In this study, 100 elderly patients with Parkinson's disease treated in the Department of Neurology of our hospital from December 2022 to December 2024 were selected and divided into study group and control group according to their willingness to treat, with 50 patients in each group. The control group was treated with idebenone, and the study group was treated with hyperbaric oxygen combined with idebenone. The therapeutic effect, inflammatory response, neurological function, cognitive function, and UPDRS scores were compared between the two groups. The total effective rate of the study group was 90. 00%, which was significantly higher than that of the control group (72. 00%) (P < 0.05). Before treatment, the levels of OPN and YKL Y 40 in the two groups were similar (P > 0.05), but decreased after treatment, and the levels in the study group were lower than those in the control group (P < 0.05). Before treatment, the scores of MoCA in the two groups were similar (P > 0.05), and after treatment, the scores of MoCA in the study group were higher than those in the control group (P < 0.05). Before treatment, the UPDRS scores of different grades in the two groups were similar (P > 0.05), but decreased after treatment, and the scores in the study group were lower than those in the control group (P < 0.05). Hyperbaric oxygen combined with idebenone in the treatment of elderly patients with Parkinson's disease has a significant clinical effect, which can improve the inflammatory response and neurological function, and significantly enhance the cognitive ability of patients.

Jiang Dajing, Li Zhilian. Clinical efficacy of hyperbaric oxygen combined with idebenone in the treatment of elderly patients with Parkinson's disease. Academic Journal of Medicine & Health Sciences (2025), Vol. 6, Issue 2: 16-20. https://doi.org/10.25236/AJMHS.2025.060203.

[1] Liu Na, Jiang Sen, Cai Qian, et al.Correlation between serum bone protein and severity of Parkinson's disease and cognitive impairment [J].Journal of Stroke and Neurological Diseases, 2021, 38 (12): 1095-1098. 

[2] Liu Ting, Meng Xinling, Li Dan, et al. Clinical value of osteopontin and TNF ⁃ α in the diagnosis of Alzheimer's disease [J]. Journal of Cardiovascular and Cerebrovascular Diseases of Integrated Traditional Chinese and Western Medicine, 2022, 20 (15): 2853-2857.

[3] Zhang Peng, Wang Zengwu, Zhou Jun, et al.Effects of hyperbaric oxygen on cognitive ability, striatal dopamine and its metabolites in Parkinson's disease model rats [J].Chinese Journal of Nautical Medicine and Hyperbaric Medicine, 2020,27 (6): 696-698,703.

ZHENG Xiuqin, ZHU Tian, CUI Hongxia, et al.Hyperbaric oxygen improves clinical signs and symptoms of Parkinson's disease patients by intervening cell senescence-related phenotype [J].Chinese Journal of Nautical and Hyperbaric Medicine, 2023,30 (2): 176-180.

[5] Chen yuan, Chang Yunyun, Shen Ping, et al. Effect of virtual reality technology combined with exercise rehabilitation nursing on clinical efficacy of hyperbaric oxygen therapy in patients with Parkinson's disease [J]. Chinese Journal of Nautical Medicine and Hyperbaric Medicine, 2023, 30 (3): 332-336.

[6] Zhang Zhanshuai, Qin Shaoqiang, Wang Yaling, et al. Correlation of serum levels of human cartilage glycoprotein 39 and soluble tumor necrosis factor receptor 1 with cardiac function and prognosis in patients with acute myocardial infarction [J]. Chinese Journal of Arteriosclerosis, 2022, 30 (3): 243-247,259.

[7] Parkinson's Disease and Movement Disorder Group of Neurology Branch of Chinese Medical Association, Parkinson's Disease and Movement Disorder Specialty of Neurologist Branch of Chinese Medical Doctor Association. Diagnostic Criteria for Parkinson's Disease in China (2016 Edition) [J]. Chinese Journal of Neurology, 2016, 49 (4): 268-271.

[8] Chinese Medical Association, Journal of Chinese Medical Association, General Practice Branch of Chinese Medical Association, et al. Guidelines for Primary Diagnosis and Treatment of Parkinson's Disease (Practice Edition · 2019) [J]. Chinese Journal of General Practitioners, 2020, 19 (1): 18-26.

[9] Luo Hanjiang, Li Jiayu, Liu Chengwei, et al. Effect of α-Syn overexpression on the expression of dopamine receptor D1 in substantia nigra of Parkinson's disease model mice [J]. Chinese Journal of Neuroimmunology and Neurology, 2021, 28 (1): 36-40.

[10] Xiong Jiangbo, Du Jun, Xiang Bin, et al.Changes of osteopontin, S-100β protein and matrix metalloproteinase-9 levels in patients with acute cerebral hemorrhage and their correlation with neurological function recovery and prognosis [J].Journal of Clinical Practical Hospital, 2021, 18 (5): 60-64.