This study aimed to use Mendelian randomization (MR) to investigate the potential causal relationship between sarcopenia and cognitive performance.31 independent single nucleotide polymorphisms (SNPs) were identified as instrumental variables of sarcopenia. Inverse variance weighted MR analysis revealed a significant negative association between genetically predicted sarcopenia and cognitive performance (β=-0.040, 95% CI: -0.070 to -0.010, p<0.01). However, MR-Egger regression did not support a causal effect. Mendelian randomization analysis results showed a weak causal relationship between sarcopenia and cognitive performance.

Yufan Pu. Deciphering the Genetic Link: The Influence of Sarcopenia on Cognitive Performance through Mendelian Randomization. Academic Journal of Medicine & Health Sciences (2024), Vol. 5, Issue 9: 25-30. https://doi.org/10.25236/AJMHS.2024.050905.

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