Autoimmune diseases (AIDs) are chronic systemic diseases of unknown etiology that predispose to widespread damage to multiple organs and systems. However, their exact pathogenesis is unclear and clinical treatment is difficult. In recent years, intestinal flora and immune regulatory mechanisms have become a research hotspot. Current studies have shown that intestinal flora plays a significant role in maintaining the immune and metabolic homeostasis of the body. With the increasing maturity of metabolomics and immunomics technologies, studies on the effects of traditional Chinese medicine (TCM) on intestinal flora have shown that TCM can play a positive role in the treatment of autoimmune diseases through the regulation of intestinal flora. This article reviewed the research progress of Chinese medicine regulating intestinal flora in the treatment of autoimmune diseases, and explored the mechanism of intestinal flora involved in immunomodulation in the treatment of diseases, and categorized and summarized the mechanism of immunomodulation between diseases and prescription medicines, which provided a new perspective for the exploration of the mechanism of Chinese medicine in the treatment of autoimmune diseases, with a view to providing a new direction and a new way of thinking for the treatment of autoimmune diseases.

Cao Ruotong, Zhao Weihan, Shen Jialin, Xi Chunhua. Research progress of Chinese medicine regulating intestinal flora in the treatment of autoimmune diseases. International Journal of Frontiers in Medicine (2024), Vol. 6, Issue 7: 64-71. https://doi.org/10.25236/IJFM.2024.060711.

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