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Academic Journal of Medicine & Health Sciences, 2023, 4(9); doi: 10.25236/AJMHS.2023.040902.

Research progress on the role of TGF-β in regulating the microenvironment of hepatocellular carcinoma and multidrug resistance


Ting Chen1, Xiaofeng Wang1, Yulei Gou1, Bingtao Zhai2, Xiaoyan Shi1,3, Cuijuan Li1,3, Dongyan Guo2, Yu Fan1,3

Corresponding Author:
Yu Fan

1The Basic Medical College, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China

2The Pharmacy College, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China 

3Shaanxi Key Laboratory of Research on TCM Physical Constitution and Disease Prevention and Treatment, Xianyang, Shaanxi, 712046, China


Liver cancer is one of the malignant tumors of the digestive system with high incidence. The specificity of early clinical manifestations is not significant, and it is often difficult to detect. Most patients are diagnosed in the middle and late stage, at which time chemotherapy is the preferred treatment, and multi-drug resistance of patients to chemotherapy drugs is the main obstacle to poor chemotherapy effect. The microenvironment of liver cancer is closely related to the formation of multi-drug resistance of liver cancer. TGF-β, as a key regulatory factor in the microenvironment of liver cancer, plays an important regulatory role in the development, invasion, and metastasis of liver cancer cells, blood vessel production and epithelial-mesenchymal transformation in the microenvironment of liver cancer. At the same time, the regulatory effect of TGF-β on tumor microenvironment is closely related to multi-drug resistance of liver cancer. Studying the role and mechanism of TGF-β in regulating liver cancer microenvironment and multi-drug resistance, and finding the target of reversing multi-drug resistance of chemotherapy drugs has become an urgent problem for liver cancer treatment.


liver cancer; Multidrug resistance; Tumor microenvironment; Liver cancer microenvironment; TGF - beta

Cite This Paper

Ting Chen, Xiaofeng Wang, Yulei Gou, Bingtao Zhai, Xiaoyan Shi, Cuijuan Li, Dongyan Guo, Yu Fan. Research progress on the role of TGF-β in regulating the microenvironment of hepatocellular carcinoma and multidrug resistance. Academic Journal of Medicine & Health Sciences (2023) Vol. 4, Issue 9: 7-14. https://doi.org/10.25236/AJMHS.2023.040902.


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