Academic Journal of Medicine & Health Sciences, 2023, 4(5); doi: 10.25236/AJMHS.2023.040501.
Zhang Hui1, Dong Bo2, Ma Ani2, Kang Wulin2, Liu Deyu2
1The First School of Clinical Medicine, Shaanxi University of Traditional Chinese Medicine, Xianyang, Shaanxi, 712046, China
2Hospital of Orthopaedic Injuries, Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine, Xianyang, Shaanxi, 712000, China
Deep vein thrombosis is a disorder of venous return caused by abnormal intravascular coagulation, which has a high perioperative incidence in orthopedic patients and can develop into venous thrombosis syndrome and even fatal pulmonary embolism in severe cases. As a specific marker of thrombosis, D-dimer is widely used in diagnosing perioperative deep vein thrombosis in fractures, but its specificity in clinical diagnosis is low. It is often necessary to combine dynamic monitoring, ultrasound, Wells score, fibrinogen, and homocysteine to improve the accuracy of diagnosis. The authors have searched the literature and compiled a review of the latest research on D-dimer in diagnosing and managing deep vein thrombosis for clinical reference.
D-dimer; perioperative fracture; deep vein thrombosis; diagnosis
Zhang Hui, Dong Bo, Ma Ani, Kang Wulin, Liu Deyu. Research progress of D-dimer in the diagnosis of perioperative lower limb deep vein thrombosis in fracture. Academic Journal of Medicine & Health Sciences (2023) Vol. 4, Issue 5: 1-5. https://doi.org/10.25236/AJMHS.2023.040501.
 Zhou Jie, Liu Ming, Zhang Yudong, Wang Mingchao, Zhang Lu, Wang Jiayi. Clinical research progress of Chinese medicine in lower limb deep vein thrombosis [J]. Chinese Journal of Integrated Chinese and Western Medicine Surgery, 2021, 27(04):648-650.
 Gu S Q, Pi H Y, Song M, Gao Y. A review of the mechanism and application of mechanical prevention of deep vein thrombosis [J]. Journal of the PLA Medical College, 2021, 42(12):1326-1329.
 Johnson Eric D, Schell John C, Rodgers George M. The D-dimer assay. [J]. American journal of hematology, 2019, 94(7).
 Zhang Chengqing, Yang Xiaohong. Research progress on the diagnostic value of D-dimer in venous thromboembolism [J]. Xinjiang Medicine, 2019, 49(11): 1143-6.
 Farm M,Siddiqui A J,Onelöv L,Järnberg I,Eintrei J,Maskovic F,Kallner A,Holmström M,Antovic J P. Age-adjusted D-dimer cut-off leads to more efficient diagnosis of venous thromboembolism in the emergency department: a comparison of four assays.[J]. Journal of thrombosis and haemostasis : JTH,2018,16(5).
 Nybo Mads, Hvas AnneMette. Age-adjusted D-dimer cut-off in the diagnostic strategy for deep vein thrombosis: a systematic review [J]. Scandinavian Journal of Clinical and Laboratory Investigation, 2017, 77(8).
 Chengwu Han, Yongqiang Zhao, Wenli Cheng, Jing Yang, Jie Yuan, Yuehong Zheng, Xueying Yu, Tienan Zhu. The performance of age-adjusted D-dimer cut-off in Chinese outpatients with suspected venous thromboembolism [J]. Thrombosis Research, 2015, 136(4).
 Hu Wang, Utku Kandemir, Ping Liu, Hong Zhang, Pengfei Wang, Binfei Zhang, Kun Shang, Yahui Fu, Chao Ke, Yan Zhuang, Xing Wei, Zhong Li, Kun Zhang. Perioperative incidence and locations of deep vein thrombosis following specific isolated lower extremity fractures[J]. Injury, 2018, 49(7).
 Zhang Wenjuan, Huai Ying, Wang Wei, Xue Kaiyue, Chen Lei, Chen Chu, Qian Airong. A Retrospective cohort study on the risk factors of deep vein thrombosis (DVT) for patients with traumatic fracture at Honghui Hospital. [J]. BMJ open, 2019, 9(3).
