Welcome to Francis Academic Press

International Journal of Frontiers in Medicine, 2023, 5(4); doi: 10.25236/IJFM.2023.050401.

New Advances in the Pathogenesis and Treatment of Dry Eye after Diabetic Cataract Surgery

Author(s)

Wenjing Cai1,2, Zhiqin Wu1

Corresponding Author:
Zhiqin Wu
Affiliation(s)

1Department of Ophthalmology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, Hubei, China

2Medical School, Yangtze University, Jingzhou, Hubei, China

Abstract

Diabetic cataract is a common complication in diabetic patients. As the diabetic population continues to expand, the number of patients with diabetic cataract is also increasing. Currently, the primary treatment is cataract ultrasound emulsification hand combined with IOL implantation. However, it has been clinically found that these patients have a high incidence of postoperative dry eye, and in severe cases, corneal epithelial defects and ulcers may also occur, which affects the patient's postoperative comfort and visual function. In order to further improve the understanding of postoperative dry eye in diabetic cataract and enhance the postoperative situation, this paper reviews and analyzes the pathogenesis and new advances in the treatment of postoperative dry eye in diabetic cataract.

Keywords

Diabetic cataract, Dry eye syndrome, Phacoemulsification

Cite This Paper

Wenjing Cai, Zhiqin Wu. New Advances in the Pathogenesis and Treatment of Dry Eye after Diabetic Cataract Surgery. International Journal of Frontiers in Medicine (2023), Vol. 5, Issue 4: 1-5. https://doi.org/10.25236/IJFM.2023.050401.

References

[1] Yusufu M, Liu X, Zheng T, et al. Hydroxypropyl methylcellulose 2% for dry eye prevention during phacoemulsification in senile and diabetic patients. Int Ophthalmol. 2018; 38(3):1261-1273. 

[2] Sahu PK, Das GK, Malik A. Dry eye following phacoemulsification surgery and its relation to associated intraoperative risk factors. Middle East Afr J Ophthalmol. 2015; 22(4):472–7.

[3] Jiang D, Xiao X, Fu T, et al. Transient Tear Film Dysfunction after Cataract Surgery in Diabetic Patients. PLoS One. 2016; 11(1):e0146752. 

[4] Xie C, Fang F, Fang Y. Clinical analysis on T2DM and xerophthalmia after cataract surger[J]. New Advances in Ophthalmology, 2017: 773-775. 

[5] Sandra Johanna GP, Antonio LA, Andrés GS. Correlation between type 2 diabetes, dry eye and Meibomian glands dysfunction. j Optom. 2019; 12(4):256-262. 

[6] Darenskaya MA, Kolesnikova LI, Kolesnikov SI. Oxidative Stress: Pathogenetic Role in Diabetes Mellitus and Its Complications and Therapeutic Approaches to Correction. Bull Exp Biol Med. 2021 May; 171(2):179-189. 

[7] Zou X, Zhang P, Xu Y, et al. Quantitative Proteomics and Weighted Correlation Network Analysis of Tear Samples in Type 2 Diabetes Patients Complicated Proteomics Clin Appl. 2020 ; 14(4):e1900083. doi: 10.1002/prca.201900083.

[8] Gao YJ, Zhang SH, Hong Y, et al. Efficacy of Manual Small Incision Cataract Extraction in Treatment of Cataract Patients and Its Effect on Tear Film Function and Optic Nerve Fiber Layer[J]. Journal of Liberation Army Medicine, 2019, 31(10):76-79. 

[9] Jin Y, Wang W, Chen W, et al. Corneal confocal microscopy: A useful tool for diagnosis of small fiber neuropathy in type 2 diabetes. j Diabetes Investig. 2021; 12(12):2183-2189. 

[10] Yu FX, Lee PSY, Yang L, et al. The impact of sensory neuropathy and inflammation on epithelial wound healing in diabetic corneas. prog Retin Eye Res. 2022; 89:101039. 

[11] DeMill DL, Hussain M, Pop-Busui R, et al. Ocular surface disease in patients with diabetic peripheral neuropathy. br J Ophthalmol. 2016; 100(7):924- 928. 

[12] Ganesh S, Brar S, Arra RR. Refractive lenticule extraction small incision lenticule extraction: a new refractive surgery paradigm. Indian J Ophthalmol. 2018;66(1):10-19.

[13] Miric DJ, Kisic BB, Zoric LD, et al. Xanthine oxidase and lens oxidative stress markers in diabetic and senile cataract patients. j Diabetes Complications. 2013; 27(2):171-6. doi: 10. 1016/ j. jdiacomp. 2012. 09.005. epub 2012 8.

[14] Magno MS, Utheim TP, Snieder H, et al. The relationship between dry eye and sleep quality. Ocul Surf. 2021; 20:13-19.

