This paper aims to investigate the mechanism of saponins in the prevention and treatment of liver fibrosis. Based on a comprehensive analysis of relevant literature, the structural characteristics, distribution and main types of saponins were described, and the research progress of saponins in inhibiting lipid peroxidation, reducing hepatic stellate cell activation and proliferation, inhibiting immune inflammatory response, regulating mitochondrial function and other related mechanisms were analyzed in detail. Studies have shown that saponins have multi-target and multi-pathway anti-fibrosis effects, which provides a theoretical basis for their application in the treatment of liver fibrosis.

Lanzhen Xu, Keyu Shao. Role of saponins in the prevention and treatment of liver fibrosis. International Journal of Frontiers in Medicine (2025), Vol. 7, Issue 1: 64-69. https://doi.org/10.25236/IJFM.2025.070110.

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