Polycystic ovary syndrome is a common reproductive endocrine metabolic disease in adolescents and women of childbearing age, with 55% being severe and leading to infertility. Currently, the pathogenesis of this disease is not clear. Traditional Chinese medicine attributes this condition to dysfunction of the kidneys, liver, and spleen. This disease has multiple types of syndromes, mainly divided into kidney deficiency and blood stasis, spleen deficiency and phlegm dampness, liver depression and spleen deficiency and qi stagnation and blood stasis, and phlegm and blood stasis intermingling. The clinical manifestations of each syndrome type are different. In recent years, traditional Chinese medicine has achieved satisfactory results in treating this disease. Targeted treatment for the disease not only regulates endocrine and metabolic disorders in the body, but also has high drug safety. This article summarizes and analyzes clinical research on the treatment of polycystic ovary syndrome (PCOS) in traditional Chinese medicine by consulting ancient literature and modern medical journals. By using the literature review method, it summarized and analyzed the traditional Chinese medicine etiology, drug action mechanism, and positive effects of traditional Chinese medicine treatment for polycystic ovary syndrome.This provides a scientific theoretical basis for the prevention and treatment of PCOS in traditional Chinese medicine.

Qing Yan, Ke Luo, Rong Tang, Ge Wang, Fei Li. Research Progress of Traditional Chinese Medicine Therapy on PCOS. Academic Journal of Medicine & Health Sciences (2023) Vol. 4, Issue 6: 84-92. https://doi.org/10.25236/AJMHS.2023.040613.

[1] Yu Shuangshuang, Zhao Rui, Li Fang, et al. Clinical research progress on polycystic ovary syndrome and traditional Chinese medicine treatment [J]. Journal of Inner Mongolia Medical University, 2021, 43 (3): 328-332.

[2] Cui Linlin, Chen Zijiang. Introduction to diagnostic criteria and treatment guidelines for polycystic ovary syndrome [J]. International Journal of Reproductive Health/Family Planning, 2011,30 (5): 405-408.

[3] Tao Jianyu, Zhang Zhengyang, Liu Chunhong. Inflammatory mechanism of polycystic ovary syndrome and progress of traditional Chinese medicine intervention [J]. Journal of Clinical Chinese Medicine, 2020, 32 (3): 564-567.

[4] Wang Hao, Cheng Ling, Ding Yongfen, et al. Research progress in the treatment of polycystic ovary syndrome with traditional Chinese medicine [J]. Jilin Traditional Chinese Medicine, 2018, 38 (12): 1483-1487.

[5] Song Ying, Li Rong. Interpretation of the Chinese Diagnosis and Treatment Guidelines for Polycystic Ovarian Syndrome [J] Journal of Practical Obstetrics and Gynecology, 2018, 34 (10): 737-741.

[6] Lanma. Overview of Traditional Chinese Medicine Treatment for Polycystic Ovarian Syndrome [J]. World Journal of Traditional Chinese Medicine, 2012, 7 (3): 274.

[7] Li Hanmin. Theoretical system of "liver kidney homology" [J]. Journal of Traditional Chinese Medicine Management, 2007, 15 (3): 203-206.

[8] Fan Mingming, Wang Jianying, Han Fengjuan, et al. Exploration of Traditional Chinese Medicine in Polycystic Ovarian Syndrome [J]. World Journal of Integrated Traditional Chinese and Western Medicine, 2009, 4 (6): 446-448.

[9] Sun Weifeng, Liang Jing, Zhang Xianxian, et al. Clinical study on the treatment of insulin resistance in polycystic ovary syndrome with the method of tonifying the kidney, promoting blood circulation, and resolving phlegm [J]. Chinese Journal of Traditional Chinese Medicine, 2011,29 (9): 2018-2020.

[10] You Zhaoling, Yang Zhengwang, Fu Lingmei. Exploration of the treatment of polycystic ovary syndrome from kidney deficiency and blood stasis [J]. Journal of Hunan University of Traditional Chinese Medicine, 2005, 25 (5): 25-26.

[11] Tian Ying, Zhang Xiaofeng, Yang Jianbing. Discussion on the understanding of the pathogenesis and differentiation of polycystic ovary syndrome in traditional Chinese medicine [J]. Modern Chinese Medicine, 2006, 26 (6): 42-44.

