Postoperative residual pain after osteoporosis vertebral compression fracture (OVCF) is one of the most common complications in postoperative patients, which decrease surgical satisfaction and seriously affect patients' quality of life. In contrast, Chinese medicine therapy is an important therapeutic role in postoperative residual pain after OVCF. In this paper, we summarize and analyze the mechanism of postoperative residual pain and the clinical and experimental research progress of TCM treatment methods to explore the best treatment ideas for clinical workers.

Jiangjiang Lin, Longwang Tan. Clinical research progress of Chinese medicine in the treatment of residual pain after osteoporosis vertebral compression fractures surgery. International Journal of Frontiers in Medicine (2023), Vol. 5, Issue 4: 36-43. https://doi.org/10.25236/IJFM.2023.050407.

[1] Rachner T D, Khosla S, Hofbauer L C. Osteoporosis: now and the future [J]. The Lancet, 2011, 377(9773): 1276.

[2] KLAZEN C A, LOHLE P N, DE VRIES J, et al. Vertebroplasty versus conservative treatment in acute osteoporotic vertebral compression fractures (Vertos II): an open-label randomised trial [J]. Lancet (London, England), 2010, 376(9746): 1085-92.

[3] MCGIRT M J, PARKER S L, WOLINSKY J P, et al. Vertebroplasty and kyphoplasty for the treatment of vertebral compression fractures: an evidenced-based review of the literature [J]. The spine journal : official journal of the North American Spine Society, 2009, 9(6): 501-8.

[4] LI Y, HUANG M, CHEN J, et al. The Impact of Facet Joint Violation on Clinical Outcomes After Percutaneous Kyphoplasty for Osteoporotic Vertebral Compression Fractures [J]. World neurosurgery, 2018, 119: e383-e8.

[5] LAYTON K F, THIELEN K R, KOCH C A, et al. Vertebroplasty, first 1000 levels of a single center: evaluation of the outcomes and complications [J]. AJNR American journal of neuroradiology, 2007, 28(4): 683-9.

[6] MEI X, SUN Z Y, ZHOU F, et al. Analysis of Pre- and Postoperative Pain Variation in Osteoporotic Vertebral Compression Fracture Patients Undergoing Kyphoplasty [J]. Medical science monitor : international medical journal of experimental and clinical research, 2017, 23: 5994-6000.

[7] Liang Li, Wei Hongyu. Causes and countermeasures of unrelieved pain after vertebroplasty in patients with osteoporotic vertebral fractures [J]. Contemporary Medicine, 2018, 24(03): 83-5.

[8] Hou Wanxing, Li Hongwei, Zheng Xin, et al. Correlation between preoperative magnetic resonance imaging findings and bone cement leakage after percutaneous vertebral augmentation [J]. Chinese Journal of Tissue Engineering Research, 2022, 26(04): 504-9.

[9] HUANG Gang, LIANG Xu. Curative Effect Analysis of Osteoporotic Compression Fractures with Intercostal Neuralgia Treated by Needle Knife Therapy Combined with Bloodletting Therapy [J]. Journal of Liaoning University of Traditional Chinese Medicine, 2019, 21(06): 185-8.

[10] Qiao S.W., Deng Q., Li C.F. et al. Research Progress of Bone Cement Leakage after PKP for Osteoporotic Vertebral Compression Fractures [J]. Medical Recapitulate, 2021, 27(16): 3226-31.

[11] LIN E P, EKHOLM S, HIWATASHI A, et al. Vertebroplasty: cement leakage into the disc increases the risk of new fracture of adjacent vertebral body [J]. AJNR American journal of neuroradiology, 2004, 25(2): 175-80.

[12] Song G, Wu CHG, Cheng YD. et al. The correlation between the injection volume of bone cement and relevant biomechanics in percutaneous vertebroplasty: current status and research progress [J]. Journal of Interventional Radiology, 2018, 27(01): 87-90.

[13] Wang Yiya, Zhang Han, Lan Hai. Digital evaluation of finite element model for percutaneous kyphoplasty with bone cement injection [J]. Chinese Journal of Tissue Engineering Research, 2020, 24(09): 1378-1383.

[14] XIAO Qinghua, LIN Xiaosheng, ZHANG Zhen, WANG Hongbo. Research progress in the evaluation of diffusion and distribution of bone cement after vertebral augmentation [J]. 2021, 27(03): 440-5.

[15] Xie H, Li JC, He J et al. Study on the effect of the distribution of bone cement on the efficacy of vertebroplasty [J]. Chinese Journal of Orthopaedics, 2017, 37(22): 1400-6.

