This study systematically evaluates the clinical efficacy of Kangfuxin Liquid and Oral Ulcer Powder in treating recurrent oral ulcers. The study utilized computer-based searches via databases such as China National Knowledge Infrastructure (CNKI), VIP, PubMed, EMBASE, Web of Science, and Wanfang, covering literature from January 2013 to January 2024. A meta-analysis was conducted using RevMan 5.4.1, considering the effective rate as the outcome measure, focusing on studies involving treatments that combined Kangfuxin Liquid with Oral Ulcer Capsule Powder to treat Recurrent Oral Ulcers. Six articles, incorporating 828 samples, were selected through the screening process. Analysis results indicate a statistically significant greater efficacy when Kangfuxin Liquid was combined with Oral Ulcer Powder, as compared to the sole use of Oral Ulcer Powder [OR=5.04, 95%CI (2.86, 8.86), P<0.00001]. However, due to potential publication bias in this study, these results should be interpreted with some caution.

Wenghong Leong, Kamhou Xu, Yanting Ip. Comparative Study on the Efficacy of Kangfuxin Liquid Combined with Oral Ulcer Powder of Recurrent Oral Ulcers: A Meta-analysis. Academic Journal of Medicine & Health Sciences (2024), Vol. 5, Issue 5: 1-6. https://doi.org/10.25236/AJMHS.2024.050501.

[1] Nie Sen. Clinical efficacy of Kangfuxin Liquid combined with Oriental Ulcer Powder in the treatment of recurrent aphthous ulcer [J]. Contemporary Medicine, 2020, 26(23): 91–93.

[2] Li Xiaoyan, Ge Guolan. Analysis of the efficacy of Kangfuxin Liquid combined with cimetidine in the treatment of recurrent oral ulcers [J]. Journal of Practical Traditional Chinese Medicine Internal Medicine, 2020, 34(9): 83–85.

[3] Wang Ling. Clinical effect of three drugs combined to treat oral ulcers[J]. Chinese Pharmacoeconomics, 2024, 19(2): 99–103.

[4] Yu Jiaoling, Na Jie. Observation on the clinical efficacy of Kangfuxin Liquid in the treatment of recurrent oral ulcers [J]. Chinese Modern Drug Application, 2021, 15(4): 139–142.

[5] Zhu Fandi, Zou Jiaxin, Zhu Yunge. The efficacy of Bingbo Powder combined with Montmorillonite Powder in the treatment of recurrent oral ulcers [J]. Modern Medicine and Health, 2023, 39(23): 4010-4012+4017.

[6] Liu Yanxia. Analysis of the efficacy of traditional Chinese medicine Ulcer Powder in the treatment of recurrent oral ulcers [J]. Huaihai Medicine, 2017, 35(5): 588–590.

[7] Hu Liang. Analysis of the clinical efficacy of Kangfuxin Liquid in the treatment of gastric ulcer and its effect on inflammatory factors, oxidative stress and gastric mucosal repair [J]. Modern Diagnosis and Treatment, 2023, 34(17): 2543- 2545+2556.

[8] Li Xiang, Shen Chen. Li Qiangou’s clinical experience in treating recurrent oral ulcers[J]. Global Chinese Medicine, 2024, 17(2): 269–272.

[9] Hou Mingyan. Observation on the effect of Kangfuxin Liquid combined with Oriental Ulcer Powder in the treatment of recurrent aphthous ulcer [J]. Journal of Bethune Military Medical College, 2013, 11(6): 556–557.

[10] Li Jiao. Clinical efficacy of Kangfuxin Liquid combined with Oriental Ulcer Powder in the treatment of recurrent aphthous ulcer [J]. Heilongjiang Medicine, 2018, 31(6): 1294–1296.

[11] Ma Jiangmin, Xu Lemeng, Zhang Peng. Clinical study of Kangfuxin Liquid as an adjuvant treatment for recurrent oral ulcers in the elderly [J]. Chinese Journal of Geriatric Stomatology, 2018, 16(3): 154–156.

[12] Nian Liyan. Clinical analysis of the combined use of Kangfuxin Liquid and Oral Ulcer Powder in the treatment of recurrent aphthous ulcers [J]. Chinese Modern Drug Application, 2021, 15(14): 10–12.

[13] Xie Chun, Dai Lin, Liu Jian. Clinical observation on the treatment of recurrent aphthous ulcer with Kangfuxin Liquid combined with Orchid Ulcer Powder [J]. Chinese Pharmacy, 2016, 27(8): 1101–1103.

[14] Huang Dongmei. How to treat and prevent recurrent oral ulcers[J]. Gansu Science and Technology News, Gansu Science and Technology News, 2024: 008.

[15] Zha Biqing, Zhou Yiran, Chen Jing, et al. Dynamic analysis of oral flora in patients with recurrent oral ulcers [J]. Modern Preventive Medicine, 2023, 50(12): 2289-2294+2304.

[16] Liu Shuyi, Zhang Fengwu, Wang Liping. Zhang Fengwu’s experience in treating oral ulcers based on “Yin Fire Theory” [J]. Chinese Medicine Herald, 2023, 29(5): 154–156.

[17] Chao Chun'e. Clinical study on the pathogenesis and treatment of recurrent oral ulcers [J]. Chinese Contemporary Medicine, 2010, 17(3): 16–17.

[18] Zhang Xuesong. Pathogenesis and treatment of recurrent oral ulcers[J]. Chinese and Foreign Medical Research, 2012, 10(32): 107–108.

[19] Wang Pengwei, Yang Fei, Cao Wenqiu. Research progress on the clinical application of Periplaneta americana extract Kangfuxin Liquid at home and abroad [J]. Today’s Pharmacy, 2023, 33(10): 784–788.

[20] Luo Shichao. Clinical study on the treatment of chronic hypertrophic pharyngitis using traditional Chinese medicine cautery method combined with Kangfuxin liquid gargle[D]. Guangxi University of Traditional Chinese Medicine, 2023.