Blocking tumor cell invasion and metastasis is one of the important ways to treat tumors. In this paper, HeLa cells were cultured with different concentrations of quercetin to evaluate the therapeutic effect of quercetin on human cervical HaLa cells cultured in vitro. RT-PCR was used to detect the expression of adhesion molecules CD44v6 and E-cadherin in human cervical cancer HeLa cells after quercetin action. The data showed that quercetin acted on HeLa cells , and with the increase of drug concentration, the proliferation inhibition rate of HeLa cells increased with dose-dependently (P<0.01).RT-PCR showed that quercetin significantly inhibited the expression of CD44v6, and enhanced the expression of E-cadherin with dose-dependence, which may ultimately have the effect of anti-metastasis of cervical cancer.

Manshu Lei, Quan Zhou, Aihua Chen, Wenfei Zheng, Wei Li. Effect and Significance of Quercetin on the Expression of CD44v6 and E-cadherin in Hela Cells. International Journal of Frontiers in Medicine (2023), Vol. 5, Issue 10: 53-56. https://doi.org/10.25236/IJFM.2023.051009.

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