[16] TANG Guang-man, TANG Ke, ZHANG Ye. The influence of bone cement distribution on clinical efficacy of PKP in treatment of OVCF and recurrence of adjacent vertebral fractures [J]. Chinese Journal of Bone and Joint, 2022, 11(01): 54-7.

[17] KRAUSE W R, KRUG W, MILLER J. Strength of the cement-bone interface [J]. Clinical orthopaedics and related research, 1982, (163): 290-9.

[18] LIBICHER M, APPELT A, BERGER I, et al. The intravertebral vacuum phenomen as specific sign of osteonecrosis in vertebral compression fractures: results from a radiological and histological study [J]. European radiology, 2007, 17(9): 2248-52.

[19] HADLEY C, AWAN O A, ZOARSKI G H. Biomechanics of vertebral bone augmentation [J]. Neuroimaging clinics of North America, 2010, 20(2): 159-67.

[20] GRAHAM J, AHN C, HAI N, et al. Effect of bone density on vertebral strength and stiffness after percutaneous vertebroplasty [J]. Spine, 2007, 32(18): E505-11.

[21] Liu YF, Li Q, Wu W et al. Analysis of factors associated with chronic low back pain after PKP for osteoporotic thoracolumbar compression fractures [J]. Journal of Chinese Physician, 2019, 21(12): 1860-3.

[22] Yang Junsong, Chen Hao, Liu Peng, Liu Tuanjiang, Liu Jijun, Zhang Zhengping, He Baorong, Yan Liang, Zhang Haiping, Zhao Yuanting, Zhang Jianan, Huang Dageng, Hao Dingjun. Causes of residual back pain at early stage after percutaneous vertebroplasty [J]. Chinese Journal of Orthopaedics, 2020, 40(10): 625-34.

[23] MENG Sheng-wei, JIANG Sheng-dan, JIANG Lei-sheng. Research progress on causes of low back pain after vertebral augmentation for osteoporotic vertebral compression fractures [J]. Journal of Spinal Surgery, 2017, 15(02): 117-22.

[24] VOORMOLEN M H, LOHLE P N, JUTTMANN J R, et al. The risk of new osteoporotic vertebral compression fractures in the year after percutaneous vertebroplasty [J]. Journal of vascular and interventional radiology : JVIR, 2006, 17(1): 71-6.

[25] YANG S, LIU Y, YANG H, et al. Risk factors and correlation of secondary adjacent vertebral compression fracture in percutaneous kyphoplasty [J]. International journal of surgery (London, England), 2016, 36(Pt A): 138-42.

[26] SPROSS C, AGHAYEV E, KOCHER R, et al. Incidence and risk factors for early adjacent vertebral fractures after balloon kyphoplasty for osteoporotic fractures: analysis of the SWISSspine registry [J]. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2014, 23(6): 1332-8.

[27] YAN Y, XU R, ZOU T. Is thoracolumbar fascia injury the cause of residual back pain after percutaneous vertebroplasty? A prospective cohort study [J]. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2015, 26(3): 1119-24.

[28] WANG F, TONG T, MIAO D C, et al. Clinical correlation between osteoporotic thoracolumbar vertebral compression fractures and lumbar spondylolisthesis [J]. International orthopaedics, 2022.

[29] JEON I, KIM S W, YU D. Paraspinal muscle fatty degeneration as a predictor of progressive vertebral collapse in osteoporotic vertebral compression fractures [J]. The spine journal : official journal of the North American Spine Society, 2022, 22(2): 313-20.

[30] LIU Tao, ZHOU Quan, ZHANG Jun-xin, WANG Fei, ZHANG Wan-li, Yerzatei Tailaitihua, LIU Hao, YANG Hui-lin. Factors related to late persistent lumbosacral pain secondary to percutaneous kyphoplasty for osteoporotic vertebral compression fracture [J]. Orthopedic Journal of China, 2021, (23): 1-5.

[31] BU Bin, BU Linlin, WANG Yan. Effects of Zoledronic Acid Combined with Bushen Huoxue Decoction on Bone Mineral Density and Biochemical Markers of Bone Metabolism in Patients with OVCF during Recovery Period [J]. Chinese Journal of Surgery of Integrated Traditional and Western Medicine, 2021, 27(02): 233-236.

[32] HU Jingnuan, SUN Xiaona, ZHANG Baofeng. Effects Modified Bushen Huoxue Decoction on Promoting Postoperative Bone Healing in Patients with Osteoporotic Vertebral Compression Fracture [J]. World Chinese Medicine, 2020, 15(17): 2602-2607.

