We conducted a systematic review and meta-analysis to acquire a reliable estimation of the prevalence and incidence of osteoporosis fracture in Chinese mainland and to characterize its epidemiology. We identified eligible studies with information on the prevalence or incidence of osteoporosis fracture in population-based observational studies and extracted data from published reports. We did random-effects meta-analysis to generate estimates. This study was preregistered in the INPLASY data-base (INPLASY202240112). Out of 3535 records identified, 33 studies with 1,970,135 participants were eligible for this study. The prevalence of osteoporosis fractures shows an interesting Kuznets curve (also known as inverted U curve) over time; In terms of incidence rate, the incidence of osteoporosis fracture obviously decreased over the past few decades. The prevalence and incidence of osteoporosis fracture was higher in females than in male and increased with age. Osteoporosis fracture prevalence was higher in urban than in rural areas and higher in southern than in northern areas. Osteoporosis fracture incidence was higher in rural than in urban areas and higher in southern than in northern areas.at present, the prevalence and incidence of osteoporosis fracture among the Chinese mainland was very high. Our study provides the prevalence (17.98% [95% CI, 13.12-23.41%]) and incidence (988 per 10,000 person-years [95% CI, 4.98%-16.22%]) of osteoporosis fracture in Chinese mainland. These findings can be used to better assess the China health burden of osteoporosis fracture.

Mengfei Wang, Rushun Zhao, Haodong Qi, Binfei Zhang, Ke Xu, Chao Lu, Yangquan Hao. Prevalence and Incidence of Osteoporosis Fracture in Population-based Studies in Chinese Mainland: A Meta-analysis and Systematic Review. Academic Journal of Medicine & Health Sciences (2023) Vol. 4, Issue 10: 9-20. https://doi.org/10.25236/AJMHS.2023.041002.

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