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International Journal of Frontiers in Medicine, 2023, 5(4); doi: 10.25236/IJFM.2023.050415.

Study of topical fluoride combined with semiconductor laser for the prevention of dental enamel caries


Wenxian Fan1, Kai Feng1, Xinshang Li1,2

Corresponding Author:
Wenxian Fan

1Department of Endodontics, the First Affiliated Hospital of Xinjiang Medical University (Affiliated Stomatological Hospital), Urumqi, 830054, China

2Institute of Stomatology, Urumqi, Xinjiang Uygur Autonomous Region, 830054, China


The prevention of dental caries is one of the main goals of modern dentistry. Other major goals include remineralization of caries, rather than the traditional "drill and fill". Remineralization is a restorative process that restores minerals and occurs daily through the presence of calcium, phosphate and fluoride in the saliva. Enamel demineralization occurs when acids produced by bacteria attack the enamel. A dynamic balance between enamel demineralization and remineralization is maintained under normal conditions, and disruption of this balance leads to progression of the lesion and eventually to cavitation formation. Fluoride plays an important role in enhancing remineralization. Topical application of fluoride is one of the most effective ways to stop or prevent dental caries. Fluoride ions can replace the hydroxyl group in hydroxyapatite, which leads to the formation of fluorapatite. The solubility of fluorapatite in acid is lower than that of hydroxyapatite. The effect of laser irradiation on the prevention of dental caries has been reported by numerous scholars. Studies have shown that when fluoride, calcium or phosphorus ions are present, laser irradiation can effectively enhance the acid resistance of tooth enamel by altering its chemical or morphological structure and promoting the remineralization process. Laser combined with fluoride has good effect and easy operation compared with other methods for caries prevention, and this paper will review the research on laser combined with fluoride in caries prevention in recent years.


Caries; Laser; Fluoride; Mineralization

Cite This Paper

Wenxian Fan, Kai Feng, Xinshang Li. Study of topical fluoride combined with semiconductor laser for the prevention of dental enamel caries. International Journal of Frontiers in Medicine (2023), Vol. 5, Issue 4: 91-96. https://doi.org/10.25236/IJFM.2023.050415.


[1] Salah R, Afifi RR, Kehela HA, et al. Efficacy of Novel Bioactive Glass in the Treatment of enamel white spot lesions: a randomized controlled trial [J]. J Evid Based Dent Pract 2022, 22(4): 101725.

[2] Mathirat A, Dalavi PA, Prabhu A, et al. Remineralizing Potential of Natural Nano-Hydroxyapatite Obtained from Epinephelus chlorostigma in Artificially Induced Early Enamel Lesion: An In Vitro Study [J]. Nanomaterials (Basel) 2022, 12(22).

[3] Memarpour M, Abedinzade A, Rafiee A, et al.Penetration ability and microhardness of infiltrant resin and two pit and fissure sealants in primary teeth with early enamel lesions [J]. Sci Rep 2022, 12(1):4652.

[4] Ogawa Y, Sayed M, Hiraishi N, et al. Effect of Surface Pre-Reacted Glass Ionomer Containing Dental Sealant on the Inhibition of Enamel Demineralization [J]. J Funct Biomater 2022, 13(4).

[5] Damian L-R, Dumitrescu R, Alexa VT, et al. Impact of Dentistry Materials on Chemical Remineralisation/Infiltration versus Salivary Remineralisation of Enamel-In Vitro Study [J]. Materials (Basel) 2022, 15(20).

[6] Tavares J dP, da Silva CV, Engel Y, et al. In situ Effect of CO2 Laser (9.3 μm) Irradiation Combined with AmF/NaF/SnCl2 Solution in Prevention and Control of Erosive Tooth Wear in Human Enamel [J]. Caries Res 2021, 55(6): 617-628.

[7] Eissa NM, Elshourbagy EM, Gomaa NE. Effect of sodium fluoride plus tricalcium phosphate with and without CO2 laser on remineralization of white spot lesions [J]. Heliyon 2022, 8(10): e10752.

