Polycystic ovary syndrome is a common gynecological endocrine disease, which is characterized by long-term anovulation and hyperandrogenemia. In recent years, western medicine treatment for polycystic ovary syndrome mostly adopts drug treatment methods, and its preferred drug is Diane-35 (ethinylestradiol cyproterone tablets). Although it can improve the clinical performance of patients, its recurrence is high, and there is a risk of adverse reactions after long-term medication. Traditional Chinese medicine believes that polycystic ovary syndrome belongs to gynecological "infertility", "amenorrhea", "irregular menstruation" and other categories, and puts forward specific dialectical treatment methods, of which the role of Diane-35 is more prominent. This article discusses the treatment of polycystic ovary syndrome by traditional Chinese medicine combined with Diane-35, and summarizes the strategy and research progress of Diane-35 combined with traditional Chinese medicine for polycystic ovary syndrome, so as to provide a certain reference for clinical treatment in the future.

Song Li, Gao Weihua. Research Progress of Diane-35 Combined with Traditional Chinese Medicine in the Treatment of Polycystic Ovary Syndrome. Academic Journal of Medicine & Health Sciences (2023) Vol. 4, Issue 9: 96-101. https://doi.org/10.25236/AJMHS.2023.040915.

[1] Ding Xiaonan, An Mingxia, Zhao Fanqin. Diagnosis and treatment of phlegm dampness type polycystic ovary syndrome from the perspective of "eliminating phlegm and resolving fat" [J] Journal of practical internal medicine of traditional Chinese medicine, 2023, 37 (07): 15-17. 

[2] Chen Jintang, Zhuang Liangwu, Lin Youguo. Observation of the follicle effective rate of integrated traditional Chinese and Western medicine in the treatment of early polycystic ovary syndrome of kidney deficiency and phlegm dampness type [J]. Clinical research of traditional Chinese medicine, 2020, 12 (20): 107-109. 

[3] Zhao Junli. Research progress in the etiology and diagnosis of polycystic ovary syndrome [J]. World clinical medicine, 2020, 41 (08): 587-593. 

[4] Guo Xiulian. Clinical observation of modified Yishi guntan pill combined with Diane-35 in the treatment of polycystic ovary syndrome infertility [J]. Guangming traditional Chinese medicine, 2018, 33 (18): 2741-2743. 

[5] Xie Deling, Jin Xun, Yao Lichan. Clinical effect of integrated traditional Chinese and Western medicine in the treatment of phlegm dampness obesity polycystic ovary syndrome [J] World Journal of traditional Chinese medicine, 2019, 14 (09): 2305-2308. 

[6] Mei Juli, Wang Jianxia. Clinical observation of Bushen Huoxue Decoction Combined with Diane-35 in the treatment of polycystic ovary syndrome of kidney deficiency and blood stasis type [J]. Sichuan Traditional Chinese medicine, 2015, 33 (12): 94-95. 

[7] Li Xiao, Zhang Yuhang, Zhou Yanyan. The protective effect of invigorating the spleen, removing dampness and tonifying the kidney on ovarian function in patients with non-obese polycystic ovary syndrome [J]. Journal of traditional Chinese medicine, 2019, 34 (09): 1977-1981. 

[8] Zhang Hongmei, Lei Lei. Observation on the effect of siwuhefang combined with Diane-35 in improving endometrial receptivity of polycystic ovary syndrome [J]. Hunan Journal of traditional Chinese medicine, 2020, 36 (05): 64-66. 

[9] Chen Caiyan, Xue Shanle. Danggui Shaoyao Powder Combined with Diane-35 in the treatment of polycystic ovary syndrome [J]. Clinical Journal of traditional Chinese medicine, 2018, 30 (08): 1511-1513. 

[10] He Wenjie, Zhao Rui. Efficacy of Guizhi Fuling combined with Diane-35 in the treatment of polycystic ovary syndrome infertility and its effect on serum visfatin and high-sensitivity C-reactive protein levels [J]. Guangxi Medical Journal, 2017, 39 (2): 165-168. 

[11] Xing Xingting, Xie Bo, Chen Xiaoping, et al. Clinical observation of Liqi Huatan Decoction in the treatment of hyperandrogenemia in polycystic ovary syndrome of phlegm and blood stasis type [J]. Journal of Guangzhou University of traditional Chinese medicine, 2023, 40 (6): 1388-1393. 

[12] Lu Lingyun, Shen Xiaoheng, Yuan Min. Clinical efficacy analysis of cangchai Tiaozhong decoction combined with Diane-35 in the treatment of phlegm dampness block polycystic ovary syndrome [J]. World Journal of integrated traditional Chinese and Western medicine, 2019, 14 (10): 1460-1463. 

