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Academic Journal of Medicine & Health Sciences, 2023, 4(8); doi: 10.25236/AJMHS.2023.040816.

The Study on the Mechanism of Exercise Training Improving Symptoms of Poststroke Depression in Rats


Jiaen Yang, Ning Jia, Zixuan Ou, Guangjin Zhou, Wenxiao Ma

Corresponding Author:
Jiaen Yang

Department of TCM Rehabilitation, The People’s Hospital of Gaoming District of Foshan City, Foshan, China


To explore the relationship between Gut microbiota and post-stroke depression (PSD), and the mechanism of exercise training on post-stroke depression in rats. In this study, SPF grade rats were selected and fed adaptively for one week before the start of the experiment. At the same time, treadmill training was conducted for three days to screen rats that could complete the treadmill training program. Using random number table, 60 rats were divided into blank group, Sham surgery group, model group and intervention group, 15 rats in each group were given corresponding intervention treatment. The intervention group showed better performance in sugar preference tests (SPT) and forced swimming tests (FST) compared to the stroke group (p<0.001). In terms of the expression of inflammatory factors, it was also better than the model group (p<0.001). After exercise training, the expression levels of lactic acid bacteria and bifidobacteria in rats significantly increased. Exercise training can improve the performance of post-stroke depression rats, and its mechanism may be related to Gut microbiota.


Exercise Training; Gut microbiota; Post stroke depression

Cite This Paper

Jiaen Yang, Ning Jia, Zixuan Ou, Guangjin Zhou, Wenxiao Ma. The Study on the Mechanism of Exercise Training Improving Symptoms of Poststroke Depression in Rats. Academic Journal of Medicine & Health Sciences (2023) Vol. 4, Issue 8: 99-104. https://doi.org/10.25236/AJMHS.2023.040816.


[1] WHO. Depression-Key facts. World Health Organization 2018. 

[2] WHO. Global Health Estimates 2016: Deaths by Cause, Age, Sex, by Country and by Region, 2000-2016. World Health Organization 2018. 

[3] WHO. Global Health Estimates. Geneva, World Health Organization 2012. 

[4] Feigin VL, Forouzanfar MH, Krishnamurthi R, Mensah GA, Connor M, Bennett DA, et al. Global and regional burden of stroke during 1990-2010: findings from the Global Burden of Disease Study 2010[J]. Lancet,2014,383(9913):245-254 

[5] Donkor ES. Stroke in the 21(st) Century: A Snapshot of the Burden, Epidemiology, and Quality of Life [J]. Stroke Res Treat, 2018, 2018:3238165. 

[6] Shi Y, Yang D, Zeng Y ,et al. Risk Factors for Post-stroke Depression: A Meta-analysis[J]. Front Aging Neurosci, 2017,11(9):218-229.

[7] Taylor-Rowan M, Momoh O, Ayerbe L, Evans JJ, Stott DJ and Quinn TJ. Prevalence of pre-stroke depression and its association with post-stroke depression: a systematic review and meta-analysis[J]. Psychol Med, 2019,49(4):685-696.

[8] Bartoli F, Pompili M, Lillia N, et al. Rates and correlates of suicidal ideation among stroke survivors: a meta-analysis[J]. J Neurol Neurosurg Psychiatry,2017,88 (6),498-504.

[9] Wang Z, Shi Y, Liu F,et al. Diversiform Etiologies for Post-stroke Depression[J].Front Psychiatry, 2019,23(9):761-774.

[10] Starkstein SE and Hayhow BD. Treatment of Post-Stroke Depression[J].Curr Treat Options Neurol,2019,21(7):31-43.

[11] Ayerbe L, Ayis S, Wolfe CD and Rudd AG. Natural history, predictors and outcomes of depression after stroke:systematic review and meta-analysis[J].BrJ Psychiatry, 2013,202(1):14-21.

[12] Hackett ML and Pickles K. Part I: frequency of depression after stroke: an updated systematic review and meta-analysis of observational studies[J]. Int J Stroke, 2014,9(8):1017-1025.

[13] Jorgensen TS, Wium-Andersen IK, Wium-Andersen MK, Jorgensen MB, Prescott E, Maartensson S, et al. Incidence of Depression After Stroke, and Associated Risk Factors and Mortality Outcomes,in a Large Cohort of Danish Patients[J].JAMA Psychiatry,2016,73(10):1032-1040.

