To verify the effect of Tongdu acupuncture combined with Huafeng Dan based on the theory of "warming yang and relieving depression" on depression scores and 5-HT and HCY in PSD patients. We selected 289 patients clinically diagnosed with post-stroke depression for our study and randomly divided them into two groups. The control group received routine treatment from the Department of Brain Diseases, while the experimental group received a combination of Tongdu acupuncture and Huafeng Dan on top of the control group. The Hamilton Depression Rating Scale (HAMD), Neurological Impairment Scale (NIHSS), and Activities of Daily Living (ADL) scores were measured before and after the intervention to verify its clinical efficacy by measuring 5-HT and HCY levels. The research results show that 952 patients were included in this study, and 289 patients with post-stroke depression were judged by Hamilton Depression Scale, with a incidence rate of 30.36%. ② The comparison of HAMD, NIHSS, and ADL scores between two groups of patients before and after intervention showed that the HAMD and NIHSS scores of both groups were lower than before intervention, while the ADL scores were higher than before intervention, with P<0.05, indicating statistical significance. After intervention, the experimental group was significantly better than the control group, with P<0.01, indicating significant statistical significance After intervention, 5-HT levels in both groups of patients increased compared to before intervention, while HCY levels were lower than before intervention. The inter group comparison showed that the experimental group was superior to the control group, with P<0.01 and significant statistical significance. The study suggests that adding the Tongdu acupuncture method based on the theory of "warming yang and relieving depression" combined with Huafeng Dan to PSD patients on the basis of conventional treatment can effectively alleviate depression, reduce neurological deficits, and improve patients' daily living abilities. It is worthy of clinical promotion and application.

Fei Wang, Huikai Wang. The theory of "warming yang and relieving depression" in improving depression scores of post-stroke depression patients and its impact. International Journal of Frontiers in Medicine (2024), Vol. 6, Issue 9: 55-61. https://doi.org/10.25236/IJFM.2024.060908.

[1] Liu Yan, Ba chi, Zhao Deng, et al. Resting state functional magnetic resonance imaging observation of the therapeutic effect of music therapy based on scalp acupuncture on post-stroke depression [J]. Chinese Journal of Rehabilitation Theory and Practice, 2021, 27 (03): 282-289.

[2] Zhang Huili, Wang Wengang, Zhao Xin, et al. Clinical study on the treatment of depression after ischemic stroke with Ning Shen Kai Qiao acupuncture method [J]. Hebei Journal of Traditional Chinese Medicine, 2021, 36 (02): 34-36.

[3] Tian Ming, Zheng Dan. Study on the Clinical Efficacy, SAS and HAMD Scale Scores, and 5-HT Levels of Post Stroke Depression Patients Using the Awakening Spirit and Opening Depression Acupuncture Method [J]. Journal of Stroke and Neurological Disorders, 2021, 38 (06): 518-521.

[4] Liu Fan. Correlation analysis between changes in serum homocysteine levels and depression in post-stroke depression patients [J]. Grassroots Medicine Forum, 2021, 25 (25): 3699-3700.

[5] Liu Honghua, Tu Li, Li Qian, et al. Application study of traditional Chinese medicine five tone therapy combined with acupoint pointer differentiation in post-stroke depression patients [J]. General Nursing, 2021, 19 (24): 3398-3401.

[6] Liu Jie. The effect of low-frequency repetitive transcranial magnetic stimulation combined with rehabilitation training on the levels of 5-HIAA and 5-HT in post-stroke depression patients [J]. Clinical Research, 2021, 29 (07): 92-94.

[7] Wang Xiaona, Wang Xiang, Miao Lili, et al. Study on the efficacy and mechanism of repetitive transcranial magnetic stimulation combined with music therapy in the treatment of post-stroke depression [J]. Neuro Injury and Functional Reconstruction, 2021,16 (08): 459-461.

[8] Yang Bende, Wang Heng, Xu Shengjun, et al. Clinical study of herbal separated moxibustion combined with emotional intervention in the treatment of post-stroke depression [J]. Shanghai Journal of acupuncture and moxibustion and Moxibustion, 2021,40 (08): 920-925.

[9] Lu Yi, Li Haihua, Yu Jianwei, et al. Study on the relationship between post-stroke depression and post-stroke cognitive impairment [J]. Modern Medicine and Health, 2021, 37 (15): 2577-2579+2585.

[10] Liu Li, Ding Yi, Wang Jian, etc Clinical efficacy of the "Five Tones Regulating Spirit Method" in treating post-stroke depression patients with mild to moderate liver depression and spleen deficiency, and its effects on gut microbiota and serum serotonin levels [J]. Chinese Journal of General Practice, 2021, 24 (30): 3882-3887.

[11] Chen Min, Ding Yuan, Huang Ying. Observation on the efficacy and quality of life of repeated transcranial stimulation therapy combined with psychological nursing intervention in patients with post-stroke depression [J]. Psychological Monthly, 2021,16 (18): 55-56.

[12] Zhang Shaohua, Wang Yulong, Zhang Chunxia, et al. Clinical study on interactive head therapy for cognitive function, depression, and anxiety after stroke [J]. Journal of Beijing University of Traditional Chinese Medicine, 2021, 44 (07): 659-667.

[13] Guo Yingshu, Liu Hongliang, Liu Jie. The clinical effect of the combination of "Shugan Tiaoshen" acupuncture method and Chaihu Shugan San in the treatment of post-stroke depression with liver qi stagnation type [J]. Henan Medical Research, 2021, 30 (20): 3659-3663.

[14] Li Yanli, Yang Zufu, Xu Jimin, et al. Acupuncture combined with flupentixide and metoprolol in the treatment of moderate depression after stroke: a randomized controlled study [J]. Chinese Journal of Rehabilitation Medicine, 2021, 36 (07): 810-815.