[12] Guo Meizhen. Discussion on Traditional Chinese Medicine Research of Polycystic Ovarian Syndrome [J]. Chinese Journal of Basic Medicine of Traditional Chinese Medicine, 2012, 18 (10): 1073-1074+1076.

[13] Pang Baozhen, Pang Qingyang, Zhao Huanyun. Research progress in the treatment of polycystic ovary syndrome infertility with traditional Chinese medicine [J]. Chinese Journal of Sexual Sciences, 2009, 18 (10): 32-35.

[14] Sun Ye, Ren Qingling. Research progress in the pathogenesis of PCOS in traditional Chinese and Western medicine [J]. Contemporary Medical Journal, 2015, 13 (5): 155-157.

[15] Meng Ping, Gao Xiaojing, Fu Shuqing. Introduction of Fu Shuqing's Experience in the "Harmony Method" for the Diagnosis and Treatment of Polycystic Ovarian Syndrome by Dr. Jiang [J]. Chinese Medical Forum, 2014, 29 (4): 17-18.

[16] Sun Lili, Liu Chunli, Yang Weiling. Summary of Experiences of Famous Traditional Chinese Medicine in Treating Polycystic Ovarian Syndrome [J]. Journal of Clinical Chinese Medicine, 2014,26 (5): 447-449.

[17] Pan Wen, Li Mingming, Wang Xiaoping. The effect of Bushen Huayu Formula on hormone levels and blood sugar in rats with polycystic ovary syndrome and insulin resistance [J]. New Chinese Medicine, 2015, 47 (12): 222.

[18] Luo Shicun, Xu Zhipeng, Peng Xiaopeng. The effect of modified Cangfu Daotan Wan on ovarian morphology and sex hormone levels in rats with polycystic ovary syndrome [J]. Chinese Medical Information, 2014, 31 (3): 118.

[19] Zheng Jun, Xu Caifeng, Pei Chongzhong. Clinical observation on the treatment of polycystic ovary syndrome with Turong Bushen Formula [J]. Western Traditional Chinese Medicine, 2021,34 (9): 121-123.

[20] Qu Hong, Xu Caifeng, Zheng Jun, et al. The effect of Turong Bushen Formula on endometrial receptivity in infertility patients with polycystic ovary syndrome [J]. Gansu Science and Technology, 2020, 36 (13): 151-154.

[21] Jones M R, Chua A, Chen Y D I,et al. Harnessing expression data to identify novel candidate genes in polycystic ovary syndrome[J]. PLoS ONE,2011,6 (5):e20120.

[22] Yu Jin, Liu Luxi, Zhai Dongxia, et al. The status of inflammatory microenvironment in patients with polycystic ovary syndrome with damp heat syndrome of the liver channel and the improvement effect of the method of tonifying the kidney and clearing the liver [J]. Journal of Beijing University of Traditional Chinese Medicine, 2018,41 (8): 689-695.

[23] Lan Nan, Wang Shuang, Qiu Wenping, et al. Compound malt pills on IL-6 and TNF in PCOS model rats- α The impact of expression [J]. Pharmacology and Clinical Studies of Traditional Chinese Medicine, 2016,32 (3): 136-140.

[24] Chen Yangdi, Fu Ping, Xing Jia. Compound Xingxia Tang on tumor necrosis factor in phlegm dampness type polycystic ovary syndrome model mice-α, The effect of interleukin-6 [J]. Chinese Journal of Traditional Chinese Medicine, 2017,35 (7): 1813-1816+1935.

[25] Jiang Xiaolin, Zhang Lide, Teng Fei, et al. Combination of Metformin and Gexia Zhuyu Tang for TLR4/NF in Rats with Polycystic Ovarian Syndrome Insulin Resistance-κThe impact of the B signaling pathway [J]. Chinese Journal of Pathophysiology, 2018, 34 (1): 158-162.

[26] Shi Mingqing, Chen Liping, Lan Guancui, et al. Clinical observation on the efficacy of self-designed kidney tonifying and spleen strengthening formula in the treatment of polycystic ovary syndrome [J]. Chinese Journal of Traditional Chinese Medicine Science and Technology, 2018,25 (3): 373-375.

[27] Ovalle F, Azziz R. Insulin resistance, polycystic ovary syndrome, and type 2 diabetes mellitus[J]. Fert Steril, 2002. 77(6):1095.

