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Academic Journal of Medicine & Health Sciences, 2023, 4(6); doi: 10.25236/AJMHS.2023.040603.

Research progress on drug-related falls in the elderly


Xiao Qian1, Wen Xiulin2, Wang Jingrong1, Luo Liqun1, Su Liuju1

Corresponding Author:
Wen Xiulin

1School of Nursing, Shaanxi University of Chinese Medicine, Xianyang Shaanxi, 712046, China

2The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China


Falls are the leading cause of injury death in the elderly, and medication is one of the important adjustable factors that cause falls in the elderly. Strengthening medication management is of great significance to reduce the incidence of falls in the elderly. This paper systematically reviews the relevant literature from three aspects: the types of fall-related drugs in the elderly, the fall risk assessment scale and the prevention of drug-related falls, in order to provide a theoretical basis for the safe medication management of the elderly, improve the safety of medication in the elderly, and reduce the occurrence of drug-related falls.


the elderly; safe medication; Fall; prophylaxis

Cite This Paper

Xiao Qian, Wen Xiulin, Wang Jingrong, Luo Liqun, Su Liuju. Research progress on drug-related falls in the elderly. Academic Journal of Medicine & Health Sciences (2023) Vol. 4, Issue 6: 15-21. https://doi.org/10.25236/AJMHS.2023.040603.


[1] Bian Pingda, Qian Sufeng, Ying Qifeng, et al. Common causes of fall-related fractures in the elderly [J]. Chinese Journal of Osteoporosis and Bone Mineral Diseases, 2014; ( 2): 161-162. 

[2] Lin S,Wang X,Wu GF.et al.Expert consensus on fall risk assessment in the elderly in China (draft)[J]. Chinese Journal of Geriatric Health Medicine, 2019, 17(04):47-48+50.

[3] Rankin A,Cadogan CA, In Ryan C, et al.. Core Outcome Set for Trials Aimed at Improving the Appropriateness of Polypharmacy in Older People in Primary Care[J]. J Am Geriatr Soc. 2018 Jul;66(6):1206-1212.

[4] Zhao Ming. Analysis of fall prevalence and risk factors in the elderly in two regions of Zhejiang Province [D]. Zhejiang University, 2017. 

[5] Yan Yuqin, Zhang Ping. Research progress on risk factors for falls and intervention strategies in the elderly in the community[J]. Practical Geriatrics, 2018, 32(08):710-712.

[6] Watanabe Jonathan H. Medication Use, Falls, and Fall-Related Worry in Older Adults in the United States. [J]. The Consultant pharmacist: the journal of the American Society of Consultant Pharmacists, 2016, 31(7): 385-393. 

[7] Wang Jiaqing, Liu Jing, Huang Jia. Drug Evaluation, 2012, 9(32):39-41.

[8] Xiao Li, Li Wei, Shao Liming. Chinese Journal of Medicinal Chemistry, 2016, 26(06):509-517. 

[9] Zhang Min, Fan Zhenwei. Chinese Journal of Endemic Disease Prevention and Control, 2017, 32(11):1241-1242. 

[10] Qin Zhaohui, Yu Pulin. Chinese Journal of Gerontology, 2009, 29(23):3099-3101. 

[11] Li Liuxiang, Huang Minyi, Liang Jiayu. Analysis of fall-related factors and nursing countermeasures in hospitalized psychiatric patients [J]. China Practical Medicine, 2018, 13(35):182-184. 

[12] Yu Chen and Allan Hicks and Alison E. While. Depression and related factors in older people in China: a systematic review [J]. Reviews in Clinical Gerontology, 2011, 22(1): 52-67. 

[13] Lu Jing, Feng Xiaorong, Huang Yuan, et al. Research progress on clinical application of antidepressants in the elderly [J]. West China Journal of Pharmacy, 2018, 33(04):435-439. 

[14] Carvalho AF, Sharma MS, Brunoni AR, et al. The Safety, tolerability and risks associated with the use of newer generation antidepressant drugs: A critical review of theliterature [J]. Psychother Psychosom, 2016, 85(5): 270-288. 

[15] Liu Qing, Dong Wenwei. Correlation between central nervous system medication and fall risk in the elderly [J]. Practical Drugs and Clinical Practice, 2015, 18(02):235-237. 

