This study uses bibliometric analysis to systematically examine the status and trends of nanoparticle applications in tobacco research from 2000 to 2023. By analyzing 749 documents, it identifies research hotspots, key institutions, leading authors, collaboration networks, and high-impact journals. The results show that nanotechnology holds great potential for enhancing tobacco growth, disease prevention, gene expression regulation, and stress resistance. The study also explores potential environmental and health risks of nanoparticles, highlighting the need for scientific research to ensure safe application. Keyword co-occurrence analysis predicts future directions in tobacco research, such as virus-based biomass utilization, green synthesis of nanomaterials, and vaccine development applications. This research provides a scientific foundation for the future development of nanoparticles in tobacco research and valuable references for researchers aiming to innovate nanotechnology applications in agriculture.

Xiaomeng Su, Wanru Zhao, He Dong, Kai Song. Deciphering the Impact of Nanoparticles in Tobacco Research through Scientometric Analysis: A Methodological Perspective. Academic Journal of Agriculture & Life Sciences (2025), Vol. 6, Issue 1: 1-7. https://doi.org/10.25236/AJALS.2025.060101.

[1] Mohanpuria P, Rana NK, Yadav SK: Biosynthesis of nanoparticles: technological concepts and future applications. Journal of nanoparticle research 2008, 10:507-517. 

[2] Rai PK, Kumar V, Lee S, Raza N, Kim K-H, Ok YS, Tsang DC: Nanoparticle-plant interaction: Implications in energy, environment, and agriculture. Environment international 2018, 119:1-19.

[3] Ma Y, Wu Z, Steinmetz NF: In Vitro and Ex Planta Gold-Bonded and Gold-Mineralized Tobacco Mosaic Virus. Langmuir 2023, 39(32):11238-11244.

[4] Nikolova MP, Joshi PB, Chavali MS: Updates on biogenic metallic and metal oxide nanoparticles: therapy, drug delivery and cytotoxicity. Pharmaceutics 2023, 15(6):1650.

[5] Ghosh M, Manivannan J, Sinha S, Chakraborty A, Mallick SK, Bandyopadhyay M, Mukherjee A: In vitro and in vivo genotoxicity of silver nanoparticles. Mutation Research/genetic Toxicology & Environmental Mutagenesis 2012, 749(1-2):60-69.

[6] Al-Askar AA, Aseel DG, El-Gendi H, Sobhy SE, Samy M, Hamdy E, El-Messeiry S, Behiry S, Elbeaino T, Abdelkhalek A: Antiviral Activity of Biosynthesized Silver Nanoparticles from Pomegranate (Punica granatum L.) Peel Extract against Tobacco Mosaic Virus. Plants 2023, 12

[7] Hermes-Lima M, Alencastro ACR, Santos NCF, Navas CA, Beleboni RO: The relevance and recognition of Latin American science. Introduction to the fourth issue of CBP-Latin America. Comparative Biochemistry & Physiology Toxicology & Pharmacology Cbp 2007, 146(1-2):1-9.

[8] Xiangcheng MI, Hou J: Regeneration pattern analysis of Quercus liaotungensis in a temperate forest using two-dimensional wavelet analysis. Academic Abstracts of Chinese Colleges and Universities: Biology 2009, 4(004):491-502.

[9] Dorta-Gonz??Lez P, Dorta-Gonz??Lez MI: Comparing journals from different fields of Science and Social Science through a JCR Subject Categories Normalized Impact Factor. Scientometrics 2013, 95(2):645-672.

[10] Golubic R, Rudes M, Kovacic N, Marusic M, Marusic A: Calculating impact factor: how bibliographical classification of journal items affects the impact factor of large and small journals. science & engineering ethics 2008.

[11] Wilson BDHMA: Tobacco Mosaic Virus: Pioneering Research for a Century || Milestones in the Research on Tobacco Mosaic Virus. Philosophical Transactions Biological Sciences 1999, 354(1383): 521-529.

[12] Husheng J, Wensheng H, Liqiao W, Bingshe X, Xuguang L: The structures and antibacterial properties of nano-SiO2 supported silver/zinc–silver materials. Dental Materials 2008, 24(2):244-249.

[13] Liu Y, Cai H, Wen Y, Song X, Wang X, Zhang Z: Research progress on degradation of biodegradable micro-nano plastics and its toxic effect mechanism on soil ecosystem. Environmental Research 2024, 262.

[14] Mohanpuria P, Rana NK, Yadav SK: Biosynthesis of nanoparticles: technological concepts and future applications. Journal of Nanoparticle Research 2008, 10(3):507-517.

[15] Masara B, van der Poll JA, Maaza M: A nanotechnology-foresight perspective of South Africa. J Nanopart Res 2021, 23(4).

[16] Muhammad ID: A comparative study of research and development related to nanotechnology in Egypt, Nigeria and South Africa. Technology in Society 2022, 68

[17] Wei J, Mu J, Tang Y, Qin D, Duan J, Wu A: Next-generation nanomaterials: advancing ocular anti-inflammatory drug therapy. Journal of Nanobiotechnology 2023, 21(1).

[18] Wu Y, Liu P, Mehrjou B, Chu PK: Interdisciplinary-Inspired Smart Antibacterial Materials and Their Biomedical Applications. Advanced Materials 2023.

[19] Zhang Z, You Y, Ge M, Lin H, Shi J: Functional nanoparticle-enabled non-genetic neuromodulation. Journal of Nanobiotechnology 2023, 21(1).

[20] Shin MD, Shukla S, Chung YH, Beiss V, Chan SK, Ortega-Rivera OA, Wirth DM, Chen A, Sack M, Pokorski JK et al: COVID-19 vaccine development and a potential nanomaterial path forward. Nature Nanotechnology 2020, 15(8):646-655.

[21] Ghosh M, Manivannan J, Sinha S, Chakraborty A, Mallick SK, Bandyopadhyay M, Mukherjee A: In vitro and in vivo genotoxicity of silver nanoparticles. Mutat Res Genet Toxicol Environ Mutagen 2012, 749(1-2):60-69.

[22] Al-Askar AA, Aseel DG, El-Gendi H, Sobhy S, Samy MA, Hamdy E, El-Messeiry S, Behiry SI, Elbeaino T, Abdelkhalek A: Antiviral Activity of Biosynthesized Silver Nanoparticles from Pomegranate (Punica granatum L.) Peel Extract against Tobacco Mosaic Virus. Plants-Basel 2023, 12(11):20.

[23] Ghosh M, Ghosh I, Godderis L, Hoet P, Mukherjee A: Genotoxicity of engineered nanoparticles in higher plants. Mutat Res Genet Toxicol Environ Mutagen 2019, 842:132-145.