To explore the relationship between Gut microbiota and post-stroke depression (PSD), and the mechanism of exercise training on post-stroke depression in rats. In this study, SPF grade rats were selected and fed adaptively for one week before the start of the experiment. At the same time, treadmill training was conducted for three days to screen rats that could complete the treadmill training program. Using random number table, 60 rats were divided into blank group, Sham surgery group, model group and intervention group, 15 rats in each group were given corresponding intervention treatment. The intervention group showed better performance in sugar preference tests (SPT) and forced swimming tests (FST) compared to the stroke group (p<0.001). In terms of the expression of inflammatory factors, it was also better than the model group (p<0.001). After exercise training, the expression levels of lactic acid bacteria and bifidobacteria in rats significantly increased. Exercise training can improve the performance of post-stroke depression rats, and its mechanism may be related to Gut microbiota.

Jiaen Yang, Ning Jia, Zixuan Ou, Guangjin Zhou, Wenxiao Ma. The Study on the Mechanism of Exercise Training Improving Symptoms of Poststroke Depression in Rats. Academic Journal of Medicine & Health Sciences (2023) Vol. 4, Issue 8: 99-104. https://doi.org/10.25236/AJMHS.2023.040816.

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