Welcome to Francis Academic Press

Academic Journal of Medicine & Health Sciences, 2023, 4(6); doi: 10.25236/AJMHS.2023.040605.

Research progress on etiology, pathogenesis and treatment of gastric precancerous lesions

Author(s)

Jijia Zhang, Huanping Lin, Hanyue Xiong

Corresponding Author:
Huanping Lin
Affiliation(s)

Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China

Abstract

Pregastric cancer is a process of transformation from normal gastric mucosa to gastric cancer. At present, the incidence of pregastric cancer is increasing year by year. Chinese medicine has unique advantages in preventing pregastric cancer. This article reviews the etiology, pathogenesis and treatment progress of precancerous lesions of gastric cancer, and reveals the etiology of precancerous lesions of gastric cancer. The pathogenesis is spleen deficiency, liver depression, Yin deficiency, dampness and heat, blood stasis. The pathological factors include qi stagnation, phlegm dampness, poison and silt. The treatment is mainly reflected in invigorating the spleen and dredging the liver, dampening and removing blood stasis. In the aspect of modern medicine, mainly through anti-inflammatory acid inhibition, eradication of Helicobacter pylori, endoscopic submucosal dissection and other methods. In this paper, the current medical treatment of pregastric cancer was screened to improve the understanding of pregastric cancer and reduce the incidence of gastric cancer as much as possible.

Keywords

Pregastric cancer, Traditional Chinese Medicine, Research progress

Cite This Paper

Jijia Zhang, Huanping Lin, Hanyue Xiong. Research progress on etiology, pathogenesis and treatment of gastric precancerous lesions. Academic Journal of Medicine & Health Sciences (2023) Vol. 4, Issue 6: 28-36. https://doi.org/10.25236/AJMHS.2023.040605.

References

[1] Smyth E C, Nilsson M, Grabsch H I, et al. Gastric cancer[J]. Lancet, 2020,396(10251):635-648.

[2] Sun Kexin, Zheng Rongshou, Zhang Siwei, et al. Analysis of incidence and mortality of malignant tumors in subregions of China in 2015[J]. Chinese Oncology, 2019,28(01):1-11.

[3] Lin Cuili, Huang Jian, Chen Qin, et al. Treatment of gastric precancerous lesions from spleen and stomach humidity, heat, deficiency and stasis[J]. New Chinese Medicine, 2021,53(14):108-111.

[4] Li Yan, Hou Xinxin, Wang Yumin. Clinical effect of endoscopic submucosal dissection in the treatment of early gastric cancer and precancerous lesions[J]. Bethune Medical Journal, 2020, 18(03): 219-221.

[5] Sun Yueming, Chen Qin, Zheng Rong, et al. Discussion on the identification and treatment of gastric precancerous lesions from the perspective of "spleen as the guard"[J]. Journal of Traditional Chinese Medicine, 2021,36(12):2516-2520.

[6] Dai Huanghuang, Wang Changsong. An empirical analysis of the treatment of gastric precancerous lesions from the original hypothesis[J]. Journal of Tianjin University of Chinese Medicine, 2017, 36(04): 251-253.

[7] Li Leyi, Zhuo Juncheng, Xie Kaifeng, et al. Regulation of PI3K/Akt/HIF-1α pathway by strengthening the spleen and removing stasis and detoxification formula for gastric precancerous lesions in autophagy and apoptosis of gastric mucosal epithelial cells in rats [J]. New Drugs and Clinical Pharmacology of Traditional Chinese Medicines, 2021,32(10):1444-1451.

[8] Feng Xiaoke, Lin Zhenyan, Liu Xuan, et al. Effect of phlegm and stasis elimination formula in reversing gastric precancerous lesions and its effect on gastric juice exosome miRNA expression [J]. Journal of Modern Integrative Medicine, 2021,30(09):936-939.