 Li Y, Ding Na. Clinical significance of dynamic monitoring of plasma D-dimer levels during the perioperative period in patients with fractures [J]. Contemporary Medicine, 2020, 26(22):70-72.
 Huang Yan, Wang Liping, Cao Yanhong. The value of dynamic monitoring of D-dimer in the assessment of perioperative lower limb deep vein thrombosis in patients with lower limb fractures[J]. Chinese contemporary medicine, 2020, 27(34):182-184+254.
 Iyama Keita, Inokuma Takamitsu, Sato Shuntaro, Yamano Shuhei, Tajima Goro, Hirao Tomohito, Tasaki Osamu. Novel screening criteria for post-traumatic venous thromboembolism by using D-dimer. [J]. Acute medicine & surgery, 2019, 6(1).
 Niu F, Bao Zhao Hui, Gao Qian Kun, Geng Duan. The value of D-dimer combined with Wells score in the diagnosis of deep vein thrombosis after spinal surgery [J]. Experimental and Laboratory Medicine, 2020, 38(02):266-268.
 Tanapong Panpikoon, Songpol Chuntaroj, Tharintorn Treesit, Orapin Chansanti, Chinnarat Bua-ngam. Lower-Extremity Venous Ultrasound in DVT-Unlikely Patients with Positive D-Dimer Test [J]. Academic Radiology, 2020 (prepublish).
 Gao B, Zheng Tigang, Liu Baoping, Xu Wenyan, Gao Yan, Zhang Cuimei.The relationship between C-reactive protein, D-dimer and Wells score and postoperative deep vein thrombosis in patients with spinal fracture and its diagnostic value analysis[J]. Modern Biomedical Progress, 2021, 21(11): 2164-2168.DOI:10.13241/j.cnki.pmb. 2021.11.036.
 Zhu H, Cao J, Feng L T, Guo Ruiya. Application of colour Doppler ultrasound combined with plasma D-dimer in the diagnosis of lower limb venous thrombosis [J]. Hainan Medicine, 2020, 31(03): 343-346.
 Kumagai Gentaro, Wada Kanichiro, Kudo Hitoshi, Asari Toru, Ichikawa Nana, Ishibashi Yasuyuki. D-dimer monitoring combined with ultrasonography improves screening for asymptomatic venous thromboembolism in acute spinal cord injury. [J]. The journal of spinal cord medicine, 2020, 43(3).
 Hang X, Wang CHG, Zhang SH, Yue YJ, Lu J. Value of colour Doppler ultrasound combined with D-dimer for screening of peripheral lower limb deep vein thrombosis[J]. Journal of Medical Imaging, 2020, 30(03):475-478.
 Pieters Marlien, Wolberg Alisa S. Fibrinogen and fibrin: An illustrated review.[J]. Research and practice in thrombosis and haemostasis, 2019, 3(2).
 Liu LQ, Zhang CHL, Qin HZ. Predictive value of combined serum fibrinogen and related products assay for lower limb deep vein thrombosis in postoperative orthopedic patients [J]. Journal of Precision Medicine, 2021, 36(05):404-406+410.DOI:10.13362/j.jpmed. 202105007.
 Yang D. W., Lin S.S., Cai W .J. Clinical significance of detecting fibrinogen and D-dimer in elderly people with deep vein thrombosis after lower limb fracture surgery [J]. Chinese contemporary medicine, 2018, 25(06):105-107.
 Lin N, Ke QQ, Jiang LY, Ou LZ, Liu DEM, Wu YY, Du QF. Research progress on the clinical application of homocysteine [J]. Chinese general medicine, 2021, 19(08):1358-1361. doi: 10. 16766/ j. cnki. issn.1674-4152. 002060.
 Shu JF, Huang YH, Li YP. The value of combined plasma D-dimer and homocysteine assay in the diagnosis of fracture complicating lower limb deep vein thrombosis [J]. Thrombosis and Haemostasis, 2021, 27(05):843-844.
 Zhang L, Li YG, Cui ZQ, Chen CH, Ma JB, Zhi LQ. Effect of hyperhomocysteinemia on the occurrence of deep vein thrombosis after orthopaedic surgery [J]. Western Medicine, 2020, 32(10): 1500-1503