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International Journal of Frontiers in Medicine, 2023, 5(6); doi: 10.25236/IJFM.2023.050614.

Research progress on the effect of intestinal flora changes on liver and kidney function in AIDS patients

Author(s)

Ma Mingjun1, Chen Panpan2, Xiao Shaotan2, Xin Xin2

Corresponding Author:
Xin Xin
Affiliation(s)

1School of Public Health, Dali University, Dali, Yunnan, 671000, China

2Shanghai Pudong New Area Center for Disease Control and Prevention, Pudong Institute of Preventive Medicine, Fudan University, Shanghai, 200136, China

Abstract

HIV, also known as HIV, infects the body's immune cells, causing immune deficiencies. The intestine is not only the immune organ of the human body, but also includes a large number of intestinal flora, and the intestinal microecology composed of these flora is closely related to immunity. HIV infection itself and its infection caused by intestinal flora imbalance, intestinal mucosal barrier destruction, causing the body's systemic inflammatory cascade reaction, the production of various inflammatory cytokines and metabolites, and eventually cause certain damage to liver and kidney function. This article reviews the mechanism and relationship between the effects of intestinal microbiota changes on liver and kidney function in AIDS patients, and changes the regulation of intestinal microbiota disorders on the microinflammatory state of the body, thereby providing a new entry point for the improvement of liver and kidney function in AIDS patients.

Keywords

HIV; Intestinal Flora; Inflammatory Cytokine; Gut-Liver Axis; Gut-Kidney Axis

Cite This Paper

Ma Mingjun, Chen Panpan, Xiao Shaotan, Xin Xin. Research progress on the effect of intestinal flora changes on liver and kidney function in AIDS patients. International Journal of Frontiers in Medicine (2023), Vol. 5, Issue 6: 89-96. https://doi.org/10.25236/IJFM.2023.050614.

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