Welcome to Francis Academic Press

Academic Journal of Medicine & Health Sciences, 2024, 5(4); doi: 10.25236/AJMHS.2024.050410.

Effects of Aerobic Exercise on Sleep Disorder of Breast Cancer Patients: A Systemic Review


Youran Dai1, Jiahao Chen1, Yingying Fang1, Wenhui Yang1, Meilan Hu2, Fule He3

Corresponding Author:
Fule He

1The First Clinical of Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China

2Department of Prevention and Health Care, Affiliated Hangzhou First People's Hospital of Westlake University, Hangzhou, Zhejiang Province, China

3Zhejiang Chinese Medical Museum of Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China


In recent decades, the problem of sleep disorders in patients with breast cancer has not been well addressed. Aerobic exercise, regarded as a new non-drug treatment, is currently being widely studied. The purpose of this study is to determine the effect of aerobic exercise on postoperative sleep disorders in patients with breast cancer. Research shows that aerobic exercise can alleviate sleep problems by improving patients' moods and stimulating blood circulation. In addition, this essay also discusses the specific influence mechanism of aerobic exercise. This article concludes that aerobic exercise can promote metabolism, and blood circulation and stimulate the pituitary to secrete an exciting hormone dopamine. Using such treatment methods can achieve the purpose of improving sleep quality by alleviating pain, relieving mood, and improving immune function. However, whether the mechanism of aerobic exercise is related to other signal transduction pathways or hormones in the human body is still unknown, and the specific treatment scheme has not been determined, so further research is needed.


Aerobic exercise; Breast cancer; Sleep disorder

Cite This Paper

Youran Dai, Jiahao Chen, Yingying Fang, Wenhui Yang, Meilan Hu, Fule He. Effects of Aerobic Exercise on Sleep Disorder of Breast Cancer Patients: A Systemic Review. Academic Journal of Medicine & Health Sciences (2024), Vol. 5, Issue 4: 71-75. https://doi.org/10.25236/AJMHS.2024.050410.


[1] Sung, H., et al., Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin, 2021. 71(3): p. 209-249.

[2] Feng, Y., et al., Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis. Genes Dis, 2018. 5(2): p. 77-106.

[3] Miller, K.D., et al., Cancer treatment and survivorship statistics, 2022. CA Cancer J Clin, 2022. 72(5): p. 409-436.

[4] Colagiuri, B., et al., Prevalence and predictors of sleep difficulty in a national cohort of women with primary breast cancer three to four months postsurgery. J Pain Symptom Manage, 2011. 42(5): p. 710-20.

[5] Fox, R.S., et al., Sleep disturbance and cancer-related fatigue symptom cluster in breast cancer patients undergoing chemotherapy. Support Care Cancer, 2020. 28(2): p. 845-855.

[6] Lebel, S., et al., From normal response to clinical problem: definition and clinical features of fear of cancer recurrence. Support Care Cancer, 2016. 24(8): p. 3265-8.

[7] Hirshkowitz, M., et al., National Sleep Foundation's sleep time duration recommendations: methodology and results summary. Sleep Health, 2015. 1(1): p. 40-43.

[8] Li, Y., et al., Various interventions for cancer-related fatigue in patients with breast cancer: a systematic review and network meta-analysis. Front Oncol, 2024. 14: p. 1341927.

[9] Rogers, L.Q., et al., Inflammation and psychosocial factors mediate exercise effects on sleep quality in breast cancer survivors: pilot randomized controlled trial. Psychooncology, 2015. 24(3): p. 302-10.

[10] Sitjar, P.H.S., et al., Combined aerobic and strength exercise training on biological ageing in Singaporean breast cancer patients: protocol for the Breast Cancer Exercise Intervention (BREXINT) Pilot Study. Geroscience, 2024. 

[11] Barbosa, M.P.d.M.F., et al., Efficacy of supervised exercise on sleep of women who survived breast cancer: a systematic review with meta-analysis. Journal of Cancer Survivorship, 2024.

[12] Bernard, P., et al., Temporal relationships between sleep and physical activity among breast cancer patients with insomnia. Health Psychol, 2016. 35(12): p. 1307-1315.

[13] Chiu, H.Y., et al., Walking improves sleep in individuals with cancer: a meta-analysis of randomized, controlled trials. Oncol Nurs Forum, 2015. 42(2): p. E54-62.

