Mitochondria are essential organelles in almost all cells (except erythrocytes) and are required for key processes such as bioenergy production, biosynthesis of reactive oxygen species, control of calcium homeostasis and triggering of cell death. Disruption of any of these processes can severely affect cellular function, especially neuronal function. Both hereditary and sporadic neurodegenerative diseases are inevitably accompanied by dysfunction of one or more key mitochondrial processes such as fusion, fission, reactive oxygen species production and energy generation. Mitochondrial damage plays an important role in the development of the neurodegenerative diseases amyotrophic lateral sclerosis, Parkinson's disease and Alzheimer's disease. Therefore, this paper reviews the literature on mitochondrial injury and neurodegenerative diseases in recent years and provides an overview of them to provide a referable basis for subsequent clinical studies.

Wei Wenqing, Du Kejun, Yao Jinyu, Liu Ying. Advances in the Study of the Relationship between Mitochondrial Damage and Neurodegenerative Diseases. Academic Journal of Medicine & Health Sciences (2023) Vol. 4, Issue 12: 88-95. https://doi.org/10.25236/AJMHS.2023.041212.

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