Welcome to Francis Academic Press

Academic Journal of Agriculture & Life Sciences, 2023, 4(1); doi: 10.25236/AJALS.2023.040109.

Research Advances in Secondary Metabolites and Biological Activities of Mushroom Genus Fungi


Cao Jinfeng, Chen Xuhui, Liu Shiwei, Ding Jianhai

Corresponding Author:
Ding Jianhai

College of Chemistry and Chemical Engineering, Ningxia Normal University, Guyuan, 756000, Ningxia, China


Agaricus fungi are widely distributed in nature, their secondary metabolites with novel structures and significant biological activities, mainly including steroids, terpenoids, nitrogen compounds, sphingoids, aliphatic compounds and other structural types, some of them possessed anti-tumor, antibacterial, anti-neurolysin, anti-angiotensin-converting enzyme activities. The secondary metabolites and their biological activities of Agaricus fungi in recent 20 years were reviewed to provide theoretical basis for further research and new drug development.


Agaricus fungi; secondary metabolites; biological activity

Cite This Paper

Cao Jinfeng, Chen Xuhui, Liu Shiwei, Ding Jianhai. Research Advances in Secondary Metabolites and Biological Activities of Mushroom Genus Fungi. Academic Journal of Agriculture & Life Sciences (2023) Vol. 4 Issue 1: 62-66. https://doi.org/10.25236/AJALS.2023.040109.


[1] Petrova A, et al. GC-MS studies of the chemical composition of two inedible mushrooms of the genus Agaricus[J]. CHEM CENT J, 2007, 1(1): 33.

[2] Munkhgerel L, et al. Chemical and biological investigation of the Agaricus silvaticus Schaeff ex. Secr[J]. Mongolian Journal of Chemistry, 2011, 12: 92-97.

[3] Shin Y, et al. Chemical Constituents of Inonotus ohliquus[J]. Eurasian J. For. Res., 2001, 2: 27-30.

[4] Ueguchi Y, et al. Constituents of cultivated Agaricus blazei[J]. J Nat Med, 2011, 65(2): 307-312.

[5] Shimizu T, et al. Agarol, an ergosterol derivative from Agaricus blazei, induces caspase-independent apoptosis in human cancer cells[J]. Int J Oncol, 2016, 48(4): 1670-1678.

[6] Ragasa C Y, et al. Sterols and Lipids from Agaricus bisporus[J]. Int. J. Pharm. Clin. Res., 2016, 8(10): 1451-1453.

[7] Sun Y, et al. Sterols from Mytilidae show anti-aging and neuroprotective effects via anti-oxidative activity. Int J Mol Sci, 2014, 15(12):21660-21673.

[8] Misgiati M, Aty W,Sentot J R, et al. Ergosterol isolated from Agaricus blazei Murill N-hexane extracts as potential anticancer MCF-7 activity[J]. Pharmacogn J. 2021; 13(2): 418-426.

[9] Hirotani M, et al. Blazeispirane and protoblazeispirane derivatives from the cultured mycelia of the fungus Agaricus blazei[J]. Phytochemistry, 2002, 61(5): 589-595.

[10] Hirotani M, et al. Agariblazeispirols A and B, an unprecedented skeleton from the cultured mycelia of the fungus, Agaricus blazei[J]. Tetrahedron Letters, 2003, 44(43): 7975-7979.

[11] Hirotani M, et al. Agariblazeispirol C from the cultured mycelia of the fungus, Agaricus blazei, and the chemical conversion of blazeispirol A[J]. Tetrahedron, 2005, 61(1): 189-194.

[12] Itoh H, et al. Blazein of a new steroid isolated from Agaricus blazei Murrill (himematsutake) induces cell death and morphological change indicative of apoptotic chromatin condensation in human lung cancer LU99 and stomach cancer KATO III cells[J]. ONCOL REP, 2008, 20(6): 1359-1361.

[13] Wu J, et al. Chemical constituents of Agaricus gennadii[J]. CHEM NAT COMPD+, 2020, 56(4): 761-762.

[14] Zhao J Y, et al. Two new sesquiterpenes from cultures of the basidiomycete Agaricus arvensis[J]. J Asian Nat Prod Res, 2013, 15(3): 305-309.

[15] Kimura Y, et al. Isolation of an anti‐angiogenic substance from Agaricus blazei Murill: Its antitumor and antimetastatic actions[J]. Cancer Science, 2004, 95(9): 758-764.

[16] Kohno K, et al. Anti-inflammatory and immunomodulatory properties of 2-amino-3H-phenoxazin-3-one[J]. BIOL PHARM BULL, 2008, 31(10): 1938-1945.

[17] Tian Y, Gui W, Smith P B, et al. Isolation and Identification of Aryl Hydrocarbon Receptor Modulators in White Button Mushrooms (Agaricus bisporus) [J]. J Agric Food Chem, 2019, 67(33): 9286-9294.

[18] Janák K, Størmer F C, Koller G E. The content of agaritine in spores from Agaricus bisporus[J]. Food Chemistry, 2006, 99(3): 521-524.

[19]Jennemann R, et al. Novel glycoinositolphosphosphingolipids, basidiolipids, from Agaricus[J]. Eur J Biochem, 1999, 259(1‐2): 331-338.

[20] Berg A, et al. Agaridiol, a new 1‐arylpropane‐1, 2‐diol produced by Agaricus sp[J]. J BASIC MICROB, 1999, 39(3), 213-215.

[21] Chan P, et al. Protective effects of trilinolein extracted from Panax notoginseng against cardiovascular disease[J]. Acta Pharmacol Sin, 2002, 23(12):1157-1162.

[22]Sun Y, et al. Sterols from Mytilidae show anti-aging and neuroprotective effects via anti-oxidative activity[J]. Int J Mol Sci, 2014, 15(12):21660–21673.

[23] Waqas H M, Akbar M, Khalil T, et al. Identification of natural antifungal constituents from Agaricus bisporus (J. E. Lange) imbach[J]. Applied Ecology and Environmental Research, 2018, 16(6): 7937-7951.

[24] Pham N L,, et al. Effect-directed analysis and chemical identification of agonists of peroxisome proliferator-activated receptors in white button mushroom[J]. Food and Function, 2021, 12(1),133-134..

[25] Wang J H, et al. Anti-phytopathogenic-bacterial fatty acids from the mycelia of the edible mushroom Agaricus blazei[J]. Biosci Biotechnol Biochem, 2022, 86(10):1327-1332.

[26] Stadler M, et al. Novel analgesic triglycerides from cultures of Agaricus macrosporus and other basidiomycetes as selective inhibitors of neurolysin[J]. J ANTIBIOT, 2005, 58(12): 775-786.

[27] Barros L, et al. Optimization of the determination of tocopherols in Agaricus sp. edible mushrooms by a normal phase liquid chromatographic method[J]. Food Chemistry, 2008, 110(4): 1046-1050.

[28] Dong S, et al. Brefeldin A is an estrogenic, Erk1/2-activating component in the extract of Agaricus blazei mycelia[J]. J AGR FOOD CHEM, 2013, 61(1): 128-136.

[29] Hammann S, Vetter W. Method development for the determination of free and esterified sterols in button mushrooms (Agaricus bisporus) [J]. J AGR FOOD CHEM, 2016, 64(17): 3437-3444.