International Journal of Frontiers in Medicine, 2024, 6(7); doi: 10.25236/IJFM.2024.060704.
Haipeng Ren
Department of Oncology, Weifang People's Hospital, Weifang, 261041, China
50 male SD rats, of which 5 were in the normal group and the remaining 45 were modeled and divided into a model group of 15, a drug control group of 15, and an FL118 group of 15. After successful modeling, rats in the normal group and model group were gavaged with distilled water for 4 weeks. Rats in the drug control group were gavaged with gastric acid solution, while rats in the FL118 group were gavaged with FL118 solution for 4 weeks. Enzyme linked immunosorbent assay (ELISA) was used to detect levels of motilin (MTL) and gastrin (GAS), while Western blotting was used to detect the protein expression of Bax, Bcl-2, and GSK3 β,β- catenin. Study whether FL118 via Wnt/ β- catenin pathway inhibit the invasive ability and metastasis of rat gastric cancer cells, promote apoptosis of gastric cancer cells, and thus exert anti-tumor effects.
FL118; Wnt/ β- Catenin pathway; Gastric cancer; Rats; Motilin (MTL); Gastrin (GAS); Bax; Bcl2
Haipeng Ren. The effect of FL118 via Wnt/β- catenin pathway on invasion and apoptosis of rat gastric cancer cells. International Journal of Frontiers in Medicine (2024), Vol. 6, Issue 7: 16-20. https://doi.org/10.25236/IJFM.2024.060704.
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