[28] Hong Yanli, Wu Fei. Experimental study on the regulation of Akt pathway of insulin resistance in polycystic ovary syndrome by tonifying the kidney and resolving phlegm formula [J]. Chinese Journal of Integrated Traditional and Western Medicine, 2014,34 (2): 230.

[29] Zhang Ting, Guo Jianyou. The effect of decocted solution of Radix Rehmanniae on the expression of PI3K/PKB molecules in the insulin signaling pathway of polycystic ovary rats [J]. Chinese Journal of Traditional Chinese Medicine, 2015,40 (10): 2004.

[30] Jamilian M, Asemi Z. The Effects of Soy Isoflavones on Metabolic Status of Patients With Polycystic Ovary Syndrome. The Journal of clinical endocrinology and metabolism, 2016, 101(9): 3386-3394.

[31] Borzoei A. Effects of cinnamon supplementation on antioxidant status and serum lipids in women with polycystic ovary syndrome.Journal of traditional and complementary medicine, 2018, 8(1): 128-133.

[32] Cui Xuefang, Mo Xiaoyu. Treatment of 50 cases of polycystic ovary syndrome with hyperandrogenism using the method of tonifying the kidney and eliminating phlegm [J]. Jilin Traditional Chinese Medicine, 2012, 32 (4): 378.

[33] Kuek-S WW, Gui S. Efficacy of Chinese patent medicine Tian Gui Capsule in patients with polycystic ovary syndrome:a randomized controlled trial[J]. Zhong xi yi jie he xue bao= J ChinIntegr Med, 2011,9(9):965-972.

[34] Fan Haiying, Zhou Li, Song Jinmei, et al. Clinical Observation on the Treatment of Polycystic Ovarian Syndrome Infertility with Kidney Tonifying and Pregnancy Promoting Formula [J]. Sichuan Traditional Chinese Medicine, 2015, 33 (9): 145.

[35] Rhododendron. The ovulation promoting effect of Bushen Tiaojing decoction on infertility patients with polycystic ovary syndrome [J]. Chinese Journal of Experimental Prescriptions, 2015,21 (16): 171.

[36] Qiu Xuefeng. Clinical observation on traditional Chinese medicine intervention before in vitro fertilization embryo transfer in infertility patients with polycystic ovary syndrome of spleen kidney yang deficiency type [D]. Shandong: Shandong University of Traditional Chinese Medicine, 2018,7,29-30.

[37] Chen Changqian, Zeng Biying. Clinical study on early intervention of traditional Chinese medicine in pregnancy patients with polycystic ovary syndrome [J]. Journal of Clinical Chinese Medicine, 2019, 31 (6): 1114-1116.

[38] Zhang Xianlin, Liu Xianzhe. Exploration of the correlation between polycystic ovary syndrome and cardiovascular disease [J]. Modern Biomedical Progress, 2007 (8): 1256-1257.

[39] Wang Baolian. Clinical observation on acupuncture and moxibustion periodic therapy for ovulation disorder of PCOS with kidney deficiency and blood stasis [D]. Fuzhou: Fujian University of Traditional Chinese Medicine, 2020.

[40] Tao Shuzhen, Xue Lian. The effect of acupuncture on menstrual irregularities in patients with polycystic ovary [J]. World Latest Medical Information Digest, 2018, 18 (91): 163.

[41] Li Tong. Observation on the therapeutic effect of regulating the spleen and stomach acupuncture method on amenorrhea patients with polycystic ovary syndrome of spleen deficiency and phlegm dampness type [D]. Tianjin: Tianjin University of Traditional Chinese Medicine. 2020.

[42] Song Yixing, Li Yongkai. Clinical observation on the treatment of polycystic ovary syndrome with phlegm dampness combined with infertility using warm acupuncture combined with periodic therapy [J]. Shaanxi Traditional Chinese Medicine, 2017, 38 (8): 1076-1077.

[43] Li Jing, Zhang Ye. Clinical observation on the treatment of phlegm dampness type of polycystic ovary syndrome with Cangfu Daotan Decoction plus warming acupuncture and moxibustion [J]. Journal of Practical Traditional Chinese Medicine, 2019, 35 (10): 1189-1190.

[44] Li Mengyang. Effect of Bushen Tiaojing Decoction combined with warming acupuncture and moxibustion on ovulation rate and sex hormone level in patients with polycystic ovary syndrome [J]. Guangxi Traditional Chinese Medicine, 2019, 42 (4): 25-26.

