Esophageal cancer (EC) is a common digestive tract tumor with high invasiveness and poor prognosis. According to global statistics in 2020, EC ranks 7th in incidence and 6th in mortality. Traditional treatment options include surgery, radiotherapy, and chemotherapy, but often produce adverse reactions, drug resistance, and poor prognosis. In recent years, tumor immunology has rapidly developed, and biological immune therapy has become a new treatment method. Oncolytic viruses (OV) have shown good therapeutic effects in the treatment of EC in recent years. Recombinant adenoviruses OBP-301 (telomelysin) and H101 are widely studied OVs in EC treatment. With the rapid development of tumor immunotherapy, OV therapy has become a research hotspot in the treatment of EC. This review article summarizes the mechanism of action of OVs and their research progress in the treatment of EC.

Kun Yang, Junhai Li. Recent Advances of Oncolytic Virus in Esophageal Cancer Therapy. International Journal of Frontiers in Medicine (2023), Vol. 5, Issue 7: 13-18. https://doi.org/10.25236/IJFM.2023.050703.

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