This study aimed to explore the relationship between blood lipid levels and cognitive performance in older adults. The information was extracted from the American National Health and Nutrition Examination Survey (2011-2014), encompassing data on blood total cholesterol (TC), high density lipoprotein (HDL-C), cognitive performance, and 11 covariates (including age, gender, race, etc.). Logistics regression analysis shows that when all covariables are corrected, compared with HDL-C of the lowest third array, The OR values and 95%CI of the highest third array are 1.587( 1.236-2.039), 1.533(1.195-1.966) and 1.774(1.393-2.258), respectively. When no covariates are corrected, the OR value and 95%CI of the highest When no covariates are corrected, the OR value and 95%CI of the highest tripartite array are 1.587(1.236-2.039), 1.444(1.124-1.855) and 1.774(1.393-2.258), respectively, compared with the TC of the lowest tripartite array. No correlation was found between TC and cognitive ability. There was no statistical significance between the TC:HDL-C ratio and the CERAD test, but in the AF test, compared with the TC of the lowest tripartite. There was no statistical significance between the TC:HDL-C ratio and the CERAD test, but in the AF test, compared with the TC:HDL-C ratio of the lowest third array, The OR values and 95%CI of the middle third array are 0.766(0.599- 0.981), 0.723(0.563-0.929) and 0.750(0.572-0.982) respectively in the three models, and the correlation is not strong in the DSST test. Conclusion HDL-C level was positively correlated with the TC:HDL-C ratio of the lowest third array. TC was positively correlated with cognitive ability in the elderly, and TC: HDL-C ratio was negatively correlated with cognitive level in the elderly. The conclusions of this study need to be validated by further prospective cohort studies.

Zeke Chen, Hua Ning, Jialiang Yang, Zihao Wang, Shumin Li, Yanyan Wang. Association of blood lipid level with cognitive performance in older adults: A cross-sectional study based on NHANES. Academic Journal of Medicine & Health Sciences (2024), Vol. 5, Issue 12: 14-20. https://doi.org/10.25236/AJMHS.2024.051203.

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