Welcome to Francis Academic Press

Academic Journal of Medicine & Health Sciences, 2023, 4(12); doi: 10.25236/AJMHS.2023.041212.

Advances in the Study of the Relationship between Mitochondrial Damage and Neurodegenerative Diseases


Wei Wenqing1, Du Kejun1, Yao Jinyu2, Liu Ying1

Corresponding Author:
Wei Wenqing

1Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China

2Hechuan District Center for Disease Control and Prevention, Chongqing, 401519, China


Mitochondria are essential organelles in almost all cells (except erythrocytes) and are required for key processes such as bioenergy production, biosynthesis of reactive oxygen species, control of calcium homeostasis and triggering of cell death. Disruption of any of these processes can severely affect cellular function, especially neuronal function. Both hereditary and sporadic neurodegenerative diseases are inevitably accompanied by dysfunction of one or more key mitochondrial processes such as fusion, fission, reactive oxygen species production and energy generation. Mitochondrial damage plays an important role in the development of the neurodegenerative diseases amyotrophic lateral sclerosis, Parkinson's disease and Alzheimer's disease. Therefore, this paper reviews the literature on mitochondrial injury and neurodegenerative diseases in recent years and provides an overview of them to provide a referable basis for subsequent clinical studies.


Mitochondrial damage; neurodegenerative disease; correlation; research progress

Cite This Paper

Wei Wenqing, Du Kejun, Yao Jinyu, Liu Ying. Advances in the Study of the Relationship between Mitochondrial Damage and Neurodegenerative Diseases. Academic Journal of Medicine & Health Sciences (2023) Vol. 4, Issue 12: 88-95. https://doi.org/10.25236/AJMHS.2023.041212.


[1] Mohammed Akbar, Musthafa Mohamed Essa, Ghazi Daradkeh, et al. Mitochondrial dysfunction and cell death in neurodegenerative diseases through nitroxidative stress [J]. Brain Research, 2016, 1637:34-55. 

[2] Kumar Vishal, Kundu Satyabrata, Singh Arti, et al. Understanding the role of histone deacetylase and their inhibitors in neurodegenerative disorders: Current targets and future perspective [J]. Current neuropharmacology, 2021, 20(1):158-178. 

[3] Guy M. McKhann, David S. Knopman, Howard Chertkow, et al. The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease [J]. Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2011, 7(3):263-269. 

[4] Sharma Chanchal, Kim Sehwan, Nam Youngpyo, et al. Mitochondrial Dysfunction as a Driver of Cognitive Impairment in Alzheimer’s Disease [J]. International Journal of Molecular Sciences, 2021, 22(9):4850-4850. 

[5] de la Cueva Macarena, Antequera Desiree, Ordoñez Gutierrez Lara, et al. Amyloid-β impairs mitochondrial dynamics and autophagy in Alzheimer’s disease experimental models [J]. Scientific Reports, 2022, 12(1):10092-10092. 

[6] Tillement L, Lecanu L, Papadopoulos V. Alzheimer's disease: effects of beta‐amyloid on mitochondria [J]. Mitochondrion. 2011, 11(1):13-21. 

[7] González Rodríguez Patricia, Zampese Enrico, Stout Kristen A., et al. Disruption of mitochondrial complex I induces progressive parkinsonism [J]. Nature, 2021, 599(7886):650-656. 

[8] Kimberley J. Billingsley, Ines A. Barbosa, Sara Bandrés-Ciga, et al. Mitochondria function associated genes contribute to Parkinson’s Disease risk and later age at onset [J]. NPJ Parkinson's Disease, 2019, 5(1):1-9. 

[9] Harbauer Angelika B, Hees J Tabitha, Wanderoy Simone, et al. Neuronal mitochondria transport Pink1 mRNA via synaptojanin 2 to support local mitophagy [J]. Neuron, 2022, 110(9):1516-1531.e9. 

[10] Norat Pedro, Soldozy Sauson, Sokolowski Jennifer D., et al. Mitochondrial dysfunction in neurological disorders: Exploring mitochondrial transplantation [J]. npj Regenerative Medicine, 2020, 5(1):22-22. 

[11] Liu Chunyue, Fu Zixing, Wu Shanshan, et al. Mitochondrial HSF1 triggers mitochondrial dysfunction and neurodegeneration in Huntington's disease [J]. EMBO molecular medicine, 2022, 14(7):e15851-e15851. 

[12] Sawant Neha, Morton Hallie, Kshirsagar Sudhir, et al. Mitochondrial Abnormalities and Synaptic Damage in Huntington's Disease: a Focus on Defective Mitophagy and Mitochondria-Targeted Therapeutics [J]. Molecular neurobiology, 2021, 58(12):1-28. 

[13] Caron Nicholas S, Banos Raul, Yanick Christopher, et al. Mutant huntingtin is cleared from the brain via active mechanisms in Huntington disease [J]. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020, 41(4):780-796. 

