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Academic Journal of Medicine & Health Sciences, 2023, 4(12); doi: 10.25236/AJMHS.2023.041213.

Treatment of Ulcerative Colitis based on Cohosh-atractylodes

Author(s)

Wang Jue, Yan Shuguang, Zheng Wen

Corresponding Author:
Yan Shuguang
Affiliation(s)

Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China

Abstract

Ulcerative colitis (UC), also known as chronic nonspecific ulcerative colitis, is a chronic inflammatory bowel disease of unknown etiology. The disease is characterized by frequent diarrhea, tenesmus, crampy abdominal pain, mucus, pus, and bloody stools [1]. According to the existing statistics in China, the prevalence and incidence of ulcerative colitis are increasing year by year, and it has become a common and frequent disease in China, and the treatment methods of modern medicine are limited, and the combination of traditional Chinese and Western medicine in the treatment of ulcerative colitis will have better efficacy and development. In the theoretical system of traditional chinese medicine, ulcerative colitis also belongs to the category of spleen and stomach diseases. In the history of traditional chinese medicine, Li Dongyuan, a physician who created the "spleen and stomach theory" of traditional chinese medicine, has a unique theoretical system and prescription system for the treatment of spleen and stomach diseases. Li Dongyuan is a clinical master of traditional chinese medicine, known as one of the "Four Masters of Jin Yuan" and "Replenishing Soil". His works "On the Spleen and Stomach" and "On the Distinction of Internal and External Injuries" laid an important foundation for the development of the "Theory of the Spleen and Stomach". After researching these works, the author found that Li Dongyuan's prescription medicine is mostly cold and hot drugs, among which cohosh-atractylodes is one of Li Dongyuan's commonly used drug pairs. After clinical and modern research, this pair of drugs has a good therapeutic and regulatory effect on ulcerative colitis. However, in clinical practice, these two drugs have not been widely used, and further discussion and research are needed.

Keywords

Cohosh-Atractylodes; ulcerative colitis; LI Dongyuan; IL-6; IL-8

Cite This Paper

Wang Jue, Yan Shuguang, Zheng Wen. Treatment of Ulcerative Colitis based on Cohosh-atractylodes. Academic Journal of Medicine & Health Sciences (2023) Vol. 4, Issue 12: 96-102. https://doi.org/10.25236/AJMHS.2023.041213.

References

[1] Chen Haozhu. Practical internal science [M]. The fifteenth edition. Beijing: People's Health Publishing House, 2017, 210-215. 

[2] Li Gao. Treatise on the spleen and stomach [M]. Lu Zhaolin, the main school. Shenyang: Liaoning Science and Technology Press, 1997. 

[3] Liu Xiaolan, Zhang Yongzhong. Improvement of sortylovolatile oil in rats with ulcerative colitis [J]. Tianjin Medicine, 2020, 48:956-960. 

[4] Wang Weining, Zhang Xichun, Liu Li. Immunological investigation of the pathogenesis of active-stage ulcerative colitis [J]. Chinese Journal of Modern Medicine, 2003, 13:74-76+79. 

[5] Jia Bailing, Hou Xiaohua. The relationship between interleukin-16 and ulcerative colitis [J]. Journal of Gastroenterology and Hepatology, 2004, 13:220-221. 

[6] Sandborn William J, Su Chinyu, Panes Julian, et al. Tofacitinib as Induction and Maintenance Therapy for Ulcerative Colitis [J]. The New England journal of medicine, 2017, 377(5):496-497. 

[7] Magro Fernando, Rodrigues Andreia, Vieira Ana Isabel, et al. Review of the disease course among adult ulcerative colitis population-based longitudinal cohorts [J]. Inflammatory bowel diseases, 2012, 18(3):573-583. 

[8] Stakenborg Michelle, Verstockt Bram, Meroni Elisa, et al. Neutrophilic HGF-MET signaling exacerbates intestinal inflammation [J]. Journal of Crohn's & colitis, 2020, 14(12):1748-1758. 

[9] Sun Huijuan, Zhu Liu, Wang Xianbo. Advances in cohosh [J]. Chinese Journal of Basic Medicine of Traditional Chinese Medicine, 2021, 27 (05): 837-840.

