Osteoporosis (OP) is a bone disease that seriously affects the health of the elderly. Due to the lack of awareness and prevention of OP in society, it is usually not discovered until fracture occurs. In recent years, the pathogenesis of OP has been gradually clarified. Many scholars have found that Chinese medicine has great potential in treating OP. Now, the treatment of OP with Chinese medicine has become a hot academic issue. This article mainly introduces several traditional Chinese medicines commonly used in the treatment of osteoporosis and their mechanism of action.

Youyu She, Ligang Fan, Wei Gao, Panpan Guo, Junxiu Xi, Hua Guo. Research Progress in the Treatment of Osteoporosis with Chinese Medicine. International Journal of Frontiers in Medicine (2023), Vol. 5, Issue 9: 80-86. https://doi.org/10.25236/IJFM.2023.050913.

[1] NIH Consensus Development Panel on Osteoporosis Prevention. Diagnosis and therapy. Osteoporosis, prevention, diagnosis, and therapy. JAMA 2001; 285: 785-95. 

[2] Coughlan T, Dockery F. Osteoporosis and fracture risk in older people. Clin Med (Lond), 2014, 14(2): 187-191. 

[3] Lynch MP, Capparelli C, Stein J L, et al. Apoptosis during bone-like tissue development in vitro[J]. J Cell biochem, 1998, 68(1): 31. 

[4] Zhuang Huafeng, Li Yizhong, Wang Peiwen, et al. Study of acute adverse drug reactions of zoledronic acid injection in the treatment of postmenopausal primary osteoporosis [J]. Chin J Clin Pharmacol, 2019, 35(11): 1119-1121, 1131. 

[5] Canalis E. Update in new anabolic therapies for osteoporosis. The Journal of Clinical Endocrinology and Metabolism, 2010, 95(4): 1496-1504. 

[6] Yan Hongmei, Zhang Zhenhai, Sun E, Song Jie, Jia Xiaobin, et al. Research progress on treatment of osteoporosis using Chinese material medica[J]. Chinese Traditional and Herbal Drugs, 2014, 45(8): 1174-1178. 

[7] Wei Hou, Bin Du, et al. Research progress of Traditional Chinese medicine in the treatment of osteoporosis [J] World Journal of Integrated Traditional and Westren Medicinenal. 2021, 16 (10): 1957. 

[8] Zhao Wenchang, Song Lijun, Wen Kaihang, et al. Research progress of Longspur Epimedium for anti-osteoporosis[J]. China Medical Herald, 2012, 9(25): 20-22. 

[9] Yu Wang, Wanru Dong, Xiaoxu Yang, et al. Research progress of active monomer of Epimedium in anti-osteoporosis [J]. Pharmacology and Clinic of Chinese Materia Medica, 2016, 32 (3): 197-201. (in Chinese). 

[10] Da Weiwei, Zhao Yongjian, Wang Yongjun, et al. Effects of Icariin on expressions of BMP-2 mRNA and Runx-2 mRNA in preosteoblastic cell lines OCT1 [J]. Shanghai Journal of Traditional Chinese Medicine, 2015, (5): 90-94. 

[11] Li Huizhen, Li Meng, Li Ruiyu, et al. Effects of epimedium on osteogenic differentiation of bone marrow mesenchymal stem cells [J]. Chinese Journal of Tissue Engineering Research, 2014, 18(6): 979-984. 

[12] Liu Haiyan, et al. Clinical Observation of Epimedii Herba in the Treatment of Osteoporosis [J]. Inner Mongolia Journal of Traditional Chinese Medicine, 2019. 38(1): 16-17

[13] Tu Yan, Xiong Lina, Liu Xiangjie, et al. Clinical effect of Herba Epimedii combed with Danxiankanggu capsule in the treatment of senile osteoporosis [J]. Anhui Medical and Pharmaceutical Journal, 2018, 22(9): 1814 -1817. 

[14] Wu Xinan, Zhao Yimin, et al. Isolation and indentification of chemical compounds from Drynaria fortunei [J]. China Journal of Chinese Materia Medica, 2005, 30 (6): 443-444. 

[15] Long M, Qiu D, Li F, et al. Flavonoid of Drynaria fortunei protectsagainst acute renal failure[J]. Phytother Res, 2005, 19 (5): 422-427. 

[16] Zhao Jinlong, Zeng Lingfeng, Liang Guihong, et al. Research progress on mechanism of active components of Chinese materia medica in treatment of osteoporosis based on signaling pathway[J]. Chinese Traditional and Herbal Drugs, 2020, 51(23): 6084-6094. 

[17] Wu Lianguo, Ni Ligang, Liu Kang, et al. Effects of Drynaria Total Flavonoids in Ovariectomized Rats aboutRANKL and E2 Concentration in Serum and BMC in Thighbone[J]. Chinese Archives Of Traditional Chinese Medicine, 2013, 31(12): 2628-2630. 

[18] Ang ES, Yang X, Chen H, et al. Naringin abrogates osteoclastogenesis and bone resorption via the inhibition of RANKL-induced NF-κB and ERK activation. FEB Lett, 2011, 585(17): 2755-62. 

[19] Shi Xiaolin, Li Chunwen, Sun Jinxu, et al. The effect of drynaria total flavonoids on expression of Cathepsin K in ovariectomized rats[J]. Chin J Osteoporosis & Bone Mine Rres, 2010, 3(4): 285-290. 

