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International Journal of Frontiers in Medicine, 2023, 5(7); doi: 10.25236/IJFM.2023.050701.

The Relationship between Intestinal Microflora and Coronary Heart Disease and the Research Status of Traditional Chinese Medicine Intervention


Wang Yiming1, Feng Lanshuan1, Zhang Jie2

Corresponding Author:
Wang Yiming

1Shaanxi University of Chinese Medicine, Xianyang, 712046, China 

2Affiliated Hospital of Integrated Traditional and Western Medicine of Shaanxi University of Chinese Medicine, Xi'an, 710000, China


Coronary heart disease (CHD) is a disease such as angina pectoris caused by lumen stenosis caused by coronary atherosclerosis. It is one of the cardiovascular diseases with high morbidity and mortality. The pathogenesis of the disease is very complex, and there are many inducing factors. Modern studies have shown that intestinal flora is a new target for the prevention and treatment of CHD. Inflammation caused by intestinal flora imbalance and its metabolites such as short-chain fatty acids (SCFAs), bile acids (BAs) and trimethylamine oxide (TMAO) can directly or indirectly affect the development of CHD. In recent years, Chinese medicine intervention on intestinal flora in the prevention and treatment of CHD has been a hot topic. Modern doctors have made many achievements in the use of traditional Chinese medicine to intervene intestinal flora in the prevention and treatment of CHD based on the theory of "heart-to-small intestine", the theory of homology of medicine and food, and the theory of acupuncture and moxibustion. This paper summarizes the research on the intervention of traditional Chinese medicine on intestinal flora in the prevention and treatment of CHD by consulting relevant contributions in Chinese and English in recent years. It is found that monomers or extracts of traditional Chinese medicine, Chinese medicine pairs and traditional Chinese medicine preparations can regulate the occurrence and development of CHD by interfering with intestinal flora, such as regulating the risk factors of CHD, such as blood glucose and blood lipids, or increasing the production of SCFAs to prevent atherosclerosis, reducing the production of TMAO and preventing thrombosis. It is expected that this discussion can provide a new idea for traditional Chinese medicine to interfere with intestinal flora in the prevention and treatment of CHD.


CHD; intestinal flora; TCM theory; mechanism; homology of medicine and food; traditional Chinese medicine

Cite This Paper

Wang Yiming, Feng Lanshuan, Zhang Jie. The Relationship between Intestinal Microflora and Coronary Heart Disease and the Research Status of Traditional Chinese Medicine Intervention. International Journal of Frontiers in Medicine (2023), Vol. 5, Issue 7: 1-6. https://doi.org/10.25236/IJFM.2023.050701.


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