Investigating the relationship between pathogenic bacteria and bone metabolism indicators in patients with osteomyelitis of the jaw, in order to aid in understanding the mechanisms of the disease and improving treatment strategies. We retrospectively analyzed the basic information and laboratory test results of 34 patients diagnosed with osteomyelitis of the jaw who were treated at the Department of Oral and Maxillofacial Surgery of the First Affiliated Hospital of Xinjiang Medical University from December 1, 2022 to May 1, 2023. Data was analyzed using SPSS27.0 software. Among the 34 patients, 6 were under 40 years old, 16 were 60 or older, and 12 were between 40 and 60 years old. There were 15 male and 19 female patients. The types of osteomyelitis of the jaw were pyogenic (50%), radiation-induced (23.5%), and drug-induced (26.5%). There were no statistically significant differences in age or gender between different types of osteomyelitis of the jaw and bone metabolism indicators. Additionally, there were no significant differences in oral normal flora and non-oral normal flora on bone metabolism indicators, as well as bacterial culture results. However, older age was associated with higher parathyroid hormone levels, which may play a role in inhibiting normal bone metabolism.

Shuai Xie, Zhitao Yao. The correlation between the main pathogenic bacteria and bone metabolism markers in mandibular osteomyelitis. International Journal of Frontiers in Medicine (2023), Vol. 5, Issue 10: 127-131. https://doi.org/10.25236/IJFM.2023.051020.

[1] Bronkhorst MA, Van Damme PA. Osteomyelitis of the Jaws. Ned Tijd- schr Tandheelkd, 2006, 111(6): 222-225. 

[2] Buch K, Thuesen ACB, Brøns C, et al. Chronic Non-bacterial Osteomyelitis: A Review. Calcif Tissue Int, 2019, 104(5):544-553. 

[3] Kim SM, Lee SK. Chronic non-bacterial osteomyelitis in the jaw. Korean Assoc Oral Maxillofac Surg, 2019 Apr; 45(2):68-75. 

[4] Kvolik Pavić A, Zubčić V. Osteomyelitis of the Jaw in COVID-19 Patients: A Rare Condition with a High Risk for Severe Complications. Front Surg, 2022, 9:867088. 

[5] Sacco R, Shah S, Leeson R, et al. Osteonecrosis and osteomyelitis of the jaw associated with tumour necrosis factor-alpha (TNF-α) inhibitors: a systematic review. Br J Oral Maxillofac Surg, 2020 Jan; 58(1):25-33. 

[6] Lucidarme Q, Lebrun D, Vernet-Garnier V, et al. Chronic Osteomyelitis of the Jaw: Pivotal Role of Microbiological Investigation and Multidisciplinary Management-A Case Report. Antibiotics (Basel), 2022, 11(5):568. 

[7] Coviello V, Stevens MR. Contemporary concepts in the pathogenesis of the dental infections complicating osteonecrosis of the jaws. Oral Dis, 2020 May; 26(4):730-737. 

[8] Ruggiero S L, Dodson T B, Aghaloo T, et al. American Association of Oral and Maxillofacial Surgeons’ Position Paper on Medication-Related Osteonecrosis of the Jaws—2022 Update. Journal of oral and maxillofacial surgery, 2022, 80(5): 920-943. 

[9] Moreno MA, Hanna GJ, Chau NG, et al. Advances in radiotherapy management of oral cavity cancers. Translational Research in Oral Oncology, 2018; 3: 1-12. 

[10] Rasmusson L, Abtahi J. Bisphosphonate associated osteonecrosis of the jaw: an update on pathophysiology, risk factors, and treatment. Int J Dent, 2014, 2014: 471035. 

[11] Shuster A, Reiser V, Trejo L, et al. Comparison of the histopathological characteristics of osteomyelitis, medication-related osteonecrosis of the jaw, and osteoradionecrosis. Int J Oral Maxillofac Surg, 2019 Jan; 48(1):17-22. 

[12] Komori T. What is the function of osteocalcin? Journal of Oral Biosciences, 2020, 3(62): 223-227. 

[13] Arce K, Assael L A, Weissman J L, et al. Imaging findings in bisphosphonate-related osteonecrosis of jaws. J Oral Maxillofac Surg, 2009, 67(5 Suppl): 75-84. 

[14] Vimalraj S. Alkaline phosphatase: Structure, expression and its function in bone mineralization. Gene, 2020, 754: 144855. 

[15] Chen T. Parathyroid hormone and its related peptides in bone metabolism. Biochem Pharmacol, 2021(192): 114-669. 

[16] Adami S, Viapiana O, Gatti D, et al. Relationship between serum parathyroid hormone, vitamin D sufficiency, age, and calcium intake. Bone (New York, N. Y.), 2008, 42(2): 267-270. 

[17] Robertsson C, Sävendahl L, Cardemil C. Primary chronic osteomyelitis of the jaw: Rapid improvement after hormonal suppression in a girl with precocious puberty. Bone Rep, 2021, 14:101089. 

[18] Watts GS, Youens-Clark K, Slepian MJ, et al. 16S rRNA gene sequencing on a benchtop sequencer: accuracy for identification of clinically important bacteria. J Appl Microbiol, (2017), 123(6):1584-1596.