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International Journal of Frontiers in Medicine, 2023, 5(7); doi: 10.25236/IJFM.2023.050704.

Metabolomics in the Research of Viral Infectious Disease Mechanisms


Tingting Zhang1, Pengbo Yu2, Yaping Li3, Yufeng Zhang4, Huiling Deng1,5

Corresponding Author:
Huiling Deng

1School of Public Health, Shaanxi University of Chinese Medicine, Xianyang, China

2Department of Virus Disease Prevention and Control, Shaanxi Provincial Centre for Disease Control and Prevention, Xi'an, China

3Infectious Disease, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China

4Infectious Disease, Xi'an Children’s Hospital, Xi'an, China

5Childhood Infectious Disease, Xi'an Central Hospital, Xi'an, China


Viral invasion of the body causes metabolic changes involving pathways such as gluconeogenesis, amino acid metabolism, lipid metabolism, the TCA cycle, and energy metabolism and affects vital bodily processes such as nucleic acid, protein, and lipid synthesis. During antiviral therapy, the immune response is closely related to the metabolic balance, and numerous metabolites, including glycolytic metabolites, amino acids, and nucleotides, can influence the immune response. Monitoring metabolites by metabolomics technology can aid in continuously optimizing the efficacy of medications used to treat viral infectious diseases. It also provides diagnostic and prognostic value in the clinic, making it a valuable technological platform. This review concentrates on applying metabolomics technologies to study viral infectious disease pathogenesis and treatment.


Metabolomics; Viral Infectious Diseases; Hand-foot-mouth disease (HFMD); Influenza; Coronavirus disease 2019 (COVID-19)

Cite This Paper

Tingting Zhang, Pengbo Yu, Yaping Li, Yufeng Zhang, Huiling Deng. Metabolomics in the Research of Viral Infectious Disease Mechanisms. International Journal of Frontiers in Medicine (2023), Vol. 5, Issue 7: 19-26. https://doi.org/10.25236/IJFM.2023.050704.


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