beijing University of Chinese Medicine, 2021.

[20] Sheng Ling. Study on the difference between TCM syndromes of coronary heart disease with depression and anxiety and 5-HT, IL6 and H-CRP [D]. Urumqi: Xinjiang Medical University, 2021.

[21] Wang Zehua. Study on the distribution of TCM syndromes and related influencing factors of coronary heart disease complicated with generalized anxiety disorder [D]. Tianjin: Tianjin University of Traditional Chinese Medicine, 2021.

[22] Gong Shan, Wang Longfei, Yu Guolong. Benefit and risk assessment of antidepressants in patients with cardiovascular disease [J].Pharmaceutical Review, 2018, 37 (10): 1194-1198.

[23] Gao Yang, Zhou Hongdan, Yang Yutong, et al. Research progress on coronary heart disease with anxiety and depression [J]. China Primary Health Care, 2019, 33 (12): 74-77.

[24] Almog R, Carasso S, Lavi I, et al. The risk for a first acute coronary syndrome in patients treated with different types of antidepressants: A population based nested case-control study. Int J Cardiol. 2018 Sep 15; 267:28-34. 

[25] Andrade C, Kumar CB, Surya S. Cardiovascular mechanisms of SSRI drugs and their benefits and risks in ischemic heart disease and heart failure. 28 (3): 145-55.

[26] Hamer M, Batty GD, Seldenrijk A, et al. Antidepressant medication use and future risk of cardiovascular disease: the Scottish Health Survey. Eur Heart J. 2011 Feb; 32 (4): 437-42.

[27] Thom RP, Alexander JL, Baron D, et al. Selective Serotonin Reuptake Inhibitors: How Long Is Long Enough? J Psychiatr Pract. 2021 Sep 16; 27 (5): 361-371.

[28] Post-Myocardial Infarction Depression Clinical Practice Guideline Panel. AAFP guideline for the detection and management of post-myocardial infarction depression. Ann Fam Med. 2009 Jan-Feb; 7(1):71-9.

[29] Liu Chunping, Cui Zhenshuang. The clinical diagnosis and treatment strategy of coronary atherosclerotic heart disease with anxiety and depression [J]. Chinese Journal of Clinicians, 2022, 50 (04): 385-387.

[30] Li Hongguo, Ge Jinhua. Observation on the effect of Deanxit in the treatment of senile coronary heart disease with anxiety and depression [J].Integrated Chinese and Western Medicine Cardiovascular Electronic Journal, 2015, 3 (33) : 55-56.

[31] Yan Chengying, Wang Xiaoyong, Wen Yuanshan, et al. The characteristics of anxiety and depression in patients with coronary heart disease and the value of drug intervention [J].Chinese Journal of Evidence-based Cardiovascular Medicine, 2018,10 (11) : 1351-1353.

[32] Wang C, Hou J, Yan S, et al. Chinese herbal medicine therapy for coronary heart disease complicated with anxiety: a systematic review of randomized controlled trials. J Tradit Chin Med. 2020 Feb; 40 (1): 1-16.

[33] Yang Liqiang, Ji Fanxia, Chen Lin, et al. Clinical observation of Jiawei Chaihu Shugan Powder in the treatment of coronary heart disease complicated with depression [J].Journal of Guangxi University of Traditional Chinese Medicine, 2020,23 (01) : 1-4.

[34] Zhang Yuanwen, Yuan Tianhui, Pan Jianlue, et al. Meta-analysis of Chaihu Jia Longgu Muli Decoction in the treatment of coronary heart disease with anxiety and depression [J].New Chinese medicine and clinical pharmacology, 2022,33 (10) : 1435-1444.

[35] Li Chengfang. Clinical Observation on 40 Cases of Angina Pectoris of Coronary Heart Disease Complicated with Anxiety and Depression Treated and Western Medicine [J].Chinese Folk Medicine, 2018,27 (12) : 118-120.

[36] Gao Denan. Clinical observation of Xuefu Zhuyu Decoction in the treatment of coronary heart disease with mild depression [J].Integrated Chinese and Western Medicine Cardiovascular Disease Electronic Journal, 2019, 7 (26): 146 + 158.

[37] Zhan Ping, Wu Lijun, Wang Xinghui, et al. Clinical efficacy of Xinkeshu in the treatment of anxiety and depression after PCI for coronary heart disease [J].Integrated Chinese and Western Medicine Journal of Cardio-cerebrovascular Disease, 2017,15 (23) : 2960-2962.

[38] Hou Yingwei. Effect of Xinkeshu Tablets on anxiety and quality of life in patients with coronary heart disease after percutaneous coronary intervention [J]. China Contemporary Medicine, 2020, 27 (22): 66-68 + 72.

[39] Li Che, Jiang Jun. Effect of Yixinshu capsule on quality of life, anxiety and depression in patients after PCI [J].Journal of Nanjing University of Chinese Medicine, 2017,33 (03) : 242-244.

[40] Huang Xiaocheng, Jiang Ruilai, Li Li, etc. Clinical Study of Guanxinning Tablets in the Treatment of Coronary Heart Disease Complicated with Depression [J].New Chinese Medicine, 2020,52 (18) : 72-75.

[41] Zhang Yaoxiao, Hui Ruting, Tang Yu, etc. Effect of acupuncture intervention on insomnia with depression [J]. Chinese Journal of Traditional Chinese Medicine, 2020, 35 (08): 4271-4274.

[42] Ma Ruijie, Chen Weiji, Xu Xia, et al. A randomized controlled study on the treatment of insomnia with anxiety by harmonizing stomach acupuncture [J]. Chinese Journal of Traditional Chinese Medicine, 2019, 34 (02): 834-837.

[43] Liu Lili. Effect of acupuncture on electrocardiogram of coronary heart disease with depression [J].Journal of Clinical Acupuncture, 2009, 25 (11): 23-24.

[44] Wu Yonghui, Chen Ouying, Luo Yaoyue, et al. Application of Tai Chi and Baduanjin in improving anxiety and depression in patients with coronary heart disease [J].Nursing research, 2016,30 (32) : 4050-4052.

[45] Liu J, Yu P, Lv W. Wang X. The 24-Form Tai Chi Improves Anxiety and Depression and Upregulates miR-17-92 in Coronary Heart Disease Patients after Percutaneous Coronary Intervention. Front Physiol. 2020 Mar 11; 11: 149.

[46] Han X, Liu X, Zhong F. Comparison of efficacy and safety of complementary and alternative therapies for coronary heart disease complicated with anxiety or depression disorder: A protocol for Bayesian network meta-analysis. Medicine (Baltimore). 2021 Mar 26; 100 (12): e25084.