[9] Zhang Dan, Wei Muxin, Wang Ping, et al. Clinical efficacy of phlegm and stasis elimination prescription in the treatment of precancerous lesions of gastric cancer[J]. Chinese Journal of Traditional Chinese Medicine, 2021,39(04):241-243.

[10] Shen Hong, Yang Lu. Clinical observation of spleen strengthening and qi formula in the treatment of gastric precancerous lesions in chronic atrophic gastritis[C]: The 23rd National Spleen and Stomach Disease Academic Exchange Conference of the Spleen and Stomach Disease Branch of the Chinese Association of Chinese Medicine, Haikou, Hainan, China, 2011.

[11] Zhang Xuan, Xu Jingyu, Qin Zhifeng, et al. Clinical evidence idea of treating gastric precancerous lesions from sputum[J]. China Journal of Information on Traditional Chinese Medicine, 2014, 21(03):99-100.

[12] Zhang Xuan, Xu Jingyu, Sun Dazhi, et al. Effects of sputum elimination and gastric formula on histopathology of gastric mucosa in rats with gastric precancerous lesions [J]. Jilin Journal of Traditional Chinese Medicine, 2017,37(06):601-603.

[13] Gan D, Xu A, Du H, et al. Chinese Classical Formula Sijunzi Decoction and Chronic Atrophic Gastritis: Evidence for Treatment Approach?[J]. Evid Based Complement Alternat Med, 2017, 2017: 9012929.

[14] Wang T, Feng Y, Wang H, et al. The Mechanisms of Sijunzi Decoction in the Treatment of Chronic Gastritis Revealed by Network Pharmacology[J]. Evid Based Complement Alternat Med, 2020, 2020: 8850259.

[15] Zhu Feiye, Xu Yanli. Xu Shan's experience in the treatment of gastric precancerous lesions in "He Weifa"[J]. Zhejiang Journal of Traditional Chinese Medicine, 2022,57(04):265-266.

[16] Liu Yingchu, Wang Hongbing. Li Qianzhi's experience in using Four Gentlemen's Tonga plus minus in the treatment of chronic atrophic gastritis[J]. Liaoning Journal of Traditional Chinese Medicine, 2022, 49(05):16-19.

[17] Zhai Yarong, Wu Yao, Qiu Xueying, et al. Discussion on the influence of traditional Chinese medicine on tumor regulation based on "spleen as the guard"[J]. World Journal of Traditional Chinese Medicine, 2022,17(08):1105-1109.

[18] Zhang Xiujuan. Introduction of Professor Wang Chujie's experience in the treatment of gastric precancerous lesions[J]. New Chinese Medicine, 2009,41(10):13-15.

[19] Pan Yingchun, Xu Li. Professor Xu Li's experience in reversing gastric precancerous lesions[J]. Journal of Modern Integrative Medicine, 2017,26(33):3745-3747.

[20] Liang Qiting, Yang Liangjun, Zheng Jiayi, et al. Discussion on the correlation between spleen deficiency mechanism and pyroptosis of gastric precancerous lesions based on the theory of "spleen as the official of advice"[J]. Chinese Journal of Traditional Chinese Medicine, 2020,35(05):2453-2456.

[21] Lin Huanping, Wang Feng, Zhou Xiaoyan, et al. Clinical experience of Professor Li Shouchao in the treatment of gastric precancerous lesions[J]. Shaanxi Journal of Traditional Chinese Medicine, 2021, 42(01):103-105.

[22] Wang Zhiyi, Zhao Luqing, Li Danyan. Zhang Shengsheng from the mutual conclusion of toxicity and stasis to treat gastric precancerous lesions[J]. Global Journal of Traditional Chinese Medicine, 2022, 15(04):622-625.

[23] Bai Yuning, Zhang Ping, Li Li, et al. Effects of Spleen Tongluo Detoxification Formula on Expression of COX-2, NF-κBp65 and Bcl-2 in Gastric Mucosa in Patients with Gastric Precancerous Lesions[J]. Chinese Journal of Integrative Medicine, 2015,35(02):167-173.

