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International Journal of Frontiers in Medicine, 2023, 5(6); doi: 10.25236/IJFM.2023.050602.

Research Progress on the Mechanism of Action of Maxing Shigan Decoction in the Treatment of Viral Pneumonia


Mingxing Dong1, Weihua Zhang2

Corresponding Author:
Weihua Zhang

1Shaanxi University of Traditional Chinese Medicine, Xianyang, Shaanxi, 712000, China

2Xianyang Children's Hospital/Xianyang Rainbow Hospital, Xianyang, Shaanxi, 712000, China


Viral pneumonia refers to the lung inflammation caused by a viral infection, the main causative agent is Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2), Influenza virus (Flu), parainfluenza virus (HPIV), adenovirus (Adv), respiratory syncytial virus (RSV), etc., Its main symptoms are fever, cough, shortness of breath, wheezing and wet lung rales, with changes in chest imaging (X-ray, ultrasound, CT, etc.), For the treatment of viral pneumonia, in addition to the treatment with influenza viruses that can be treated with neuraminidase inhibitors, no specific drugs for other viruses, Clinical mainly symptomatic treatment. Current studies have proved that the inflammatory cytokines IL-6, TNF-α; the stimulating molecule CD137 and the chemokine CXCL-10, and the signaling pathway NF-κB signaling pathway, TLR 4-MyD 88-TRAF-6 pathway effectively inhibit inflammatory response, promote viral clearance, and effectively treat viral pneumonia. Viral pneumonia belongs to the category of "pneumonia asthma" in traditional Chinese medicine. For its heat syndrome and demonstration, such as wind heat, phlegm heat, toxic fever and other syndrome types, it can be used as the basic prescription for addition and subtraction treatment.


Maxing Shigan Decoction; viral pneumonia; cytokines; stimulatory molecules; chemokines; signaling pathway

Cite This Paper

Mingxing Dong, Weihua Zhang. Research Progress on the Mechanism of Action of Maxing Shigan Decoction in the Treatment of Viral Pneumonia. International Journal of Frontiers in Medicine (2023), Vol. 5, Issue 6: 7-11. https://doi.org/10.25236/IJFM.2023.050602.


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