Stroke is one of the most common diseases in neurology, and the brain edema after stroke is an important factor affecting the prognosis of patients. It is particularly important to reduce the volume of brain edema in clinic. By studying the mechanism of Tongfu agent, it is shown that it can effectively reduce the water content of brain tissue by inhibiting the expression of AQP-4, reducing the permeability of blood-brain barrier and reducing the damage of inflammatory molecules, and it has achieved good curative effect in clinic, which is one of the common treatment methods for brain edema.

Xiaoli Meng, Haizhe Zhou. Application of dredging fu-organs in cerebral edema after stroke. Academic Journal of Medicine & Health Sciences (2023) Vol. 4, Issue 5: 84-89. https://doi.org/10.25236/AJMHS.2023.040514.

[1] Zhou Mengling, Wu Fengzhi, Han Chenxia, et al. Clinical application of "Tongfa" in traditional Chinese medicine [J]. Modern Chinese Medicine Clinical, 2016, 23(6):55-58.

[2] Wang Meimei, Jiang Linfang. Analysis on the clinical application of the method of dredging fu organs [J], World Latest Medical Information Abstracts, 2018, 18(88):247-248.

[3] Wei Xia, Liu Xiangzhe. Application of purgation in acute stroke [J]. Henan Traditional Chinese Medicine, 2002, 22(1):73-76.

[4] Zhao Dexi, Yao Jinwen. Application of Sanhua Decoction in Acute Stroke [J]. Journal of changchun university of traditional chinese medicine, 2006, 22(4):23.

[5] Liu Jianhong. Sanhua Decoction in Treating 28 Cases of Acute Ischemic Stroke [J]. Western Traditional Chinese Medicine, 2011, 24(7):61-63.

[6] Li Ying, Lu Yongchang. General situation of treating apoplexy by dredging fu-organs [J]. Journal of Shandong College of Traditional Chinese Medicine, 1990,(01):69-71.

[7] Gao Zuming. Analysis on the Treatment of Acute Ischemic Stroke by Purging Fu [J]. Chinese Medicine Forum, 2001, (03):17.

[8] Huang Peixin, Chen Hongxia. Treatment of cerebral edema in acute stroke with traditional Chinese medicine [J]. journal of emergency in traditional chinese medicine, 1998,7(1):36-37.

[9] Meng Xu. Overview of TCM research on acute cerebral edema after stroke [J]. Journal of Shandong University of Traditional Chinese Medicine, 2007, 31(5):439-441.

[10] Guo Jianwen, Zhang Xiaoyun, Lan Wancheng, et al. Professor Chen Shaohong's "Mechanism of the Core Disease of Stroke" [J]. Tianjin Traditional Chinese Medicine, 2006, 23(1):7-9.

[11] Yang Aixue. Clinical Study on the Treatment of Cerebral Edema in Acute Stroke with Xingnao Huatan Tongfu Decoction [J]. Journal of traditional Chinese medicine, 1993(2):92-94.

[12] Ren Li, Sun Shanquan. Progress in pathophysiology of ischemic brain edema [J]. Journal of Neurosurgery of Foreign Medical Neurology, 2003, 30(5):423-427.

[13] Wang Xiaojun. Theoretical discussion and experimental study on the protective effect of resuscitation and purgation on acute brain injury [D]. Shandong University of Traditional Chinese Medicine, 2004.

[14] Jin Na, Zhang Guohua. Formation mechanism and treatment progress of brain edema after cerebral hemorrhage [J]. Medical Review, 2017, 23(12):2380-2389.

[15] Zhang Changguo, Zheng Guoqing, Huang Hanjin, et al. Mechanism of Sanhua decoction in improving aquaporin -4 in ischemic brain edema [J]. China Journal of Integrated Traditional Chinese and Western Medicine, 2007, 14(6):352-356.

[16] Fan Kaifang, Tang Yingxue, Li Xiaoliang, et al. Effects of Sanhua Decoction on neurological function, brain water content and pathological changes of brain tissue in rats with cerebral ischemia-reperfusion [J]. Chinese journal of experimental traditional medical formulae, 2011, 17(24):159-162.

[17] Li Yongquan. Analysis of the law of Chinese medicine in treating cerebral edema after cerebral hemorrhage based on data mining [D]. Guangzhou University of Chinese Medicine, 2019.

[18] Tang Yuping, Cai Dingfang, Liu Jun, et al. Study on the mechanism of rhubarb improving the blood-brain barrier injury in rats with acute cerebral hemorrhage [J]. China Journal of Integrated Traditional Chinese and Western Medicine, 2006,2(26):152-156.

[19] Peng Shaopeng, Liu Jianxiong, Cui Qingrong, et al. Effects of emodin on aquaporin -4 and brain edema in perihematoma brain tissue of rats with cerebral hemorrhage [J]. Journal of Traditional Chinese Medicine, 2017,45(5):67-71.

[20] Chen Fengting, Hu Hairong. Clinical study on the effect of Tongfu mixture combined with western medicine routine on acute cerebral edema after massive cerebral infarction [J]. Journal of External Treatment of Traditional Chinese Medicine, 2017, 26(5):22-23.

[21] Zhang Yong. Clinical study on "Tongfu Xiezhuo Formula" promoting postoperative recovery of cerebral hemorrhage [J]. Jiangsu Traditional Chinese Medicine, 2012, 44(12):31-32.

[22] Cong Dawei, Zhang Xuefeng. Clinical observation on treating senile severe cerebral hemorrhage with Tongfu Xiezhuo recipe [J]. Modern journal of integrated traditional chinese and western medicine, 2017,26(07):770-772.

[23] Sun Shaogang. Effect of purgation on hematoma absorption and neurological function in acute cerebral hemorrhage [J]. Chinese medicine modern distance education of china, 2013, 11(11):17-19.

[24] Li Junhong. Dachengqi Decoction in Treating 35 Cases of Cerebral Edema in Acute Stroke [J]. Journal of emergency in traditional chinese medicine, 2006(07):770.

[25] Zhang Qiqi, Gao Junpeng, Cai Dingfang. Clinical observation of rhubarb in treating acute cerebral hemorrhage [J]. China Clinical Medicine, 2011, 18(03):293-295.