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International Journal of Frontiers in Medicine, 2023, 5(6); doi: 10.25236/IJFM.2023.050606.

Protective effect of tanshinone ⅡA, MAPK1, and RELA on ischemic injury after stroke


Huan Peng1, Chenming He1, Yunong Gui1, Chao Jiang2, Zhongjv Xu3, Fei Li1

Corresponding Author:
Chao Jiang

1Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, China, 712046

2The Second Affiliated Hospital of Xi'an Medical University, Shaanxi Key Laboratory of Brain Disorders, Xi'an, Shaanxi, 710038, China

3Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai, 200052, China


Stroke ischemic injury has become one of the major diseases threatening human health and life, and reducing the secondary damage of neurons after cerebral ischemia is an important measure to treat this disease. Inflammatory factors, oxidative stress, and excessive activation of microglia lead to the aggravation of ischemic nerve damage, and if not stopped in time, it will cause large-scale infarction of brain tissue, resulting in permanent neurological deficits. Studies have found that the use of tanshinone II. A can improve the occurrence of the above reactions by inhibiting the two targets of MAPK1 and RELA (p65). This way of inhibiting specific targets to reduce cerebral ischemic damage has become one of the hot issues in today's research. This article mainly reviews the mechanism of tanshinone II. A by inhibiting MAPK and NF-κB signaling pathways, reducing the inflammatory response, oxidative stress, and regulating microglial polarization.


cerebral ischemia; Tanshinone II.A; MAPK1; RELA(p65)

Cite This Paper

Huan Peng, Chenming He, Yunong Gui, Chao Jiang, Zhongjv Xu, Fei Li. Protective effect of tanshinone ⅡA, MAPK1, and RELA on ischemic injury after stroke. International Journal of Frontiers in Medicine (2023), Vol. 5, Issue 6: 28-33. https://doi.org/10.25236/IJFM.2023.050606.


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