[24] Bai Yuning, Zhang Runshun, Zhu Yuling, et al. Identification and treatment of chronic atrophic gastritis and precancerous lesions from "splenic deficiency obstruction and poison damage"[J]. Journal of Traditional Chinese Medicine, 2013,54(01):26-28.

[25] Li Qianzhi, Liu Geng. Treatment of chronic atrophic gastritis due to deficiency[J]. Chinese Journal of Integrative Medicine and Digestion, 2019,27(11):803-805.

[26] Luo Mingchi, Xu Hongling. Clinical observation of invigorating qi and activating blood in the treatment of gastric precancerous lesions[J]. Journal of Tianjin College of Traditional Chinese Medicine, 2002(03):12-13.

[27] Li Sufan. Treatment of gastric precancerous lesions in 50 cases[J]. Traditional Chinese Medicine Forum, 2003(01):7.

[28] Yin Jing, Yi Jinyu, Xu Bo, et al. Blood stasis theory and diagnosis and treatment of chronic atrophic gastritis[J]. Chinese Journal of Traditional Chinese Medicine, 2019,37(03):624-627.

[29] Tian Jingjing, Yuan Hongxia. Treatment of gastric precancerous lesions based on "less yang as the pivot"[J]. Medical Theory & Practice, 2021,34(09):1619-1620.

[30] Jiang Minling, Fan Jianwei, He Wu. Efficacy and pathological observation of flavored Chai Peony Liujunfang in the treatment of gastric precancerous lesions[J]. Shizhen Chinese Medicine and Medicine, 2016,27(08):1928-1930.

[31] An Wei, Feng Yuhuo. Feng Yu's experience in identifying and treating gastric precancerous lesions [J]. Journal of Shaanxi College of Traditional Chinese Medicine, 2011,34(02):31-32.

[32] Qin Shanwen. Clinical observation of differential treatment of cancer pain by traditional Chinese medicine[J]. Guangming Traditional Chinese Medicine, 2008(09):1328-1329.

[33] Zhao Y, Sun Y, Wang G, et al. Dendrobium Officinale Polysaccharides Protect against MNNG-Induced PLGC in Rats via Activating the NRF2 and Antioxidant Enzymes HO-1 and NQO-1[J]. Oxid Med Cell Longev, 2019,2019:9310245.

[34] Wu Yan, Jiang Tingting, Zhao Qing, et al. Protective mechanism of Dendrobium dendrobium polysaccharide against aspirin induced GES-1 damage in human gastric mucosal epithelial cells[J]. Chinese Pharmacological Bulletin, 2017,33(10):1479-1480.

[35] Li D, Zhao L, Li Y, et al. Gastro-Protective Effects of Calycosin Against Precancerous Lesions of Gastric Carcinoma in Rats[J]. Drug Des Devel Ther, 2020,14:2207-2219.

[36] Zhang Y, Zhang J Q, Zhang T, et al. Calycosin Induces Gastric Cancer Cell Apoptosis via the ROS-Mediated  MAPK/STAT3/NF-κB Pathway[J]. Onco Targets Ther, 2021,14:2505-2517.

[37] Zhang T, Liu G Y, Cao J L, et al. Peimine-induced apoptosis and inhibition of migration by regulating reactive oxygen species-mediated MAPK/STAT3/NF-κB and Wnt/β-catenin signaling pathways in  gastric cancer MKN-45 cells[J]. Drug Dev Res, 2022,83(7):1683-1696.

[38] Ma X, Zhang Z, Qin X, et al. Therapeutic Effect of Curcumol on Chronic Atrophic Gastritis (CAG) and Gastric Cancer Is Achieved by Downregulating SDF-1α/CXCR4/VEGF Expression[J]. J Oncol, 2022, 2022:3919053.

