Welcome to Francis Academic Press

International Journal of Frontiers in Medicine, 2023, 5(10); doi: 10.25236/IJFM.2023.051014.

Research Progress of Signal Pathways Related to Severe Community Acquired Pneumonia and Complications

Author(s)

Cheng Luo1, Yuanhang Ye1, Jia Ke2

Corresponding Author:
Jia Ke
Affiliation(s)

1Clinical College of Traditional Chinese Medicine, Hubei University of Chinese Medicine, Wuhan, China

2Hubei Provincial Hospital of Traditional Chinese Medicine, Hubei Academy of Traditional Chinese Medicine, Affiliated Hospital of Hubei University of Traditional Chinese Medicine, Wuhan, China

Abstract

Severe Community acquired pneumonia is one of the common critical diseases in clinic. It has the characteristics of rapid progress, difficult treatment, high mortality and many complications. Studies have shown that the pathogenesis of Severe Community acquired pneumonia may be related to the transduction of cellular signal pathways. Combined with the latest research progress at home and abroad, this paper summarizes the role of severe pneumonia related signal pathways in the pathogenesis, in order to provide potential targets for the treatment of Severe Community acquired pneumonia and provide some scientific basis for the research and development of new drugs.

Keywords

Severe community acquired pneumonia, Pathway, Research progress

Cite This Paper

Cheng Luo, Yuanhang Ye, Jia Ke. Research Progress of Signal Pathways Related to Severe Community Acquired Pneumonia and Complications. International Journal of Frontiers in Medicine (2023), Vol. 5, Issue 10: 88-95. https://doi.org/10.25236/IJFM.2023.051014.

References

[1] Duan, T., Du Y, Xing, C., Wang, H. Y. & Wang, R. F., Toll-Like Receptor Signaling and Its Role in Cell-Mediated Immunity. FRONT IMMUNOL, 13 812774 (2022).

[2] Wu, Y. et al., Suppression of NLRP3 inflammasome by Platycodin D via the TLR4/MyD88/NF-kappaB pathway contributes to attenuation of lipopolysaccharide induced acute lung injury in rats. INT IMMUNOPHARMACOL, 96 107621 (2021).

[3] Wang Y, Li H, Shi Y, et al., miR-143-3p impacts on pulmonary inflammatory factors and cell apoptosis in mice with mycoplasmal pneumonia by regulating TLR4/MyD88/NF-kappaB pathway. Biosci Rep, 40 7 (2020)

[4] Barnabei, L., Laplantine, E., Mbongo, W., Rieux-Laucat, F. & Weil, R., NF-kappaB: At the Borders of Autoimmunity and Inflammation. Front Immunol, 12 716469 (2021).

[5] Mulero, M. C., Huxford, T. & Ghosh, G., NF-kappaB, IkappaB, and IKK: Integral Components of Immune System Signaling. ADV EXP MED BIOL, 1172 207 (2019).

[6] Hirano, T. et al., Immunological Mechanisms in Inflammation-Associated Colon Carcinogenesis. INT J MOL SCI, 21 (2020).

[7] Sun, Z., Suo, H., Li, H., Li, S., & Shi G., The mechanism of Ginsenoside Rg1 regulating TLR4/NF-κB signaling pathway against myocardial tissue injury in rats with severe pneumonia. Tianjin Pharmaceutical, 49 271 (2021).

[8] Zhang, C. et al., Qingwenzhike Prescription Alleviates Acute Lung Injury Induced by LPS via Inhibiting TLR4/NF-kB Pathway and NLRP3 Inflammasome Activation. FRONT PHARMACOL, 12 790072 (2021).

[9] Zhang, H. et al., Baicalin relieves Mycoplasma pneumoniae infection‑induced lung injury through regulating microRNA‑221 to inhibit the TLR4/NF‑kappaB signaling pathway. MOL MED REP, 24 (2021).

[10] Liu, J. X. et al., Protective effect of forsythoside B against lipopolysaccharide-induced acute lung injury by attenuating the TLR4/NF-kappaB pathway. INT IMMUNOPHARMACOL, 66 336 (2019).