[8] Tisler CE, Moldovan M, Petean I, et al. Human Enamel Fluorination Enhancement by Photodynamic Laser Treatment [J]. Polymers (Basel) 2022, 14(14).

[9] Kim HR, Son K, Son Y-T, et al. A Comparative Immunohistochemical Study of Wound Healing after Dental Diode Laser Treatment in the Rat Oral Mucosa [J]. Bioengineering (Basel) 2022, 9(9).

[10] Moslemi M, Nadalizadeh S, Mojahedi M, et al.Effect of Enamel Pretreatment Using Er,Cr:YSGG Laser Irradiation on Micro-shear Bond Strength of a Self-etch Fissure Sealant [J]. Photochem Photobiol 2022, 98(6): 1459-1463.

[11] Labunet A, Tonea A, Kui A, et al. The Use of Laser Energy for Etching Enamel Surfaces in Dentistry-A Scoping Review [J]. Materials (Basel) 2022, 15(6).

[12] Fazlyab M, Esmaeili Shahmirzadi S, Esnaashari E, et al. Effect of low-level laser therapy on postoperative pain after single-visit root canal retreatment of mandibular molars: A randomized controlled clinical trial [J]. Int Endod J 2021, 54(11): 2006-2015.

[13] Yang C, Wang X, Wang Y. Effect of diode laser combined with minocycline hydrochloride in nonsurgical periodontal therapy: a randomized clinical trial [J]. BMC Oral Health 2022, 22(1):71.

[14] Ahmed DRM, Shaath DG, Alakeel JB, et al. Influence of Diode Laser for the Treatment of Dentin Hypersensitivity on Microleakage of Cervical Restorations [J]. Biomed Res Int 2021, 2021: 9984499.

[15] Wawrzyk A, Rahnama M, Sofińska-Chmiel W, et al. The Use of the Diode Laser against the Microbiome on Composites Closing the Screw Access Hall (Sah) in the Reconstruction of Dental Implants: Ex Vivo Studies [J]. Int J Environ Res Public Health 2022, 19(12).

[16] Shim SH, Lee SY, Lee J-B, et al. Antimicrobial photothermal therapy using diode laser with indocyanine green on Streptococcus gordonii biofilm attached to zirconia surface [J]. Photodiagnosis Photodyn Ther 2022, 38: 10276

[17] Luk K, Niu JY, Gutknecht N, et al. Preventing Enamel Caries Using Carbon Dioxide Laser and Silver Diamine Fluoride [J]. Photobiomodul Photomed Laser Surg 2021, 39(4): 297-302.

[18] Zhao IS, Xue VW, Yin IX, et al. Use of a novel 9.3-μm carbon dioxide laser and silver diamine fluoride: Prevention of enamel demineralisation and inhibition of cariogenic bacteria [J]. Dent Mater 2021, 37(6): 940-948.

[19] Teutle-Coyotecatl B, Contreras-Bulnes R, Rodríguez-Vilchis LE, et al. Effect of Surface Roughness of Deciduous and Permanent Tooth Enamel on Bacterial Adhesion [J]. Microorganisms 2022, 10(9).

[20] Albalawi FS. Efficacy of Er, Cr: YSGG laser phosphoric acid gel and Riboflavin activated by Photodynamic therapy on enamel reconditioning rebonded to metallic brackets: An Invitro study [J]. Photodiagnosis Photodyn Ther 2022, 40:103043.

[21] Pourhajibagher M, Keshavarz Valian N, Bahador A. Theranostic nanoplatforms of emodin-chitosan with blue laser light on enhancing the anti-biofilm activity of photodynamic therapy against Streptococcus mutans biofilms on the enamel surface [J]. BMC Microbiol 2022, 22(1): 68.

[22] Chen L, Hontsu S, Komasa S, et al. Hydroxyapatite Film Coating by Er:YAG Pulsed Laser Deposition Method for the Repair of Enamel Defects [J]. Materials (Basel) 2021, 14(23).

[23] Dias-Moraes MC, Castro PAA, Pereira DL, et al. Assessment of the preventive effects of Nd:YAG laser associated with fluoride on enamel caries using optical coherence tomography and FTIR spectroscopy [J]. PLoS One 2021, 16(7): e0254217.