[20] Guo Ying, Li Peifang, Shu Xiaochun, et al. InvoIvement of Wnt/β-catenin signaling in the osteogenesis of bone marrow mesenchymal stem cells induced by drynaria total flavonoids[J]. Chinese Journal of Medicine, 2012, 92 (32): 2288-2291. 

[21] Zhang Chunqi, Liu Penghe. Treating 68 cases of osteoporosis in postmenopausal women with flavonoids of rhizome drynariae [J]. Clinical Research of Chinese Medicine, 2015, 7 (28): 103-104. 

[22] Pan Y, Niu Y, Li C, et al. Du-zhong (Eucommia ulmoides) prevents disuse-induced osteoporosis in hind limb suspension rats [J]. Am J Chin Med, 2014, 42(1): 143. 

[23] Yang Zhiyun, Lan Bo, Ling Ting, et al. Influence of Eucommia Extracts on MC3T3. E1 Subclone 14 Osteoblast [J]. Journal of Guizhou Medical University, 2017, 42 (5): 553-556. 

[24] Cao Xu, Xiang Wenying, Lu Yuan, et al. Effects of serum containing eucommia ulmoides on osteoblasts in vitro [J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2016, 31 ( 8 ): 3016-3019. 

[25] Wang Du, Dai Yi, Fan Yanbo, et al. Effects of Eucommia Ulmoides and Fructus Psoraleae on osteoblast proliferation and expression of MMP3 / OPN pathway proteins in ovariectomized rats [J]. Chin Hosp Pharm J, 2016, 36 (8): 620-624. 

[26] Chen Linpan, Deng Mingtao, Du Chuan, et al. A Study of Quercetin Extracted from Eucommia Leaf Promoting the Proliferation of Bone Marrow Derived Mesenchymal Stem Cells through the Phosphorylation of ERK [J]. Lishizhen Medicine And Materia Medica Research, 2014, 25(12) 2845-2847. 

[27] Yuan Chengfa, Yan Xiuzhong, Fang Jingwu, et al. Clinical study of Guzhong Bushen Jiangu Granule combined with warm acupuncture in treatment of kidney deficiency and essence deficiency type osteoporosis [J]. Henan Traditional Chinese Medicine, 2017, 37(11): 1981-1986. 

[28] Wang J, Chu X G. Quan Du Zhong capsule combined with Honghua Xiaoyao tablet for treatment of 38 cases of postmenopausal osteoporosis [J]. Chinese Journal of Gerontology, 2014, 34 (4): 1086-1087. 

[29] Wang Lili, MA Rufeng, YU Na, et al. Experimental study of salvianolic acid B on alveolar bone osteoporosis in mice with high fat diet through antioxidant effect [J]. Chinese Journal of Osteoporosis, 2017, 23 (3): 281-285; 317. 

[30] Zhang Xiao, Zhang Guoqing, Gu Bolin, et al. Effects of Salvia Miltiorrhiza on Production of Osteocalcin and Concentration of Calcium Ion in Human Osteoblasts. World Science and Technology /Modernization of Traditional Chinese Medicine and Materia Medica, 2013, 15(2): 274-278. 

[31] Fan Huanqiong, Cui Liao. Effects of salvianolic acid B on osteoblast in vitro. Chinese Pharmacological Bulletin, 2008, 24 (7): 978-979. 

[32] Nicolin V, Dal Piaz F, Nori S L, et al. Inhibition of bone resorption by Tanshinone VI isolated from Salvia miltiorrhiza Bunge. Eur J Histochem 2010, 54(2): 21. 

[33] Zhong Zuanyi, Chen Zhong, Huang Shuling, et al. A randomized parallel controlled study of Tanggukang Prescription combined with calcium carbonate D3 in the treatment of blood stasis type diabetes osteoporosis [J]. Journal of Practical Chinese Medicine Internal Medicine, 2017, 31 (7): 26-29. 

[34] Lin Gaotian. Study on biological effects of Astragalus Polysaccharide Cultured Mouse MC-3T3-E1 osteoblasts [D]. Changchun: Jilin University, 2016. 

[35] Kong Xianghe, Niu Yinbo, Wang Tingmei, et al. Effect of Astragalus polysaccharide on primary osteoblasts in rats and its mechanism [J]. Chinese Herbal Medicine, 2011, 42 (10): 2065. 

[36] Zhao XL, Chen JJ, Zhang GN, et al. Smallmolecule T63 suppresses osteoporosis by modulatingosteoblast differentiation via BMP and WNT signalingpathways [J]. Sci Rep, 2017, 7 (1): 10397. 

[37] Wu H. Experimental study on prevention and treatment of osteoporosis in ovariectomized rats with calycosin isoflavone [J]. Orthopedic Materials and Clinical Research, 2010, 7 (4): 11-14. 

[38] Qiu J. Clinical analysis of acupoint injection of Astragalus injection for osteoporosis [J]. Lin Med, 2013, 34 (24): 4952-4953. 

[39] Osteoporosis and Bone Mineral Salt Disease Branch, Chinese Medical Association. Guidelines for Diagnosis and treatment of primary osteoporosis (2011) [J]. Chinese Journal of Osteoporosis and bone mineral salt Diseases, 2011, 4 (1): 2-19.