[16] Johnell K, Fastbom J. Antiepileptic drug use in community-dwelling and institutionalized elderly: a nationwide study of over 1, 300, 000 older people. [J]. European Journal of Clinical Pharmacology, 2011, 67(10):1069-1075. 

[17] Niu Qian, Liu Xiaohong. Research progress on the correlation between antiepileptic drugs and falls in the elderly [J]. Beijing Medical Journal, 2021, 43(06):535-538. 

[18] Ensrud K E, Blackwell T L, Mangione C M, et al. Central nervous system-active medications and risk for falls in older women. [J]. Journal of the American Geriatrics Society, 2002, 50(10):1629–1637. 

[19] T, Masud, M, et al. Central nervous system medications and falls risk in men aged 60-75 years: the Study on Male Osteoporosis and Aging (SOMA)[J]. Age & Ageing, 2012. 

[20] Meng Weiping, Wei Hong. Investigation on sedative hypnotic medicinal use in retired elderly in Fuzhou City[J]. Journal of Pharmacoepidemiology, 2007(01):33-35. 

[21] Yang Y, Sun Yange, Yan Yan, et al. Study on the use of sedative hypnotics in elderly patients with chronic diseases in the standardized management of the community[J]. Chinese Journal of General Practice, 2019, 22(13):1613-1617. 

[22] Liu Jia, Feng Ruijuan, Cui Xingyue, et al. Knowledge and behavior investigation on the safe use of sedative hypnotic drugs in outpatient elderly patients[J]. Journal of Nursing, 2016, 23(18):56-58. 

[23] Lin Jianyu, Zhang Ying, Sun Chao, et al. Analysis of causes and countermeasures of falls in elderly patients with sedative hypnosis drugs during hospitalization[J]. Chinese Journal of Geriatrics, 2017, 36(06):627-631. 

[24] Neutel CI, Hirdes JP, Maxwell CJ, et al. New evidence on benzodiazepine use and falls: the time factor. Age Ageing. 1996 Jul; 25(4):273-278. 

[25] Neutel CI, Perry S, Maxwell C. Medication use and risk of falls. Pharmacoepidemiol Drug Saf. 2002 Mar; 11(2):97-104. 

[26] Masnoon N, Shakib S, Kalisch-Ellett L, et al. What is polypharmacy? A systematic review of definitions. BMC Geriatr. 2017 Oct 10; 17(1):230. 

[27] Huang Yanan, Yang Xiaoxuan, Chen Xiao, et al. Research progress in the management of fall-related drugs in the elderly[J]. Chinese Journal of General Practice, 2021, 24(34):4409-4414. 

[28] Charlesworth C J, Smit E, Lee D S H, et al. Polypharmacy among adults aged 65 years and older in the United States:1988—2010[J]. J Gerontol A Biol Sci Med Sc, 2015, 70(8):989-995. 

[29] Wang Ru, Guo Daihong, Li Yuanyuan, et al. Investigation and analysis of polypharmacy therapy in 13175 outpatient elderly patients[J]. Chinese Journal of Drug Application and Monitoring, 2018, 15(04):223-226. 

[30] Morse JM, Black C, Oberle K, et al. A prospective study to identify the fall-prone patient[J]. Soc Sci Med, 1989, 28(1):81—86. 

[31] Eagle DJ, Salama S, Whitman D, et al. Comparision of three instruments in predicting accidental falls in selected inpatients in a general teaching hospital[J]. J Gerontol Nurs, 1999, 25(7):40—45. 

[32] McCollam ME. Evaluation and implementation of a re-search-based falls assessment innovation[J]. Nurs Clin North Am, 1995, 30(3):507—514. 

[33] McFarlane-Kolb H. Falls risk assessment, multitargeted intervention and the impact on hospital falls[J]. Int J Nurs Pract 2004, 10(5):199—206. 

[34] Zhou Jungui, Li Yajie, Fan Jianzhong. Reliability and validity of Morse fall assessment scale Chinese edition in hospitalized elderly patients in China[J]. Chinese Journal of Rehabilitation Medicine, 2012, 27(03):244-247+284. 

