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Academic Journal of Medicine & Health Sciences, 2023, 4(8); doi: 10.25236/AJMHS.2023.040813.

Research Progress on the Relationship between Cuproptosis and Clinical Related Diseases

Author(s)

Wenxian An1, Yaying Xie2, Yuting Zhang1

Corresponding Author:
Yaying Xie
Affiliation(s)

1Inner Mongolia Medical University, Hohhot, China

2Department of Anesthesiology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China

Abstract

As a transition metal with REDOX properties, copper plays an indispensable role as an enzyme cofactor in a variety of biochemical processes. It is absorbed by small intestinal epithelial cells, transported in blood, stored in liver, and excreted in bile to maintain systemic copper homeostasis. However, when the excretion and absorption of copper in the body are unbalanced, such as the proportion of excretion, the copper concentration will exceed the upper limit of the cellular copper concentration threshold, which will lead to cell metabolism disorders, cell death, organ dysfunction, and a series of clinicopathological symptoms.

Keywords

Cuproptosis; Clinical diseases; Wilson’s disease; Menke’s disease

Cite This Paper

Wenxian An, Yaying Xie, Yuting Zhang. Research Progress on the Relationship between Cuproptosis and Clinical Related Diseases. Academic Journal of Medicine & Health Sciences (2023) Vol. 4, Issue 8: 76-80. https://doi.org/10.25236/AJMHS.2023.040813.

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