IgA nephropathy is the most common primary glomerular diseases globally, affecting approximately 1.3% of the global population. The pathogenesis is incompletely understood and it has a poor prognosis. The features of IgA nephropathy is IgA deposition in the glomerular mesangium, which initiates inflammatory cytokine release and complement activation. Previous studies have shown that the type of IgA deposited in the glomerulus is Gd-IgA1 and is involved in the occurrence and development of IgA nephropathy. At present, a large number of studies have shown that the activation of complement pathway plays an important role in the pathogenesis of IgA nephropathy, and is related to disease progress, especially the Lectin pathway and alternative pathway. This article mainly describes the relationship between alternative pathways and Galactose deficient IgA1 (Gd-IgA1) in the occurrence and development of IgA nephropathy.

Qijun Tian, Jian Shi. Exploration of IgA Nephropathy from the Perspective of Gd-IgA1 and Complement Alternative Pathway. International Journal of Frontiers in Medicine (2023), Vol. 5, Issue 8: 100-108. https://doi.org/10.25236/IJFM.2023.050814.

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