In order to analyze the syndrome elements characteristics of spleen deficiency dampness stagnation syndrome in liver cirrhosis and liver cancer, and establish the syndrome differentiation standard of spleen deficiency dampness stagnation syndrome in liver cirrhosis and liver cancer. We enrolled a total of 1263 inpatients with hepatitis B cirrhosis and liver cancer from 8 hospitals including Shaanxi Traditional Chinese Medicine Hospital. TCM syndrome types were identified by syndrome differentiation and double-level frequency weight scissors algorithm, and the characteristic syndromes of spleen deficiency dampness and stagnation syndrome were calculated by logistic regression analysis. According to the inclusion criteria and exclusion criteria, the syndromes of spleen-deficiency and dampness-stagnation syndrome in 1263 medical records were extracted and analyzed one by one, and the characteristic syndromes were obtained: dizziness (OR=4.903), insomnia (OR=4.035); Characteristics of spleen deficiency and dampness in decompensated liver cirrhosis: yellow and white coat on tongue (OR=74.51), pulse number (OR=11.809), epigastric discomfort (OR=2.530); Characteristics of spleen deficiency dampness and stagnation syndrome of liver cancer: delayed pulse (OR=307.305), mobile dullness (OR=38.781), oliguria (OR=29.425), ascites (OR=4.533), splenomegasis (OR=2.112), (P<0.05). Resultly, it is thus clear that double frequency weight scissors algorithm and Logistic regression analysis have good diagnostic efficacy for the study of syndrome differentiation standard of spleen deficiency dampness and stagnation syndrome of liver cirrhosis and liver cancer.

Yizhe Tong. Study on the dialectical criterion of liver cirrhosis and liver cancer syndrome of spleen deficiency dampness and stagnation based on cohort study and double frequency weight scissors algorithm. International Journal of Frontiers in Medicine (2023), Vol. 5, Issue 7: 115-121. https://doi.org/10.25236/IJFM.2023.050718.

[1] Dong Jing, Zhang Jing, Zhang Han. The Application of the Thought of "Preventive Treatment of Disease" in the Prevention and Treatment of Hepatitis B [J]. Journal of New Chinese Medicine, 2012, 44(6):179-180.

[2] Wang Guiqiang, et al. The guideline of prevention and treatment for chronic hepatitis B: a 2015 update [J]. Journal of Clinical Hepatology, 2015, 31(12):1941-1960.

[3] Chinese Journal of Digestion. Expert consensus on diagnosis and treatment of hepatitis B cirrhosis (2014) [J]. Pharmaceutical and Clinical Research, 2014, 000(002):99-99. 

[4] Zhu Wenfeng. Study on Syndrome Factor Differentiation [J]. Henan Traditional Chinese Medicine, 2009,29(1):1-4. 

[5] Wei Beihai, et al. Program for Diagnosis and Treatment of Liver Cirrhosis with Integrative Chinese and Western Medicine (draft) [J]. Chinese Journal of Integrated Traditional and Western Medicine, 2004, 24(10):869-871. 

[6] Wu Mianhua, Wang Xinyue. Internal medicine of Traditional Chinese Medicine [M]. Beijing: Chinese Archives of Traditional Chinese Medicine, 2012.

[7] Ling Changquan, et al. Study of a qualitative diagnostic criterion for basic syndromes of traditional Chinese medicine in patients with primary liver cancer [J]. Journal of Chinese Integrative Medicine, 2005, 3(2):95-98. 

[8] Zhou Yang, et al. TCM syndrome study on 493 patients with chronic hepatitis and hepatic cirrhosis [J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2014, 29(12):3798-3801. 

[9] Bian Yanqin, Liu Ping, Sun Mingyu. The Pathogenesis of Dampness Heat Accumulation Syndrome of Liver Cirrhosis Based on the Theories of Chinese Formula and Syndrome [J]. Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology, 2020, 22(2):264-269. 

[10] Wang Ning, Chen Jianjie. Summary of Professor Chen Jianjie's Experience in Differentiating and Treating Ascites in the Decompensated Stage of Liver Cirrhosis [J]. Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases, 2019, 29(6):539-540. 

[11] Yu Wei. Origin about "stuffy fullness" in TCM [D]. Nanjing University of Traditional Chinese Medicine, 2008.

[12] Xia Ningjun, Zhang Yonghong. Experience in Traditional Chinese Medicine Syndrome Differentiation and Treatment of Primary Cancer [J]. Journal of Traditional Chinese Medicine, 2013, 54(14):1237-1239. 

[13] Wu Tongyu, et al. Study on the relationship between the syndrome factor dampness and Five-zang of primary hepatocellular carcinoma [J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2013, 28(1):75-77. 

[14] Pang Dexiang, He Ren. Exploration on professor HE Ren's formula in treating liver cancer with ascites [J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2010(2):248-250. 

[15] Wang Haiyan, Huo Jiege. Huo Jiege's Experience in Treating Cirrhotic Ascites from the Spleen Perspective [J]. Beijing Journal of Traditional Chinese Medicine, 2015, 34(8):634-636.