[45] Wu Huifang, Liu Lei, Hu Liping. Overview of Clinical Application of Fire Needle Therapy [J]. Smart Health, 2019, 5 (32): 45-46.

[46] Wang Junru, Gao Qifang. Research progress on clinical application of fire needle therapy [J]. Chinese Journal of acupuncture and moxibustion and Moxibustion, 2016, 5 (1): 18-20.

[47] Wu Na. Clinical study on the effect of fire acupuncture on sex hormone levels in polycystic ovary syndrome [D]. Guangzhou: Guangzhou University of Traditional Chinese Medicine. 2016.

[48] Geng Yining. Effect of fire needle combined with Zuogui Shugan Decoction on ovulation and serum testosterone level in infertility patients with polycystic ovary syndrome [J]. Shanghai acupuncture and moxibustion Journal, 2020, 39 (4): 406-410.

[49] He Yuan, Huang Lijuan. Clinical observation on 35 cases of polycystic ovary syndrome treated with electroacupuncture combined with warm acupuncture and moxibustion [J]. Massage and Rehabilitation Medicine, 2020, 11 (5): 45-46.

[50] Yu Liqing, Cao Lianying, Xie Jing, et al. Study on the efficacy and mechanism of electroacupuncture in treating insulin resistant polycystic ovary syndrome [J]. China acupuncture and moxibustion, 2020, 40 (4): 379-383.

[51] Xu Ge, Zhang Andong, Wang Qian, et al. The effect of electroacupuncture at different acupoints on follicular development and related factors in rats with polycystic ovary syndrome [J]. Acupuncture Research, 2019, 44 (10): 740-746+751.

[52] He Yuan, Huang Lijuan. Clinical observation on 35 cases of polycystic ovary syndrome treated with electroacupuncture combined with warm acupuncture and moxibustion [J]. Massage and Rehabilitation Medicine, 2020, 11 (5): 45-46.

[53] Zhu Qiaoling, Lin Liyi, Nie Runqiu, et al. Clinical efficacy observation of acupoint catgut embedding in the treatment of obese polycystic ovary syndrome [J]. Journal of Guangzhou University of Traditional Chinese Medicine, 2012, 29 (3): 268-270.

[54] Pan Yongqin. Clinical observation on the treatment of obese polycystic ovary syndrome with Guiluo's Tiaozhou Formula combined with acupoint catgut embedding [D]. Nanning: Guangxi University of Traditional Chinese Medicine, 2020.

[55] Yao Yao, Fan Yi, Xia Min. Experience of Xia Min acupoint catgut embedding combined with Jianpi Xiaotan Tang in the treatment of obese polycystic ovary syndrome [J]. Clinical Research of Traditional Chinese Medicine, 2020, 12 (30): 118-120+124.

[56] Wu Jia. The efficacy and endocrine effects of acupoint catgut embedding intervention in obese polycystic ovary syndrome [J]. Clinical Research of Traditional Chinese Medicine, 2020, 12 (5): 60-61.

[57] Chen Kaiwen, Song Yang. The effect of acupoint catgut embedding on the expression of GLUT-4 and IRS-2 in the endometrium of rats with polycystic ovary syndrome and insulin resistance [J]. Journal of Guangzhou University of Traditional Chinese Medicine, 2018, 35 (3): 460-465.

[58] Chen Danshan, Huang Jianye. Clinical observation on the treatment of obese and non-obese polycystic ovary syndrome with thunder fire moxibustion combined with acupoint catgut embedding [J]. Clinical Journal of acupuncture and moxibustion and Moxibustion, 2019, 35 (1): 26-29.

[59] Li Ning, Zhang Yongxing. Overview of Traditional Chinese Medicine in Treating Polycystic Ovarian Syndrome [J]. Chinese Medical Record, 2017, 18 (3): 109-112.

[60] Li Fan, Chen Ying. Study on the therapeutic effect of timing ear point embedding beans on infertility caused by PCOS [J]. Journal of Shangluo University, 2020,34 (4): 37-40.

[61] Wu Yuanyuan, Dai Mengcheng, Fang Chaohui, et al. Fang Chaohui's experience in treating polycystic ovary syndrome using the theory of "Yang Hua Qi, Yin Shaping" combined with ear point embedding beans [J]. Journal of Shaanxi University of Traditional Chinese Medicine, 2019,42 (1): 23-26.