[14] Mitchell AJ, Sheth B, Gill J, Yadegarfar M, Stubbs B, Yadegarfar M, et al. Prevalence and predictors of post-stroke mood disorders: A meta-analysis and meta-regression of depression, anxiety and adjustment disorder[J]. Gen Hosp Psychiatry, 2017,47:48-60.

[15] Cai W, Mueller C, Li YJ, Shen WD and Stewart R. Post stroke depression and risk of stroke recurrence and mortality: A systematic review and meta-analysis[J]. Ageing Res Rev, 2019,50:102-109.

[16] Serrano S, Domingo J, Rodriguez-Garcia E, Castro MD and del Ser T. Frequency of cognitive impairment without dementia in patients with stroke: a two-year follow-up study[J]. Stroke 2007;38(1):105-10.

[17] Blochl M, Meissner S and Nestler S. Does depression after stroke negatively influence physical disability? A systematic review and meta-analysis of longitudinal studies[J]. J Affect Disord, 2019, 247:45-56.

[18] Hilari K, Needle JJ and Harrison KL. What are the important factors in health-related quality of life for people with aphasia? A systematic review[J]. Arch Phys Med Rehabil, 2012,931 Suppl):S86-95.

[19] Bartoli F, Pompili M, Lillia N, Crocamo C, Salemi G, Clerici M, et al. Rates and correlates of suicidal ideation among stroke survivors: a meta-analysis[J]. J Neurol Neurosurg Psychiatry, 2017,88(6):498- 504.

[20] Rui L, Yingying Y, Haitang J, et al. A risk prediction model for post-stroke depression in Chinese stroke survivors based on clinical and socio-psychological features [J]. Oncotarget, 2017,8 (38):62891-62899.

[21] Dinan TG, Cryan JF. Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration[J]. J Physiol,2017, 595(2):489-503.

[22] ROSA E F, TAKAHASHI S, ABOULAFIA J, et al. Oxidative stress induced by intense and exhaustive exercise impairs murine cognitive function [J]. Journal of neurophysiology, 2007, 98(3): 1820-6.

[23] SCHNEIDER C A, RASBAND W S, ELICEIRI K W. NIH Image to ImageJ: 25 years of image analysis [J]. Nature methods, 2012,9(7): 671-5.

[24] ESPARRAGO LLORCA G, CASTILLA-GUERRA L, FERNANDEZ MORENO M C, et al. Post-stroke depression: an update [J]. Neurologia (Barcelona, Spain), 2015, 30(1): 23-31.

[25] HACKETT M L, PICKLES K. Part I: frequency of depression after stroke: an updated systematic review and meta-analysis of observational studies [J]. International journal of stroke : official journal of the International Stroke Society, 2014,9(8): 1017-25.

[26] KENDLER K S, GATZ M, GARDNER C O, et al. A Swedish national twin study of lifetime major depression [J]. The American journal of psychiatry, 2006,163(1): 109-14.

[27] FLASTER M, SHARMA A, RAO M. Poststroke depression: a review emphasizing the role of prophylactic treatment and synergy with treatment for motor recovery [J]. Topics in stroke rehabilitation, 2013,20(2): 139-50.

[28] ZHOU S, LIU S, LIU X, et al. Selective serotonin reuptake inhibitors for functional independence and depression prevention in early stage of post-stroke: A meta-analysis [J]. Medicine, 2020, 99(6): e19062.

[29] PAOLUCCI E M, LOUKOV D, BOWDISH D M E, et al. Exercise reduces depression and inflammation but intensity matters [J]. Biological psychology, 2018, 133(79-84.

[30] BERCHTOLD N C, CASTELLO N, COTMAN C W. Exercise and time-dependent benefits to learning and memory [J]. Neuroscience, 2010,167(3): 588-97.

[31] MAROSI K, FELSZEGHY K, MEHRA R D, et al. Are the neuroprotective effects of estradiol and physical exercise comparable during ageing in female rats? [J]. Biogerontology, 2012,13(4): 413-27.

[32] RADAK Z, TOLDY A, SZABO Z, et al. The effects of training and detraining on memory, neurotrophins and oxidative stress markers in rat brain [J]. Neurochemistry international, 2006, 49(4): 387-92.

[33] LUO L, LI C, DU X, et al. Effect of aerobic exercise on BDNF/proBDNF expression in the ischemic hippocampus and depression recovery of rats after stroke [J]. Behavioural brain research, 2019, 362(3)23-31.

[34] Aletta DK , Caroline G M, Floor Heesch,et al. The neuro-immune axis: prospect for novel treatments for mental disorders[J].Basic Clin Pharmacol Toxicol,2014,114(1):128-136.