This review focuses on the research progress on the correlation between plasma cluster protein levels and cognitive dysfunction in patients with Parkinson's disease. As a molecule with multiple physiological functions, plasma cluster protein has attracted much attention in the study of cognitive dysfunction in Parkinson's disease, and its role in cell protection and protein metabolism may be related to the pathophysiological process of Parkinson's disease on the basis of elaborating the multi-dimensional manifestations of cognitive dysfunction in Parkinson's disease and the multi-faceted characteristics of plasma cluster protein. Some studies have shown abnormal changes in plasma cluster protein levels in patients with severe cognitive dysfunction, but the results vary depending on factors such as samples, detection methods, and disease stages. Plasma cluster proteins may also interact with other biomarkers such as α-synuclein, tau protein, etc., to affect cognitive function. However, current studies are limited by small sample sizes, lack of standardization of detection methods, and unclear mechanisms. This study deeply analyzes the limitations of existing research and prospectively plans multiple paths for future research, aiming to provide comprehensive and in-depth knowledge integration and research orientation for the research field related to cognitive dysfunction in Parkinson's disease.

Ayinishahan Maimat, Ma Jianhua. Research progress on the correlation between plasma cluster protein levels and cognitive dysfunction in patients with Parkinson's disease. Academic Journal of Medicine & Health Sciences (2025), Vol. 6, Issue 1: 57-64. https://doi.org/10.25236/AJMHS.2025.060109.

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