Endometriosis (EMS) is a common gynecological disease that affects the reproductive health and quality of life of millions of women worldwide. This study aims to explore the specific role of hormone imbalance in the pathogenesis of EMS, particularly the regulatory roles of estrogen and progesterone in endometrial tissue growth and inflammatory response. In terms of experimental methodology, a classical mouse endometriosis model was firstly established, in which endometrial tissues were transplanted into the abdominal cavity of mice by surgical methods to simulate the pathological state of human EMS. An environment of hormonal imbalance was artificially created by administering different doses of estrogen and progesterone. This step critically mimics the pathological changes that can result from hormonal imbalance. During the treatment period, blood and tissue samples were collected regularly to evaluate the CRP (C-reactive protein) level and the expression of related inflammatory factor (IF) by ELISA (Enzyme Linked Immunosorbent Assay) and immunohistochemistry, and the endothelial tissue hyperplasia was evaluated by microscopic observation and histological analysis to evaluate the proliferation of endothelial tissue. The data on the growth rate of endometriotic tissue showed a gradual decrease in the rate of tissue growth over time after the start of treatment. The gradual decrease from the initial 100% to about 10% indicates that the treatment has a significant inhibitory effect. By clarifying how hormones affect the development of EMS, it helps the medical community to design more targeted interventions to improve treatment outcomes and patients' quality of life, and also provides a scientific basis for developing more effective treatment strategies in the future.

Xinyu Qi, Xinyuan Qi. The Role of Hormone Imbalance in the Pathogenesis of Endometriosis. Academic Journal of Medicine & Health Sciences (2024), Vol. 5, Issue 7: 42-51. https://doi.org/10.25236/AJMHS.2024.050707.

[1] He Fangzi, Jiang Ganghui, Chen Qinyi, et al. Meta-analysis of moxibustion treatment for endometriosis [J]. Journal of Guangzhou University of Traditional Chinese Medicine, 2023, 40 (6): 1572-1580.

[2] Kang Wenwen, Han Hedong, Wang Zhaofeng, et al. One case of recurrent unilateral bloody pleural effusion related to endometriosis [J]. Chinese Journal of Tuberculosis and Respiratory Diseases, 2024, 47 (05): 460-463.

[3] Cao Gaijing, Lv Xiaohui, Wang Mengxin, et al. Progress in clinical staging of endometriosis [J]. Chinese Journal of Practical Gynecology and Obstetrics, 2023, 39 (7): 762-765.

[4] Desai S, Oswal S, Parikh R. Haemorrhagic ascites: An atypical presentation of endometriosis[J]. Journal of Clinical and Scientific Research, 2024, 13(2):144-146.

[5] Li M, Wang Y, Shao Y,et al. Effects of acupuncture and moxibustion on UHRF1 and DNMT1 in ectopic endometrium of rats with endometriosis[J]. Journal of Acupuncture and Tuina Science, 2024, 22(3):204-213.

[6] Ito V, Pascual M. Exploring women's chronic disease experiences: A mixed-methods analysis of endometriosis narratives[J]. Language and Health, 2024, 2(1):58-65.

[7] Iito S, Fujita D, Kogata Y,et al. A case of hepatic endometriosis with previous laparoscopic surgery[J]. Advances in Obstetrics and Gynecology, 2022, 74(3):351-359.

[8] Gerasimov A M, Malyshkina A I, Kuligina M V, et al. Incidence rate and structure of external genital endometriosis in hospital patients[J]. Gynecology, 2021, 23(2):184-189.

[9] Kojima N, Kiuchi T. A Case Report of Abdominal Wall Endometriosis In The Postoperative Scarring Area Of A Cesarean Section [J]. Journal of the Showa University Society, 2020, 80(6):586-591.

[10] Ceccaroni M, Ceccarello M, Raimondo I. Roviglione G. Clarizia R. Bruni F. Mautone D. Manzone M. Facci E. Rettore L. Rossini R. Bertocchi E. Barugola G. Ruffo G. Barra F. "A Space Odyssey" on Laparoscopic Segmental Rectosigmoid Resection for Deep Endometriosis: A Seventeen-year Retrospective Analysis of Outcomes and Postoperative Complications among 3050 Patients Treated in a Referral Center[J]. Journal of minimally invasive gynecology, 2023, 30(8):652-664.

[11] Liu Xinyu, Zhang Yanqin, Deng Mengqi, et al. Establishment of endometriosis fibrosis nude mice model using xenotransplantation of human endometrium [J]. Chinese Journal of Clinical Obstetrics and Gynecology, 2023, 24(4):397-400.

[12] Yu J, Berga S L, Zou E, Schrepf A D, Clauw D J, As-Sanie S, Taylor R N. Neurotrophins and Their Receptors, Novel Therapeutic Targets for Pelvic Pain in Endometriosis, Are Coordinately Regulated by IL-1β via the JNK Signaling Pathway[J]. American Journal of Pathology: Official Publication of the American Association of Pathologists, 2023, 193(8):1046-1058.

[13] Chuting Wu, Dong X Y, Xinrong Li, et al. Acupuncture for endometriosis-associated infertility: Study protocol for a randomized controlled trial: Acupuncture treatment for endometriosis related infertility: a randomized controlled trial study protocol [J]. World Journal of Acupuncture – Moxibustion, 2024, 34(2):156-162.

[14] Ramirez-Pavez T N, Machado-Linde F, Garcia-Penarrubia P, et al. Optimization of peritoneal fluid and leukocyte collection in patients with endometriosis [J]. Fertility and Sterility: Official Journal of the American Fertility Society, Pacific Coast Fertility Society, and the Canadian Fertility and Andrology Society, 2023, 120(4):917-919.

[15] Higeta D, Kitahara Y, Tanaka, AyukoMorita, AkihitoSato, TatsuyaInoue, MakiSoda, MasayukiIwase, Akira. Cervical angle as a possible predictor of abnormal placental position in women with endometriosis [J]. The journal of obstetrics and gynaecology research, 2024, 50(4):580-586.