[13] Cai Limei, Yu Rufen, Ding Xiangcui. Clinical observation of Zixian Zhuyun decoction combined with Diane-35 in the treatment of polycystic ovary syndrome infertility [J]. Chinese Journal of Traditional Medical Science and Technology, 2017, 24 (2): 203-205. 

[14] Liu Min, Cao Qi, Qian Qiaohong, et al. Clinical observation of effects of Baogui Capsules combined western medicine on anti-mullerian hormone level in patients with polycystic ovarian syndrome [J]. Shanghai Journal of traditional Chinese medicine, 2018, 52 (6): 40-43. 

[15] Yang Fan, Yang Lei, Yang Jianbing, et al Effect of cangfu Shenqu decoction combined with Diane-35 and Shenque point salt partitioned moxibustion on polycystic ovary syndrome infertility [J]. Liaoning Journal of traditional Chinese medicine, 2022, 49 (11): 127-130. 

[16] Yao Xin. Effect of daying-35 combined with Yishen Qutan Decoction on sex hormone levels and TCM syndrome scores in adolescent patients with polycystic ovary syndrome [J]. e-journal of practical gynecological endocrinology, 2022, 9 (05): 89-92. 

[17] Chen Xiaomei, Zou Yujun, Jiang Yan. Observation on the curative effect of traditional Chinese medicine Xiaofa combined with Diane-35 in the treatment of polycystic ovary syndrome [J]. Journal of modern integrated traditional Chinese and Western medicine, 2016, 25 (05): 501-503. 

[18] Liu Chunni, Liao Xinbo, Zhou Liyun. Clinical study on the treatment of polycystic ovary syndrome with four phase therapy of traditional Chinese medicine and Diane-35 [J]. Guangming traditional Chinese medicine, 2017, 32 (09): 1335-1338. 

[19] Li Yuchang, Zeng Lei, Li Yonghong, et al. Modified Dingjing decoction combined with Diane-35 in the treatment of polycystic ovary syndrome [J]. Journal of traditional Chinese medicine, 2018, 33 (11): 2235-2238. 

[20] Huang Ximei. Clinical observation of ovulation decoction combined with Diane-35 in the treatment of polycystic ovary syndrome [J]. Chinese folk therapy, 2018, 26 (12): 63-64. 

[21] Teng Jing, Yu Jun, Liao Hongyu. Clinical effect of Bushen Huoluo decoction combined with Diane-35 in the treatment of polycystic ovary syndrome with kidney deficiency and blood stasis syndrome [J]. World Journal of traditional Chinese medicine, 2017, 12 (12): 2942-2945. 

[22] Hua Zhongshou, Hou Zhiyan, Wang Hong, et al Clinical study of Tiaojingcuyun pill combined with Diane-35 in the treatment of obesity type polycystic ovary syndrome infertility [J]. China pharmaceutical, 2019, 28 (18): 38-40. 

[23] Chen Yingxia, Jin Hai’e, Li Xiuni. Yishen Huatan Tiaojing decoction combined with Diane-35 in the treatment of 60 cases of polycystic ovary syndrome [J]. China Science and technology of traditional Chinese medicine, 2019, 26 (03): 463-465. 

[24] Cao Lianghua. Effect evaluation of Diane-35 combined with Yougui Pill in the treatment of polycystic ovary syndrome [J]. Journal of practical Gynecological Endocrinology (Electronic Edition), 2018, 5 (13): 95-96. 

[25] Xin Jun, Guo Huimei, Gao Xihuan, et al. Cangfu Daotan decoction combined with Diane-35 in the treatment of polycystic ovary syndrome [J]. Journal of modern integrated traditional Chinese and Western medicine, 2017, 26 (02): 197-199. 

[26] Yuan Huifang, Hu Yajun. Clinical observation of Qilin pill combined with Diane-35 in the treatment of patients with polycystic ovary syndrome [J]. Journal of Hubei University for nationalities (Medical Edition), 2018, 35 (03): 37-40. 

[27] Zhang Meiling, Yu Cibi, Luo Xinmei. Study on the curative effect of ovulation promoting self-made formula and Diane-35 on polycystic ovary syndrome [J]. Clinical practice of integrated traditional Chinese and Western medicine, 2019, 19 (09): 83-85. 

[28] Wu Mingzhu. Effect analysis of Diane-35 combined with Kunling pill in the treatment of polycystic ovary syndrome [J]. Zhongwai medical, 2021, 40 (28): 78-81. 

[29] Wang Chunhuan. Effect of modified Zigui decoction combined with Diane-35 on patients with polycystic ovary syndrome of liver kidney yin deficiency type [J]. China Minkang medicine, 2020, 32 (24): 100-102. 

[30] Qian Zujuan. Efficacy of Diane-35 combined with Kuntai Capsule in the treatment of polycystic ovary syndrome [J]. E-journal of practical gynecological endocrinology, 2022, 9 (30): 85-88.