[10] Lin Caizhi, Hu Naiqiang, Zhao Haiyan, Li Guixian. On the application of wind medicine in the treatment of ulcerative colitis [J]. Liaoning Journal of Traditional Chinese Medicine, 2018, 45 (05): 954-957. 

[11] Li Min, Zhang Wen, Sun Huiyi, Wang Baixin, Tang Yi, Zhu Li. Application of wind medicine in the treatment of ulcerative colitis [J]. Modern Traditional Chinese Medicine Clinical, 2022, 29 (04): 55-59.

[12] Liang Yu, Zhao Yuanhong. Progress in the efficacy and pharmacological effects of cohosh [J]. Henan Traditional Chinese Medicine, 2021, 41 (03): 474-477. 

[13] Liu Yinze, Mu Xue, Li Peilei, Wu Hengmei. Progress on chemical composition and modern pharmacological effects of cocosis [J]. Wild Plant Resources in China, 2023, 42 (05): 1-8. 

[14] Chen Liyi, Li Jiaxin, Li Jiaxin, Zhang Meiqing, Yao Tie, Ding Liqin, Qiu Feng, Zhang Deqin. Progress on chemical composition and pharmacological effects of cohosh [J]. Chinese herbal medicine, 2023, 54 (05): 1685-1704. 

[15] Zhu Jing, Zhong Lingyun, Gong Qianfeng, Liu Liping, Yu Huan, Chen Ruilin. Effects of different cohosh cannons on gastrointestinal function in animals with temper deficiency [J]. Chinese Journal of Experimental Medicine, 2015, 21 (21): 1-4. 

[16] Zhang Jianying, Liang Ling, Nie Jian, Wei Deyong, Zuo Ai. Experimental study on the antidiarrheal effect of cohosh [J]. Journal of Traditional Chinese Medicine, 2016, 44 (03): 21-23. 

[17] Liang Yu, Zhao Yuanhong. Progress in the efficacy and pharmacological effects of cohosh [J]. Henan Traditional Chinese Medicine, 2021, 41 (03): 474-477. 

[18] Zhuang Dan, Qin Jing, Wang Huiyang, Miao Wenjun, Lu Guangping. Progress in the components of atractylodes [J]. Bioprocessing process, 2021, 19 (03): 306-313. 

[19] Qin Congcong, Du Qinyuan, Zhang Yimin, Sun Meiling, Zhan Zhaodhuang, Wang Jiafeng. Progress on chemical composition and pharmacological effects of volatile oil [J]. Chinese patent medicine, 2023, 45 (06): 1944-1952. 

[20] Wang Qian. Progress in the pharmacological effects of chemical components [J]. Biochemicals, 2023, 9 (01): 158-162. 

[21] Yan Yu, Tianzhu Jia, Qian Cai, et al. Comparison of the anti-ulcer activity between the crude and bran-processed Atractylodes lancea in the rat model of gastric ulcer induced by acetic acid [J]. Journal of Ethnopharmacology, 2015, 160:211-218.

[22] Zhang Hong, Han Ting, Sun Lianna, et al. Regulative effects of essential oil from Atractylodes lancea on delayed gastric emptying in stress-induced rats [J]. Phytomedicine, 2008, 15(8):602-611. 

[23] Zhang Mingfa, Shen Yaqin. Progress in the pharmacological effects of ASsystem and its active components [J]. Drug Evaluation study, 2017, 40 (03): 411-419. 

[24] Lin Caizhi, Hu Naiqiang, Zhao Haiyan, et al. The application of wind medicine in the treatment of ulcerative colitis [J]. Liaoning Journal of Traditional Chinese Medicine, 2018, 45(5):954-957.

[25] Hao Minqi, Luo Rong, Wang Ruiqiong, et al. Effects of goshen pill on proteins and gene expression related to JNK / Beclin 1 / Bcl-2 signaling pathway in rats with spleen-kidney Yang deficiency ulcerative colitis [J]. Chinese Journal of Traditional Chinese Medicine Information, 2022, 29 (01): 65-72. 

[26] Zeng Simin, Lin Wuhong, Luo Pengji, Wei Jing, Liang Qi, Huang Guihua. Progress in TCM treatment of ulcerative colitis [J]. Liaoning Journal of Traditional Chinese Medicine, 2020, 47 (06): 209-212.