[11] Liu, T. Y. et al., Polygonatum sibiricum polysaccharides prevent LPS-induced acute lung injury by inhibiting inflammation via the TLR4/Myd88/NF-kappaB pathway. EXP THER MED, 20 3733 (2020).

[12] Wang, H., Zhang, X. & Zhang Q., Effects of salidroside on lung tissue inflammation and NF-κB and p38 signals in rats with severe pneumonia. Journal of Microcirculation, 31 7 (2021).

[13] Wang, X. et al., Curcumin ameliorated ventilator-induced lung injury in rats. BIOMED PHARMACOTHER, 98 754 (2018).

[14] Hu, X., Li, J., Fu, M., Zhao, X. & Wang, W., The JAK/STAT signaling pathway: from bench to clinic. Signal Transduct Target Ther, 6 402 (2021).

[15] Talotta, R., The rationale for targeting the JAK/STAT pathway in scleroderma-associated  interstitial lung disease. IMMUNOTHERAPY-UK, 13 241 (2021).

[16] Hu, W., et al., Study on the mechanism of IGF-1R regulating JAK/STAT signaling pathway in sepsis rats. Journal of modern Laboratory Medicine, 37 6 (2022).

[17] Xue, H. & Li, M., Protective effect of pterostilbene on sepsis-induced acute lung injury in a rat  model via the JAK2/STAT3 pathway. Ann Transl Med, 8 1452 (2020).

[18] Wu, P., et al., Effect of Fraxin on expression of inflammatory cytokines and activation of related pathways in rats with severe pneumonia. Journal of Immunology, 36 292 (2020).

[19] Zhang, P., Zhang, Y., & Wang, R., The improvement effect and mechanism of Fraxin on Streptococcus pneumoniae pneumonia in young mice. Journal of Guangzhou University of Chinese Medicine, 39 892 (2022).

[20] Pinheiro, D. et al., Resveratrol decreases the expression of genes involved in inflammation through  transcriptional regulation. Free Radic Biol Med, 130 8 (2019).

[21] Shi, Q., Su, X., Yang, X. & Liu, B., To investigate the effect of curcumin on lipopolysaccharide-induced acute lung injury in mice based on JAK2/STAT3 signaling pathway. Emergency of Chinese Traditional medicine, 28 797 (2019).

[22] Zhang, X. et al., Advances on the Anti-Inflammatory Activity of Oleanolic Acid and Derivatives. Mini Rev Med Chem, 21 2020 (2021).

[23] Montero, P., Milara, J., Roger, I. & Cortijo, J., Role of JAK/STAT in Interstitial Lung Diseases; Molecular and Cellular Mechanisms. INT J MOL SCI, 22 (2021).

[24] Xin, P. et al., The role of JAK/STAT signaling pathway and its inhibitors in diseases. INT IMMUNOPHARMACOL, 80 106210 (2020).

[25] Revathidevi, S. & Munirajan, A. K., Akt in cancer: Mediator and more. SEMIN CANCER BIOL, 59 80 (2019).

[26] Xu, F., Na, L., Li, Y. & Chen, L., Retraction Note to: Roles of the PI3K/AKT/mTOR signalling pathways in neurodegenerative diseases and tumours. CELL BIOSCI, 11 157 (2021).

[27] Fattahi, S., Khalifehzadeh-Esfahani, Z., Mohammad-Rezaei, M., Mafi, S. & Jafarinia, M., PI3K/Akt/mTOR pathway: a potential target for anti-SARS-CoV-2 therapy. IMMUNOL RES, 70 269 (2022).

[28] Yang, Z. et al., Inhibition of the PI3K/AKT Signaling Pathway or Overexpression of Beclin1 Blocks Reinfection of Streptococcus pneumoniae After Infection of Influenza A Virus in Severe Community-Acquired Pneumonia. INFLAMMATION, 42 1741 (2019).

[29] Chen, H. et al., Capsaicin Protects Against Lipopolysaccharide-Induced Acute Lung Injury Through the HMGB1/NF-kappaB and PI3K/AKT/mTOR Pathways. J Inflamm Res, 14 5291 (2021).

