To investigate the peripheral blood cell count levels, especially the level of monocytes (MON), and the association with dyslipidemia in patients with chronic schizophrenia (CSCZ) and its clinical significance, a total of 150 patients with CSCZ who were long-term hospitalized, were selected and included in the disease group, and 100 healthy individuals selected in the control group. The differences in the levels of various peripheral blood cell counts indicators and lipid metabolism indicators between the two groups were compared. The relationships between 14 significant changes in peripheral blood cell counts indicators and CSCZ with dyslipidemia were explored using univariate and multivariate binary logistic regression analysis. The correlation between MON level and lipid indicators was also analyzed. There were significant differences in 14 peripheral blood cell counts indicators between CSCZ patients and healthy controls, with LYM% and RBC being significantly lower in the CSCZ, and WBC, MCV, RDW-SD, RDW-CV, PLT, PDW, MPV, PCT, MON#, and MON% being significantly higher. The levels of HDL-C, LDL-C, and CHO in CSCZ were lower than healthy controls significantly, while TG level was not statistically significant. The univariate binary logistic regression analysis showed that gender, HCT, HGB, MON#, and RBC were significantly associated with the risk of dyslipidemia in CSCZ. The multivariate analysis showed that an increase in MON# was significantly associated with the occurrence of dyslipidemia. Moreover, MON level was negatively correlated with HDL-C concentration and positively correlated with TG concentration. In conclusion, the levels of peripheral blood counts and lipid metabolism of CSCZ patients were significantly different from healthy controls. HCT, HGB, MON, and RBC may play an important role in the pathogenesis of CSCZ, and the level of MON may be related to dyslipidemia in CSCZ. The detection of MON level is important for the auxiliary diagnosis of CSCZ.

Luhua Chen, Weichao Su, Xinquan Xie, Haiying Lin, Fagen Zheng, Jiaqiang Zeng, Jindong Chen, Xiaopeng Deng. Association analysis of peripheral blood monocyte level and dyslipidemia in patients with chronic schizophrenia. International Journal of Frontiers in Medicine (2024), Vol. 6, Issue 10: 12-18. https://doi.org/10.25236/IJFM.2024.061002.

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