Lead is a powerful toxic metal that can accumulate continuously along the food chain in the corresponding target organs of organisms through enrichment, thereby causing damage to the growth and development of the body. Current research generally believes that there is no threshold for the damage caused by lead to the human body, that is, any dose of lead may have harmful effects on the human body, so the neurotoxicity caused by lead exposure still receives widespread attention. This article summarizes the current situation of lead exposure, studies on different levels of lead neurotoxicity in humans, cells, and animals, and susceptibility markers, hoping to provide scientific basis for further research on lead neurotoxicity and formulating reasonable prevention and control measures in the future.

Yumeng Li, Danni Huang, Liangrong Li, Rongna Rao, Qiaoyan Wei, Yi Sun. Research Progress in Lead Neurotoxicity. Academic Journal of Medicine & Health Sciences (2023) Vol. 4, Issue 6: 101-104. https://doi.org/10.25236/AJMHS.2023.040616.

[1] Hauptman M, Niles JK, Gudin, et al. Individual- and Community-Level Factors Associated With Detectable and Elevated Blood Lead Levels in US Children: Results From a National Clinical Laboratory. JAMA Pediatr. 2021; 175(12):1252-1260. 

[2] Obeng-Gyasi E. Sources of lead exposure in various countries. Rev Environ Health. 2019; 34(1): 25-34. 

[3] Yang S, Wang H, Wang L, etc. Status and evaluation of heavy metal lead pollution in 24 types of common vegetables in Haishu District, Ningbo [J]. Chinese Journal of Health Inspection 2022; 32(07): 862-865.

[4] Zhang W, Kang W, Jiang H. Determination of blood lead content in lead exposed workers by ICP-MS [J]. Chemical study. 2017; 28(02):169-172.

[5] Khalil N, Morrow LA, Needleman L, et al. Association of cumulative lead and neurocognitive function in an occupational cohort [J]. Neuropsychology, 2009, 23: 1019.

[6] Deng W, McKinnon RD, Poretz RD. Lead exposure delays the differentiation of oligodendroglial progenitors in vitro. Toxicol Appl Pharmacol. 2001; 174(3):235-244.

[7] Huang S., Weisskopf M. G., Bhramar M., et al. The Potential Influence of Variants of the SNCA Gene on the Impact of Cumulative Lead Exposure on Risk of Parkinson’s Disease. [(accessed on 3 July 2020)]; Available online: https://ehp.niehs.nih.gov/doi/10.1289/isee. 2013. P-2-26-18

[8] Liu Q, Hu J, Zhu Z, etc. Study on the correlation between programmed cell death factor 10 gene polymorphism and blood lead concentration [J]. Journal of Toxicology. 2019, 33(03):234-237.