PANoptosis is a form of inflammatory programmed cell death that is regulated by the PANoptosome complex and has key features of pyroptosis, apoptosis, and necroptosis, but cannot be fully characterized by any single pathway of programmed cell death. As an emerging form of cell death, PANoptosis plays a crucial role in the pathological processes of central nervous system diseases such as cerebral ischemia-reperfusion injury, sepsis-associated encephalopathy, Alzheimer's disease, and glioma. This article reviews the discovery, regulation mechanism and research progress of PANoptosis in different central nervous system diseases, aiming to provide reference and theoretical basis for basic research and clinical treatment of central nervous system diseases.

Zhongting Wang, Jiushe Kou. Research Progress of PANoptosis in Central Nervous System Related Diseases. International Journal of Frontiers in Medicine (2025), Vol. 7, Issue 1: 20-25. https://doi.org/10.25236/IJFM.2025.070104.

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