This article reviews recent research advances regarding the impact of the Mitochondrial Calcium Uniporter (MCU) on myocardial mitochondrial calcium metabolism during exercise, aiming to explore the crucial role of MCU in regulating calcium homeostasis in cardiomyocytes and protecting the myocardium from exercise-induced injury. Through a systematic review and analysis of relevant literature, we summarize the structure and function of MCU, its expression changes during exercise preconditioning and high-intensity exercise, as well as its regulatory mechanisms on myocardial mitochondrial calcium metabolism. Our analysis reveals that MCU exerts a significant influence on myocardial mitochondrial calcium metabolism during exercise, maintaining mitochondrial calcium homeostasis through the regulation of calcium ion transport and thereby protecting the myocardium from damage. Future research should delve deeper into the regulatory mechanisms of MCU and its specific roles in cardiovascular diseases, providing novel targets and strategies for exercise-based cardiac protection and cardiovascular disease treatment.

Hainiu Wang. Research Progress on the Impact of MCU on Myocardial Mitochondrial Calcium Metabolism during Exercise. Academic Journal of Medicine & Health Sciences (2024), Vol. 5, Issue 10: 27-32. https://doi.org/10.25236/AJMHS.2024.051005.

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