[30] Wang, K. et al., Glycyrrhetinic acid alleviates acute lung injury by PI3K/AKT suppressing macrophagic Nlrp3 inflammasome activation. Biochem Biophys Res Commun, 532 555 (2020).

[31] Zhu, H. et al., Mechanism of protective effect of xuan-bai-cheng-qi decoction on LPS-induced acute lung injury based on an integrated network pharmacology and RNA-sequencing approach. Respir Res, 22 188 (2021).

[32] Sun, Y. L., Zhang, D. M., Hu, F. & Lu, D. M.,Effect of respiratory pseudofilamentous yeast colonization on severe bacterial ventilator-associated pneumonia and PI3K/Akt/NF-κB signaling pathway. Chinese Journal of Hospital Infection, 33 1006 (2023).

[33] Krishna, B. M. et al., Notch signaling in breast cancer: From pathway analysis to therapy. CANCER LETT, 461 123 (2019).

[34] Wei, J. et al., Effect of Qingfeitouxie Formula on Notch signaling pathway in mice with Mycoplasma pneumoniae pneumonia. Journal of Guangzhou University of Chinese Medicine, 37 915 (2020).

[35] Xu, J. Y., Chang, W., Sun, Q., Peng, F. & Yang, Y., Pulmonary midkine inhibition ameliorates sepsis induced lung injury. J TRANSL MED, 19 91 (2021).

[36] Yao, J. et al., [Corrigendum] Astragaloside IV attenuates hypoxia‑induced pulmonary vascular remodeling via the Notch signaling pathway. MOL MED REP, 25 (2022).

[37] Liczbinski, P., Michalowicz, J. & Bukowska, B., Molecular mechanism of curcumin action in signaling pathways: Review of the latest research. PHYTOTHER RES, 34 1992 (2020).

[38] Zhou, L. et al., Emodin inhibiting neutrophil elastase-induced epithelial-mesenchymal transition through Notch1 signalling in alveolar epithelial cells. J CELL MOL MED, 24 11998 (2020).

[39] Dong, G., Zhang, J. &Hou, W., Regulation of Notch1 and Jagged1 signaling pathways in rats with radiation pneumonia by compound Matrine injection. Chinese Journal of Traditional Chinese Medicine, 34 4278 (2019).

[40] Wang, X. Z. et al., The multifaceted mechanisms of Paeoniflorin in the treatment of tumors:  State-of-the-Art. Biomed Pharmacother, 149 112800 (2022).

[41] Hua, S., Liu, F. & Wang, M., Emodin Alleviates the Airway Inflammation of Cough Variant Asthma in Mice by Regulating the Notch Pathway. Med Sci Monit, 25 5621 (2019).

[42] Wang, Y. Y. et al., Notch1 induces Th1/Th2 imbalance in neonatal mice infected with Streptococcus pneumoniae. Journal of Army Medical University, 44 2138 (2022).

[43] Shuai, Z. Y. et al.,Mechanism of Notch signaling regulating autophagy in alveolar epithelial cells in Klebsiella pneumoniae infection. Journal of Clinical Laboratory Medicine 39 580 (2021).

[44] Lanks, C. W., Musani, A. I. & Hsia, D. W., Community-acquired Pneumonia and Hospital-acquired Pneumonia. Med Clin North Am, 103 487 (2019).

[45] Torres, A. et al., Challenges in severe community-acquired pneumonia: a point-of-view review. Intensive Care Med, 45 159 (2019).

[46] Meduri, G. U. et al., Low-dose methylprednisolone treatment in critically ill patients with severe community-acquired pneumonia. Intensive Care Med, 48 1009 (2022).

[47] Tang, Q., Chen, Q., Li, Y. & Wang, Z., Association between Glucocorticoids and Mortality in Patients with Severe Pneumonia: A Systematic Review and Meta-Analysis Based on Randomized Controlled Trials. Comput Math Methods Med, 2022 1191205 (2022).