The theory of "brain-heart-kidney-bone" axis suggests that brain, heart, kidney and bone are physiologically interlocked, with blood and essence as the communication, Shenming as the leader and Dugong vein as the link, which together nourish bones and joints; pathologically, brain-centre imbalance, heart-kidney failure, brain-kidney disorders together lead to limb impotence and dysfunction mainly. This paper combines the complex pathophysiological symptoms of degenerative joint lesions in the elderly, based on the theory of "kidney is the master of bone" and the theory of "brain-heart-kidney-bone" axis, to sort out the physiopathology, aetiology and mechanism of the disease, identification and typing, and treatment, and to seek a better diagnosis and treatment of degenerative knee osteoarthritis in the elderly. We will seek more ideas and methods for the diagnosis and treatment of degenerative knee osteoarthritis in the elderly.

Xinxin Yang, Yan Wang, Anjun Wang, Kaiwei Zhang. Exploring the Pathogenesis and Therapeutic Approaches of Degenerative Joint Diseases Based on the Relationship between "Kidney Marrow" and the "Brain-Heart-Kidney-Bone" Axis. Academic Journal of Medicine & Health Sciences (2024), Vol. 5, Issue 11: 49-55. https://doi.org/10.25236/AJMHS.2024.051107.

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