International Journal of Frontiers in Medicine, 2023, 5(10); doi: 10.25236/IJFM.2023.051007.
Qi Wang1, Xiao Han1, Liyaxing Xu2, Anping Han3, Yong Feng4, Hongbao Liu5
1Shaanxi University of Chinese Medicine, Xianyang, China
2Xi'an Medical University, Xi'an, China
3Hanzhong Railway Central Hospital, Hanzhong, China
4Xi 'an Electric Power Central Hospital, Xi'an, China
5The Second Hospital Affiliated to Air Force Medical University, Xi'an, China
Ferritinophagy is a selective autophagy of cell mediated by a specific cargo receptor NCOA4, which transports intracellular ferritin to lysosome-autophagy for degradation and releases free iron. Ferritinophagy is essential for the regulation of iron homeostasis. However, excessive activation of ferritinophagy can lead to intracellular iron overload ,generates Reactive Oxygen Species by the Fenton reaction of Haber-Weiss cycle, and promotes the occurrence of intracellular lipid peroxidation ,which induces cellular ferroptosis .Recently, the study of ferritinophagy has become an increasingly concerned field, and has been proved to play a crucial role in the pathological mechanisms of a variety of diseases .In this review , we will review the research progress of the role of ferritinophagy in related kidney diseases in order to provide reference for future clinical and scientific research.
ferritinophagy, NCOA4, ferroptosis, iron homeostasis, kidney disease
Qi Wang, Xiao Han, Liyaxing Xu, Anping Han, Yong Feng, Hongbao Liu. Research advances of ferritinophagy in renal diseases. International Journal of Frontiers in Medicine (2023), Vol. 5, Issue 10: 39-46. https://doi.org/10.25236/IJFM.2023.051007.
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