[39] Ma X, Kong L, Zhu W, et al. Curcumol Undermines SDF-1α/CXCR4/NF-κB Signaling Pathway to Suppress the  Progression of Chronic Atrophic Gastritis (CAG) and Gastric Cancer[J]. Evid Based Complement Alternat Med, 2022,2022:3219001.

[40] Ding Zhishan, Jiang Fusheng, Gao Chengxian, et al. Effect of curcumin on experimental gastric ulcer in animals[J]. Chinese Journal of Traditional Chinese Medicine,2008,(10):2225-2226.

[41] Zhang Yu, Jiang Yuanyuan, Liang Qianping, et al. Effect of endoscopic submucosal dissection in patients with early gastric cancer and precancerous lesions[J]. Practical Clinical Medicine, 2021, 22(03): 17-19.

[42] Zhang Wei, Guo Qianqian. Efficacy of endoscopic submucosal dissection and endoscopic mucosal resection in the treatment of early gastric cancer and precancerous lesions[J]. Clinical Medicine, 2020,40(11):58-59.

[43] Höbel S, Baumbach R, Dautel P, et al. [Single centre experience of endoscopic submucosal dissection (ESD) in premalignant and malignant gastrointestinal neoplasia][J]. Z Gastroenterol, 2014, 52(2): 193-199.

[44] Hikichi T, Sato M, Watanabe K, et al. Oral rabeprazole administration on a procedure day suppresses bleeding after endoscopic submucosal dissection for gastric neoplasms[J]. Fukushima J Med Sci, 2014, 60(1):68-74.

[45] Jiang Ning, Huang Xuan, Fan Yihong, et al. Efficacy of Integrated Traditional Chinese and Western Medicine in the Treatment of Gastric Precancerous Lesions[J]. Chinese Journal of Traditional Chinese Medicine, 2015,33(01):149-154.

[46] Liu Shaokang, Zhu Zhengwu. Efficacy of phlegm and stasis decoction combined with Western medicine in the treatment of chronic atrophic gastritis in 45 cases[J]. Xinjiang Traditional Chinese Medicine, 2019,37(05):9-11.

[47] Liu Run, Zhang Lihong. Efficacy of gastric rejuvenation tablets combined with mosapride tablets in the treatment of chronic atrophic gastritis[J]. Evaluation and Analysis of Hospital Medication in China, 2018,18(09):1195-1197.

[48] Zhang Geping. Efficacy of Astragalus Jianzhong decoction combined with acupoint application in the treatment of chronic atrophic gastritis[J]. Journal of Shanxi Medicine, 2017,46(15):1850-1851.

[49] Yang Zongbao, Wang Chenguang, Chen Jiaolong, et al. Effect of moxibustion on proliferation factors of gastric mucosal cells in rats with chronic atrophic gastritis precancer[J]. Chinese Acupuncture, 2015,35(12):1269-1273.

[50] Liu C C, Chen J L, Chang X R, et al. Comparative metabolomics study on therapeutic mechanism of electro-acupuncture  and moxibustion on rats with chronic atrophic gastritis (CAG)[J]. Sci Rep, 2017, 7(1):14362.

[51] Xu J, Zheng X, Cheng K K, et al. NMR-based metabolomics Reveals Alterations of Electro-acupuncture Stimulations on  Chronic Atrophic Gastritis Rats[J]. Sci Rep, 2017,7:45580.

[52] Li Pengfei, Qiu Yuping, Huang Jianhui, et al. Clinical study of Banxia Diarrhea Heart Decoction combined with warm acupuncture in the treatment of chronic gastritis with spleen deficiency and gastric fever[J]. Journal of Practical Chinese Internal Medicine, 2022,36(09):61-63.

[53] Zhang Yuetao, Liu Jingsheng. Clinical study of raw gastric powder combined with warm acupuncture in the treatment of chronic atrophic gastritis[J]. Henan Journal of Traditional Chinese Medicine, 2022, 42(12):1917-1920.