[35] Chow SK, Lai CK, Wong TK, et al. Evaluation of the Morse Fall Scale: applicability in Chinese hospital populations[J]. International Journal of Nursing Studies, 2007, 44(4):556-565. 

[36] Oliver D, Britton M, Seed P, et al. Development and evaluation of evidence based risk assessment tool(STRATIFY) to predict which elderly inpatients will fall: case-control and cohort studies[J]. BMJ Clinical Research, 1997, 315(7115):1049-1053. 

[37] Liu Lixiang, He Wenjing, Mo Beirong, et al. A systematic review of fall risk assessment tools in elderly hospitalized patients[J]. Chinese Journal of Nursing Management, 2019, 19(08):1146-1153. 

[38] Vermilion. Reliability and validity evaluation of the application of the Chinese Thomas fall risk assessment tool in elderly hospitalized patients in China[J]. Chinese Journal of Practical Nursing, 2014, 30(33):67-70. 

[39] Yi Yanzhi, Zheng Bowen, Tang Jingfang, et al. Clinical Application Of Chinese Version Of Stratify Fall Risk Assessment Form [J]. NURSING RESEARCH, 2018, 32(17):2764-2766. 

[40] Hendrich AL, Bender PS, Nyhuis A. Validation of the Hendrich II Fall Risk Model: a large concurrent case/control study of hospitalized patients. Appl Nurs Res. 2003 Feb; 16(1):9-21. 

[41] Zhang Congcong. Chinese and reliability and validity evaluation of Hendrich fall risk assessment scale [D]. Peking Union Medical College of China, 2010. 

[42] Wang Shanshan, Liu Yanhui, Huang Chunping. Reliability and validity of the Chinese edition of the fall risk assessment scale for elderly hospitalized patients[J]. Chinese Journal of Nursing, 2012, 47(10):927-929. 

[43] Song Mi, Pi Hongying, Xu Yue, et al. Research on fall assessment tools for the elderly[J]. China Medical Herald, 2020, 17(34):60-63. 

[44] Avin K G, Hanke T A, Kirk-Sanchez N, et al. Management of falls in community-dwellingolder adults: Clinical guidance statement from the academy of geriatric physical therapy of the american physical therapy association[J]. Physical Therapy, 2015, 95(6): 815-834. 

[45] Huang Lianjiao, Chen Zhiqing, Qin Zhihui. Application of project management team in reducing falls caused by high-risk drugs[J]. Nursing Practice and Research, 2016, 13(18):128-130. 

[46] Qin Zhaohui, Yu Lin, Wu Zhengzheng. Current status and progress of fall research in the elderly[J]. Chinese Journal of Geriatrics, 2005(09):711-714. 

[47] Zhang Qi. Pharmacological intervention effect of clinical pharmacists in the management of clinical irrational drug use[J]. Continuing Medical Education, 2022, 36(02):97-100. 

[48] Wang J, Chen Z, Song Y. Falls in aged people of the Chinese mainland: Epidemiology, risk factors and clinical strategies [J]. Ageing Research Reviews, 2010, 9(supp-S):S13-S17. 

[49] BLarsson.Guidelines for intervention in falls in the elderly at home (maintenance)[J]. Chinese Journal of Geriatric Health Medicine, 2018, 16(03):32-34. 

[50] Larsson TJ, HgvideML, SvanborgM, et al. Falls prevention through community intervention-a swedish example[J]. SafetySci, 2009:48(2):204-208. 

[51] Zhang Chun. Investigation and intervention evaluation of the current situation of the elderly fall prevention in a college community in Guangzhou[J]. Modern Hospital, 2013: 13(9):152-154. 

[52] Tao Yanling, Chen Juanhui, Guan Yumei, et al. Risk factors and prevention measures for falls in the elderly at home in the community[J]. Chinese Nursing Management, 2017, 17(7):910-914. 

[53] Ye Lixiao, Deng Yinghong, Zhang Min. Causes of falls in elderly patients and cognitive investigation on fall prevention[J]. Jilin Medical Journal, 2013, 34(16):3196-3197. 

[54] Feng Lei, Li Yunshu, Yang Jie, et al. Effects of motion sensing games based on virtual reality technology integrated into home dialysis exercise management on fall risk and quality of life of dialysis patients [J]. Chinese Journal of Blood Purification, 2021, 20(05):302-305+332.