[14] Courneya, K.S., et al., Effects of exercise dose and type on sleep quality in breast cancer patients receiving chemotherapy: a multicenter randomized trial. Breast Cancer Research and Treatment, 2014. 144(2): p. 361-369.

[15] Drozd, C., et al., A randomized trial to evaluate the effects of a supervised exercise program on insomnia in patients with non-metastatic breast cancer undergoing chemotherapy: design of the FATSOMCAN study. Bmc Cancer, 2023. 23(1).

[16] He, X., et al., Effects of a 16-week dance intervention on the symptom cluster of fatigue-sleep disturbance-depression and quality of life among patients with breast cancer undergoing adjuvant chemotherapy: A randomized controlled trial. Int J Nurs Stud, 2022. 133: p. 104317.

[17] Hyndman, L., Exercise Timing and Sleep Quality Response to an Exercise Intervention in Breast Cancer Survivors. Medicine and Science in Sports and Exercise, 2015. 47(5): p. 692-698.

[18] Kreutz, C., M.E. Schmidt, and K. Steindorf, Effects of physical and mind-body exercise on sleep problems during and after breast cancer treatment: a systematic review and meta-analysis. Breast Cancer Res Treat, 2019. 176(1): p. 1-15.

[19] Matthews, E.E., et al., Effects of Exercise on Sleep in Women with Breast Cancer: A Systematic Review. Sleep Med Clin, 2018. 13(3): p. 395-417.

[20] Nourizadeh, R., et al., A Comparison of the Effects of Self-Acupressure and Aerobic Exercises on Sleep Disorders of Breast Cancer Survivors: A Controlled Randomized Clinical Trial. Med Acupunct, 2022. 34(2): p. 131-136.

[21] Payne, J.K., et al., Effect of exercise on biomarkers, fatigue, sleep disturbances, and depressive symptoms in older women with breast cancer receiving hormonal therapy. Oncol Nurs Forum, 2008. 35(4): p. 635-42.

[22] Steindorf, K., et al., Effects of exercise on sleep problems in breast cancer patients receiving radiotherapy: a randomized clinical trial. Breast Cancer Res Treat, 2017. 162(3): p. 489-499.

[23] Wang, W.-L., et al., The effect of yoga on sleep quality and insomnia in women with sleep problems: a systematic review and meta-analysis. Bmc Psychiatry, 2020. 20(1).

[24] Riemann, D., et al., European guideline for the diagnosis and treatment of insomnia. J Sleep Res, 2017. 26(6): p. 675-700.

[25] Sateia, M.J., International Classification of Sleep Disorders-Third Edition. Chest, 2014. 146(5): p. 1387-1394.

[26] Cuifang Liu , D.W., Analysis on the relevant factors of insomnia after breast cancer radical operation. China Journal of Traditional Chinese Medicine and Pharmacy, 2021. 36(10):6188-6192.

[27] Palesh, O.G., et al., Prevalence, demographics, and psychological associations of sleep disruption in patients with cancer: University of Rochester Cancer Center-Community Clinical Oncology Program. J Clin Oncol, 2010. 28(2): p. 292-8.

[28] Efficace, F., et al., Quality of patient-reported outcome reporting across cancer randomized controlled trials according to the CONSORT patient-reported outcome extension: A pooled analysis of 557 trials. Cancer, 2015. 121(18): p. 3335-42.

[29] Henselmans, I., H.C. de Haes, and E.M. Smets, Enhancing patient participation in oncology consultations: a best evidence synthesis of patient-targeted interventions. Psychooncology, 2013. 22(5): p. 961-77.

[30] Cramer, H., et al., Yoga for improving health-related quality of life, mental health and cancer-related symptoms in women diagnosed with breast cancer. Cochrane Database Syst Rev, 2017. 1(1): p. Cd010802.

[31] Rock, C.L., et al., American Cancer Society nutrition and physical activity guideline for cancer survivors. CA Cancer J Clin, 2022. 72(3): p. 230-262.

[32] Zuraikat, F.M., et al., Sleep and Diet: Mounting Evidence of a Cyclical Relationship. Annu Rev Nutr, 2021. 41: p. 309-332.

[33] González-Santos, Á., et al., Nonlinear, Multicomponent Physical Exercise With Heart Rate Variability-Guided Prescription in Women With Breast Cancer During Treatment: Feasibility and Preliminary Results (ATOPE Study). Phys Ther, 2023. 103(9).