Platelets play a crucial role in thrombus formation and hemostasis. Using large public databases such as TCGA, this study analyzed the expression level of GPIb-alpha in diseases and healthy controls. The results showed that compared with normal tissues, the expression level of GPIb-alpha in the disease group was significantly reduced. In addition, patients with high expression of GPIb-alpha had a shorter survival time. There was a significant correlation between the expression of GPIb-alpha and CD8+ T cells (immune infiltration) in most diseases. String analysis revealed interactions between GPIb-alpha and various molecules such as 14-3-3zeta, GPV, and Integrin, among which 14-3-3zeta may be a potential regulatory molecule for thrombosis and hemostasis. In conclusion, the data indicate that the level of GPIb-alpha in disease tissue is lower than  that of control, and it may serve as a potential biomarker in diagnosis and prognosis of numerous diseases especially cancers.

Xie Yuhan. Expression of platelet membrane glycoprotein receptor GPIb-alpha in diseases and its prognostic value. Academic Journal of Medicine & Health Sciences (2024), Vol. 5, Issue 10: 1-7. https://doi.org/10.25236/AJMHS.2024.051001.

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