[14] Jauhari Abhishek, Baranov Sergei V, Suofu Yalikun, et al. Melatonin inhibits cytosolic mitochondrial DNA-induced neuroinflammatory signaling in accelerated aging and neurodegeneration [J]. The Journal of clinical investigation, 2021, 131(9):3124-3136. 

[15] Sasaki Shoichi, Iwata Makoto. Mitochondrial alterations in the spinal cord of patients with sporadic amyotrophic lateral sclerosis [J]. Journal of neuropathology and experimental neurology, 2007, 66(1):10-16. 

[16] Liu Wenchao, Liu Tao, Liu Zhihui et al. Detection the mutated protein aggregation and mitochondriai function in fibroblasts from amyotrophic lateral sclerosis patients with SOD1 gene mutations [J]. National Medical Journal of China, 2016, 96(25):1982-1986. 

[17] Delic Vedad, Kurien Crupa, Cruz Josean, et al. Discrete mitochondrial aberrations in the spinal cord of sporadic ALS patients [J]. Journal of neuroscience research, 2018, 96(8):1353-1366. 

[18] Kumar Manoj, Pathak Dhananjay, Kriplani Alka, et al. Nucleotide variations in mitochondrial DNA and supra-physiological ROS levels in cytogenetically normal cases of premature ovarian insufficiency [J]. Archives of gynecology and obstetrics, 2010, 282(6):695-705. 

[19] Baines Christopher P, Kaiser Robert A, Purcell Nicole H, et al. Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death [J]. Nature, 2005, 434(7033):658-662. 

[20] Yajuan Xiao, Chehade Karam, Jianxun Yi, et al. ROS-related mitochondrial dysfunction in skeletal muscle of an ALS mouse model during the disease progression [J]. Pharmacological Research, 2018, 138:25-36. 

[21] Yasuzaki Yukari, Yamada Yuma, Ishikawa Takuya, et al. Validation of Mitochondrial Gene Delivery in Liver and Skeletal Muscle via Hydrodynamic Injection Using an Artificial Mitochondrial Reporter DNA Vector [J]. Molecular pharmaceutics, 2015, 12(12):4311-4320.

[22] Yuma Yamada, Takuya Ishikawa, Hideyoshi Harashima, et al. Validation of the use of an artificial mitochondrial reporter DNA vector containing a Cytomegalovirus promoter for mitochondrial transgene expression [J]. Biomaterials, 2017, 136:56-66. 

[23] Chuah Jo-Ann, Matsugami Akimasa, Hayashi Fumiaki, et al. Self-Assembled Peptide-Based System for Mitochondrial-Targeted Gene Delivery: Functional and Structural Insights [J]. Biomacromolecules, 2016, 17(11):3547-3557.

[24] Bacman Sandra R, Kauppila Johanna H K, Pereira Claudia V, et al. MitoTALEN reduces mutant mtDNA load and restores tRNAAla levels in a mouse model of heteroplasmic mtDNA mutation [J]. Nature medicine, 2018, 24(11):1696-1700.

[25] Almeida Liliana M, Pinho Brígida R, Duchen Michael R, et al. The PERKs of mitochondria protection during stress: insights for PERK modulation in neurodegenerative and metabolic diseases [J]. Biological reviews of the Cambridge Philosophical Society, 2022, 97(5):1737-1748. 

[26] Jia Yujie, Meng Dan, Sun Menglu, et al. Clinical Observation of Sanjiao Acupuncture on Mild to Moderate Alzheimer's Disease: A Randomized Controlled Trial [J]. Liaoning Journal of Traditional Chinese Medicine, 2017, 44(9): 1911-1914. 

[27] Liu Ke, Miao Linqing, Jiang, et al. Clinical Research Situation and Analysis of Acupuncture Compared with Western Medicine in Improving Cognitive Impairment and Behavioral and Psychological Symptoms in Patients with Alzheimer’s Disease [J]. Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology, 2021, 23(6): 2105-2115. 

[28] Zhao Ying. Clinical study on the treatment of mild-to-moderate Alzheimer's disease by acupuncture in the Duchenne vein [D]. Harbin: Heilongjiang University of Traditional Chinese Medicine, 2021. 

[29] Sheng Gang, Guo Zhen. Acupuncture in Treating 38 Cases of Parkinson′s Disease [J]. Western Journal of Traditional Chinese Medicine, 2018, 31(10):108-110. 

[30] Meng Bin, Tian Jing. Clinical Observation of Tong Du Wen Yang Needling for Amyotrophic Lateral Sclerosis [J]. Shanghai Journal of Acupuncture and Moxibustion, 2017, 36(2): 134-137. 

[31] Guo Xiaocong, Yang Dianhui, Fan Yingkong. A case of Huntington's disease treated with acupuncture combined with traditional Chinese medicine by Prof Yang Dianhui [J]. Journal of Sichuan of Traditional Chinese Medicine, 2017, 35(6): 152-153.