[33] ZHANG Jiewen, FENG Shaowen, CHEN Shaozhen. Effect of adjuvant therapy of bone broth on fracture healing after vertebroplasty in patients with osteoporotic thoracic and lumbar compression fractures [J]. Journal of Chinese Medicinal Materials, 2017, 40(08): 1972-1974.

[34] TANG Baoming, LI Zhaowei, YANG Airong, et al. Effect of Jingui Shenqiwan Combined with Fracture Three-stage Syndrome Differentiation on Recovery of Patients with Osteoporotic Vertebral Compression Fractures After Operation [J]. Chinese Journal of Experimental Traditional Medical Formulae, 2020, 26(20): 105-110.

[35] KONG Lingcheng, SHI Zhenyu, YAO Jianliang et al. Clinical study of the tonic bone decoction for the treatment osteoporotic vertebral compression fractures [J]. Chinese Journal of Osteoporosis, 2016, 22(09): 1159-63.

[36] FAN Xinfu, LI Qing, PENG Junyu. Study on the efficacy of Yaobikang granule combined with calcitriol on spinal fragility fracture after percutaneous vertebroplasty [J]. Chinese Journal of Osteoporosis, 2022, 28(01): 52-55.

[37] LE Jin, YIN Peiyu, HAN Tingliang et al. Clinical Study on Qiangjin Zhuanggu Pills Combined with PKP Therapy for Treatment of Osteoporotic Vertebral Compression Fractures [J]. Chinese Journal of Information on Traditional Chinese Medicine, 2018, 25(05): 32-35.

[38] ZHANG Yanyan, SU Kunzhi, QIN Xiaoyan. Clinical efficacy of Fairy Bone Capsules combined with calcium carbonate and calcitriol in postmenopausal patients with postmenopausal osteoporotic vertebral compression fracture PVP proprietary [J]. Chinese Traditional Patent Medicine, 2022, 44(02): 683-685.

[39] LIU Baoxin, CAI Yingfeng, CHEN Bing, et al. Effects of Traditional Chinese Medicine Paste and Baduanjin Combined with Calcium on Vertebral Re-fracture of Patients with Osteoporotic Vertebral Compression Fractures after Percutaneous Vertebroplasty [J]. Chinese Journal of Integrated Traditional and Western Medicine, 2021, 41(04): 448-455.

[40] ZHANG Zhen, LIN Xiaosheng, HAN Linjing et al. Effects of acupoint application therapy with Fuyuan Rugao in the treatment of residual low back pain in patients with OVCF after PKP [J]. Chinese Journal of Osteoporosis, 2020, 26(10): 1509-13.

[41] PENG Nan, XIAO Siwang. Effect of internal and external application of traditional Chinese medicine combined with functional exercise on pain and functional recovery after PKP for osteoporotic vertebral compression fractures [J]. China Modern Doctor, 2022, 60(05): 89-93.

[42] ZHAO Hai-ling, ZHOU Zong-bo, LI Jian-qiang, HUANG Jian, CHENG Yi, LU Zhi-fu. Clinical Observation of Jiawei Bushen Huoxuetang Combined with Fumigation of Traditional Chinese Medicine After Operation of Vertebral Compression Fracture [J]. Chinese Journal of Experimental Traditional Medical Formulae, 2019, 25(08): 95-100.

[43] CHEN Ping, WANG Hai-dong, LI Xiang-jun, TIAN Xue-mei. Clinical observation of postoperative complications and quality of life of PKP in treating osteoporotic thoracolumbar vertebral compression fractures with silver needle [J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2021, 36(01): 602-605.

[44] HUANG Mi, DU Shiyang, FENG Jing et al. Efficacy of PKP and acupuncture in the treatment of osteoporosis compression fracture with intercostal neuralgia: a prospective study [J]. Lishizhen Medicine and Materia Medica Research, 2016, 27(03): 647-649.

[45] Hou Xiaoyun, Xu Shihong, Dai Zhiyong, Yang Jiangxia. Analysis on application value of Fu’s subcutaneous needling for intercostal pain after surgery of osteoporotic thoracic vertebral compression fracture [J]. Acupuncture Research, 2021, 46(4):326-329350.

[46] LIANG Dongbo, LI Jianfeng, WANG Liping. Clinical observation of small needle knife in the treatment of residual low back pain after PVP surgery [J]. Guangdong Medical Journal, 2017, 38(14): 2233-6.