[15] Miao Xiaoqing, Huang Zufeng, Yang Xiaoxi. Clinical observation on the changes of xerophthalmia related indexes in diabetic patients after phacoemulsification[J]. Chinese Journal of Ophthalmology (electronic version), 2015(6):297-302. 

[16] Wang Y, Yang YN. Advances in Diabetic Keratopathy[J]. Chinese Journal of Optometry and Visual Science, 2020, 22(12):951-955. 

[17] Negre-Salvayre A, Salvayre R, Augé N, et al. Hyperglycemia and glycation in diabetic complications. Antioxid Redox Signal. 2009; 11(12):3071-109. 

[18] Li JM, Lu R, Zhang Y, et al. IL-36α/IL-36RA/IL-38 signaling mediates inflammation and barrier disruption in human corneal epithelial cells under Ocul Surf. 2021 Oct; 22: 163-171. 

[19] Zhang Y, Yang M, Zhao SX, et al. Hyperosmolarity disrupts tight junction via TNF-α/MMP pathway in primary human corneal epithelial cells. int J Ophthalmol. 2022 May 18; 15(5):683-689. 

[20] Liu R, Ma B, Gao Y, et al. Tear Inflammatory Cytokines Analysis and Clinical Correlations in Diabetes and Nondiabetes With Dry Eye. am J Ophthalmol. 2019 Apr; 200:10-15. 

[21] Perez VL, Stern ME, Pflugfelder SC, et al. Inflammatory basis for dry eye disease flares [J]. Exp Eye Res, 2020, 201: 108294.

[22] Zhang K, Zhang S, Yu J, et al. Changes of the tear film lipid layer thickness after cataract surgery in patients with diabetes mellitus. acta Ophthalmol. 2021; 99(2):e202-e208. 

[23] Di Zazzo A, Coassin M, Micera A, et al. Ocular surface diabetic disease: A neurogenic condition? Ocul Surf. 2021; 19:218-223. 

[24] Fujishima H, Tsubota K. Improvement of corneal fluorescein staining in post cataract surgery of diabetic patients by an oral aldose reductase inhibitor, ONO-2235. Br J Ophthalmol. 2002; 86(8):860-3. 

[25] Zagon IS, Sassani JW, Purushothaman I, et al. Blockade of OGFr delays the onset and reduces the severity of diabetic ocular surface complications. Exp Biol Med (Maywood). 2021; 246(5):629-636. 

[26] Starr CE, Gupta PK, Farid M, et al. An algorithm for the preoperative diagnosis and treatment of ocular surface disorders. J Cataract Refract Surg. 2019; 45(5):669-684. 

[27] Jones L, Downie LE, Korb D, et al. TFOS DEWS II Management and Therapy Report. Ocul Surf. 2017; 15(3):575-628. 

[28] Suwal A, Hao JL, Zhou DD, et al. Use of Intense Pulsed Light to Mitigate Meibomian Gland Dysfunction for Dry Eye Disease. int J Med Sci. 2020 Jun 1;17(10):1385-1392.

[29] Sandra Johanna GP, Antonio LA, Andrés GS. Correlation between type 2 diabetes, dry eye, and Meibomian glands dysfunction. j Optom. 2019; 12(4):256-262. 

[30] Yokoi N, Georgiev GA. Tear Film-Oriented Diagnosis and Tear Film-Oriented Therapy for Dry Eye Based on Tear Film Dynamics. Invest Ophthalmol Vis Sci. 2018; 59(14): DES13-DES22. 

[31] Quiroz-Mercado H, Hernandez-Quintela E, Chiu KH, et al. A phase II randomized trial to evaluate the long-term (12-week) efficacy and safety of OC-01 Ocul Surf. 2022 Apr;24:15-21. 

[32] Dua HS, Said DG, Messmer EM, et al. Neurotrophic keratopathy. Prog Retin Eye Res. 2018; 66:107-131. 

[33] Wu X, Ma Y, Chen X, et al. Efficacy of bandage contact lens for the management of dry eye disease after cataract surgery. Int Ophthalmol. 2021; 41(4):1403 -Epub 2021 28. 

[34] Alvarez-Rivera F, Concheiro A, Alvarez-Lorenzo C. Epalrestat-loaded silicone hydrogels as contact lenses to address diabetic-eye complications. Eur J Pharm Biopharm. 2018; 122:126-136. 

[35] Mead OG, Tighe S, Tseng SCG. Epalrestat-loaded silicone hydrogels as contact lenses to address diabetic-eye complications. eur J Pharm Biopharm. 2018; 122:126-136.  

[36] Su JZ, Zheng B, Wang Z, et al. Submandibular Gland Transplantation vs Minor Salivary Glands Transplantation for Treatment of Dry Eye: A Retrospective Cohort Study. Am J Ophthalmol. 2022; 241:238-247.