[24] Yin IX, Yu OY, Zhao IS, et al. Inhibition of dentine caries using fluoride solution with silver nanoparticles: An in vitro study [J]. J Dent 2020, 103:103512.

[25] Zhao IS, Yin IX, Mei ML, et al. Remineralising Dentine Caries Using Sodium Fluoride with Silver Nanoparticles: An In Vitro Study [J]. Int J Nanomedicine 2020, 15: 2829-2839.

[26] Al-Maliky MA, Frentzen M, Meister J. Artificial caries resistance in enamel after topical fluoride treatment and 445nm laser irradiation [J]. Biomed Res Int 2019: 9101642.

[27] Shetty C, Shetty A, Hegde MN, et al. Evaluation of surface microhardness of teeth after remineralizing with Sodium fluoride with functionalized tricalcium phosphate in combination with Indium-Garnet-Arsenide Laser: an in vitro study [J]. Res J Pharm Biol Chem Sci 2018; 9: 1205–1210. 

[28] Moharam LM, Sadony DM, Nagi SM. Evaluation of diode laser application on chemical analysis and surface microhardness of white spots enamel lesions with two remineralizing agents. [J]. Clin Exp Dent 2020; 12: e271–e276. 

[29] Al-Maliky MA, Frentzen M, Meister J. Combined effects of a topical fluoride treatment and 445nm laser irradiation of enamel against a demineralization challenge: a light and electron microscopic ex vivo study [J]. PLoS One 2020; 15: e0237195. 

[30] Kato IT, Kohara EK, Sarkis JE et al. Effects of 960-nm diode laser irradiation on calcium solubility of dental enamel: an in vitro study [J]. Photomed Laser Surg 2006; 24: 689–693.

[31] Wawrzyk A, Łobacz M, Adamczuk A, et al. The Efficacy of a Diode Laser on Titanium Implants for the Reduction of Microorganisms That Cause Periimplantitis [J]. Materials (Basel) 2021, 14(23).

[32] Hameed MS, Alkahtani ZM, Ajmal M, et al. Bond assessment of enamel conditioned with Er, Cr: YSGG laser and methylene blue photosensitizer activated by photodynamic therapy to orthodontic metallic brackets [J]. Photodiagnosis Photodyn Ther 2021, 36:102513.

[33] Mocuta Bojoga D-E, Grad Buriac O, Mateas M, et al. Comparative Evaluation of Influence of Nd:YAG Laser (1064 nm) and 980 nm Diode Laser on Enamel around Orthodontic Brackets: An In Vitro Study [J]. Medicina (Kaunas) 2022, 58(5).

[34] Sufaru I-G, Martu M-A, Luchian I, et al. The Effects of 810 nm Diode Laser and Indocyanine Green on Periodontal Parameters and HbA1c in Patients with Periodontitis and Type II Diabetes Mellitus: A Randomized Controlled Study [J]. Diagnostics (Basel) 2022, 12(7).

[35] Dembowska E, Jaroń A, Homik-Rodzińska A, et al. Comparison of the Treatment Efficacy of Endo-Perio Lesions Using a Standard Treatment Protocol and Extended by Using a Diode Laser (940 nm) [J]. J Clin Med 2022, 11(3).

[36] Imamura H, Zhu W, Adachi T, et al. Raman Analyses of Laser Irradiation-Induced Microstructural Variations in Synthetic Hydroxyapatite and Human Teeth [J]. J Funct Biomater 2022, 13(4).

[37] Sufaru I-G, Martu M-A, Luchian I, et al. The Effects of 810 nm Diode Laser and Indocyanine Green on Periodontal Parameters and HbA1c in Patients with Periodontitis and Type II Diabetes Mellitus: A Randomized Controlled Study [J]. Diagnostics (Basel) 2022, 12(7).

[38] Xue VW, Yin IX, Niu JY, et al. Effects of a 445 nm diode laser and silver diamine fluoride in preventing enamel demineralisation and inhibiting cariogenic bacteria [J]. J Dent 2022, 126: 104309.