The innate immune system in the body can defend against viral infections through a variety of mechanisms, and autophagy has recently been found to be effective in defending against viral particles that infect cells. Viral infection can promote autophagy through pattern recognition receptors, which are located in the cell membrane and cytoplasm and are initiators of the cell's natural immune responses. Autophagy regulates the natural antiviral response mediated by pattern recognition receptors and plays an important role in maintaining immune homeostasis. However, some viruses have evolved to establish the ability to evade autophagy or to use autophagy to evade antiviral immune responses. The mutual regulation between viruses, autophagy and natural immune responses against viral infections is a hot area of research. The aim of this paper is to provide an overview of recent advances in this field and to raise important questions to be solved for relevant researchers.

Zhanying Hu, Qinglu Zhao, Dingcheng Wei, Ruizhe Li, Rui Zhang. Inter-regulation between Autophagy and Innate Immunity in Antiviral Responses. International Journal of Frontiers in Medicine (2024), Vol. 6, Issue 12: 22-28. https://doi.org/10.25236/IJFM.2024.061204.

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