The purpose of this study is to explore the relationship between inflammatory active factors and traditional Chinese medicine (TCM) syndrome differentiation and classification of UC, and to provide a reference basis for the future treatment of this disease by combining traditional Chinese and Western medicine. We Collected 286 patients with Ulcerative colitis who were admitted to our hospital from January 2022 to April 2023 and met the diagnostic criteria. We classified the patients by disease stage, activity grade and lesion range, classified them according to their clinical data by TCM syndrome differentiation, and collected the measured values of peripheral blood erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and fecal calprotectin (FC), SPSS software was used to analyze the collected data, and 2-test, two independent sample t-test, one-way ANOVA and other methods were used to analyze, to explore the TCM syndrome types of Ulcerative colitis, and to analyze the correlation between the range of lesions, disease stages, activity grades and inflammatory activity factors of patients. The results showed that among 286 patients, there were 148 cases of dampness heat syndrome in the large intestine, with the highest proportion (51.75%), followed by 82 cases of spleen deficiency and dampness accumulation syndrome (28.67%), and 56 cases of liver depression and spleen deficiency syndrome (19.58%); The content of inflammatory activity factors (ESR, CRP, FC) in the large intestine dampness heat syndrome group was significantly higher than that in the other two syndrome types, while the content of inflammatory activity factors in the liver depression spleen deficiency syndrome group was slightly higher than that in the spleen deficiency dampness accumulation syndrome group (P<0.05). The content of inflammatory activity factors in the patients during the disease activity period was significantly higher than that in the clinical remission period (P<0.05); The content of inflammatory activity factors in the severe activity group was significantly higher than that in the mild and moderate activity groups, and there was no difference in the content between the moderate activity group and the mild activity group (P>0.05). In the range of lesion location, patients with extensive colon type have the highest expression of inflammatory activity factors, followed by the left colon type and the rectum type (P>0.05). The vast majority of patients in clinical remission stage have spleen deficiency and dampness accumulation syndrome, followed by liver depression and spleen deficiency syndrome, and a few patients have large intestine dampness heat syndrome; The main type of mild active phase patients is spleen deficiency and dampness accumulation syndrome, followed by large intestine dampness heat syndrome, and a few patients are spleen deficiency and liver stagnation syndrome; Both moderate and severe active stage patients are mainly characterized by large intestine dampness heat syndrome (P<0.05). Resultly, the levels of inflammatory activity factors in patients with ulcerative colitis can objectively reflect the clinical activity and severity of the disease. The vast majority of patients have dampness heat syndrome of the large intestine, which has higher predictive value.

Xiaoxiao Ren, Yibing Li. Analysis of the Correlation between Traditional Chinese Medicine Syndrome Types and Inflammatory Activity Factors in Ulcerative Colitis. International Journal of Frontiers in Medicine (2023), Vol. 5, Issue 7: 122-129. https://doi.org/10.25236/IJFM.2023.050719.

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