Welcome to Francis Academic Press

Academic Journal of Medicine & Health Sciences, 2023, 4(8); doi: 10.25236/AJMHS.2023.040813.

Research Progress on the Relationship between Cuproptosis and Clinical Related Diseases


Wenxian An1, Yaying Xie2, Yuting Zhang1

Corresponding Author:
Yaying Xie

1Inner Mongolia Medical University, Hohhot, China

2Department of Anesthesiology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China


As a transition metal with REDOX properties, copper plays an indispensable role as an enzyme cofactor in a variety of biochemical processes. It is absorbed by small intestinal epithelial cells, transported in blood, stored in liver, and excreted in bile to maintain systemic copper homeostasis. However, when the excretion and absorption of copper in the body are unbalanced, such as the proportion of excretion, the copper concentration will exceed the upper limit of the cellular copper concentration threshold, which will lead to cell metabolism disorders, cell death, organ dysfunction, and a series of clinicopathological symptoms.


Cuproptosis; Clinical diseases; Wilson’s disease; Menke’s disease

Cite This Paper

Wenxian An, Yaying Xie, Yuting Zhang. Research Progress on the Relationship between Cuproptosis and Clinical Related Diseases. Academic Journal of Medicine & Health Sciences (2023) Vol. 4, Issue 8: 76-80. https://doi.org/10.25236/AJMHS.2023.040813.


[1] Elizabeth A Rowland and Caroline K Snowden and Ileana M Cristea. (2018). Protein lipoylation: an evolutionarily conserved metabolic regulator of health and disease. Current Opinion in Chemical Biology, 42 pp. 76-85. 

[2] Spiegel R, Saada A, Halvardson J, et al. Deleterious mutation in FDX1L gene is associated with a novel mitochondrial muscle myopathy. Eur J Hum Genet. 2014; 22(7):902-906. 

[3] Vallières C, Holland SL, Avery SV. Mitochondrial Ferredoxin Determines Vulnerability of Cells to Copper Excess. Cell Chem Biol. 2017 Oct 19; 24(10):1228-1237. e3. 

[4] Tsvetkov P, Coy S, Petrova B, etal. Copper induces cell death by targeting lipoylated TCA cycle proteins. Science. 2022 Mar 18; 375(6586):1254-1261. 

[5] Jack H. Kaplan and Edward B. Maryon. How Mammalian Cells Acquire Copper: An Essential but Potentially Toxic Metal [J]. Biophysical Journal, 2016, 110(1): 7-13. 

[6] Bandmann O, Weiss KH, Kaler SG. Wilson's disease and other neurological copper disorders. Lancet Neurol. 2015 Jan; 14(1):103-13. 

[7] Mulligan C, Bronstein JM. Wilson Disease: An Overview and Approach to Management. Neurol Clin. 2020 May; 38(2):417-432. 

[8] CzłonkowskaA, RodoM, Wierzchowska-CiokA, et al. Accuracy of the radioactive copper incorporation test in the diagnosis of Wilson disease [J]. Liver Int, 2018, 38(10):1860-1866. 

[9] Shaonan L I , Dan Y U , Lianji W .Research progress on the relationship between obstructive sleep apnea syndrome and diseases of the respiratory and circulatory systems[J].Journal of Otolaryngology and Ophthalmology of Shandong University, 2019. 

[10] Jin Shan, Yang Wenming, Liu Kangwen, et al. Effect of high copper diet on cognitive function and hippocampal synaptic protein in rats [J]. Chinese Journal of Behavioral Medicine and Brain Science, 2021, 31(8):673-678. 

[11] Balleine BW, Delgado MR, Hikosaka O. The role of the dorsal striatum in reward and decision-making [J]. J Neurosc, 2007, 27(31):8161-8165. 

[12] Yang Lianyu, Wang Z. Relationship between copper and the regulation of hypothalamic growth [J]. Journal of Jilin Agricultural University, 2003 (1): 86-90. 

[13] Tiffany-Castiglioni E, Hong S, Qian Y. Copper handling by astrocytes: Insights into neurodegenerative disease [J]. Intern J Dev Near, 2011, 09(8):810-818. 

[14] Rivera-MancíaS, Pérez-NeriI, RíosC, et al. The transition metals copper and iron in neurodegenerative diseases [J]. Chem Biol Interact, 2010, 186(2):184. 

[15] Lin Jinxian, Wang Pan, Wu Xinmou, Lin Yuchun. Advances in the study of regulatory cell death induced by dysregulation of copper homeostasis and its regulation [J]. Journal of Jiangsu University (Medical Edition), 2021, 32(04):306-317. 

[16] Celia Arnaud. Copper regulates sleep [J]. Chemical & Engineering News, 2018. 

[17] Gonzalez-Lopez, Eugene, and Kent E Vrana. “Dopamine beta-hydroxylase and its genetic variants in human health and disease.” Journal of neurochemistry vol. 152, 2 (2020): 157-181. 

[18] Xiao Tong et al. “Copper regulates rest-activity cycles through the locus coeruleus-norepinephrine system.” Nature chemical biology vol. 14, 7 (2018): 655-663. 

[19] Rostkowska-Nadolska B, Posspiech L, Bochnia M. Content of trace elements in serum of patients with carcinoma of the larynx [J]. Arch Immunol Ther Exp(Warsz), 1999, 47(5):321-325

[20] Kuo HW, Chen SF, Wu CC, et al. Serum and tissue trace elements in patients with breast cancer in Taiwan [J]. Biol Trace Elem Res, 2002, 89(1):1-11

[21] Li X, Wang Y H, Ma X W. Research progress of 64CuCl 2 in the diagnosis and treatment of cancer and abnormal copper metabolism diseases [J]. Chin J Nuclear Medicine and Molecular Imaging, 2021, 41(2): 119-123. 

[22] Guo Ling, Liu Jing, Guo Qulian et al. Identification of anthocyanins of purple potato and screening and verification of potential anti-leukemia targets [J]. Guangxi Science, 2021, 29(05):949-958. 

[23] Garber Ken. “Cancer's copper connections.” Science (New York, N. Y.) vol. 349, 6244 (2015): 129. 

[24] Carreira-Barral I, Riopedre-Fernández M, de Blas A, et al. Ditopic binuclear copper (Ⅱ) complexes for DNAcleavage[J]. J Inorg Biochem, 2020, 205:110995.